Prescription medicine
Ritonavir Brand names: Norvir
Ritonavir (Norvir) is a prescription medicine with an FDA approval on record since 1996. FDA's NDC Directory lists it from 7 generic labelers, and pharmacies paid $0.607 per ritonavir 100 mg tablet in the October 7, 2026 NADAC survey.
- Generic listed
- A presentation discontinued
- Boxed warning
Check it at the source: the ritonavir FDA label on DailyMed (effective July 23, 2026, AbbVie Inc.); the NDA 20659 record on Drugs@FDA; every ritonavir label on DailyMed.
Highlights of the record
FDA label of July 23, 2026; NDC Directory, Drugs@FDA and Orange Book, October 8, 2026; NADAC October 7, 2026
Boxed warning
DRUG-DRUG INTERACTIONS LEADING TO POTENTIALLY SERIOUS AND/OR LIFE THREATENING REACTIONS.
Co-administration of NORVIR with several classes of drugs including sedative hypnotics, antiarrhythmics, or ergot alkaloid preparations may result in potentially serious and/or life-threatening adverse events due to possible effects of NORVIR on the hepatic metabolism of certain drugs. Review medications taken by patients prior to prescribing NORVIR or when prescribing other medications to patients already taking NORVIR [see Contraindications ( 4 ), Warnings and Precautions ( 5.1 )]. WARNING: DRUG-DRUG INTERACTIONS LEADING TO POTENTIALLY SERIOUS AND/OR LIFE THREATENING REACTIONS See full prescribing information for complete boxed warning Co-administration of NORVIR with several classes of drugs including sedative hypnotics, antiarrhythmics, or ergot alkaloid preparations may result in potentially serious and/or life-threatening adverse events due to possible effects of NORVIR on the hepatic metabolism of certain drugs. Review medications taken by patients prior to prescribing NORVIR or when prescribing other medications to patients already taking NORVIR.
Used for
From the label: indications and usageNORVIR tablets are indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection.
Forms and strengths
- 100 mg
Film-coated tablet; tablet; powder.
On the market
- Earliest approval on file
- March 1, 1996 Norvir, Abbvie; Drugs@FDA’s file, where older or withdrawn approvals can be missing
- Generic approvals
- 7 first January 15, 2015; 5 with a marketed status in Drugs@FDA
- Labelers listed (NDC)
- 8 of which 7 under generic applications, 1 under brand applications, repackagers included
Supply and safety
- Pharmacy cost (NADAC)
- $0.607 per tablet Ritonavir 100 mg tablet
- Shortage (FDA)
- None current 2 past records
- Recalls by its makers (FDA)
- 1 since 2021 0 Class I among all firms' recalls; latest March 15, 2021
- FAERS reports
- 29,050 through July 30, 2026
What is ritonavir used for?
From the label: indications and usageNORVIR tablets are indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection. NORVIR oral powder is indicated in combination with other antiretroviral agents for the treatment of pediatric patients with HIV-1 infection. NORVIR tablets are HIV protease inhibitors indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection ( 1 ) NORVIR oral powder is indicated in combination with other antiretroviral agents for the treatment of pediatric patients with HIV-1 infection
Conditions named in the indications of ritonavir's FDA labels, with every medicine labeled for each:
FDA pharmacologic class: Cytochrome P450 3A Inhibitor and Protease Inhibitor.
Source: FDA drug label (Norvir), AbbVie Inc., effective July 23, 2026 (SPL set 2849298e-de6e-47bb-8194-56e075b33fc3), via openFDA; the full label on DailyMed
What does the patient leaflet for ritonavir say first?
The FDA-approved Medication Guide or Patient Information that comes with the medicine, in its own words.
From the patient leaflet: What is the most important information I should know about NORVIR?NORVIR can interact with other medicines and cause serious side effects. It is important to know the medicines that should not be taken with NORVIR. See the section “Who should not take NORVIR?”
From the patient leaflet: How should I store NORVIR?NORVIR tablets: Store below 30°C (86°F). You may store NORVIR tablets up to 50°C (122°F) for seven days. Store NORVIR tablets in the original container given to you by the pharmacist. Exposure to high humidity outside the original container for longer than 2 weeks is not recommended. NORVIR oral powder: Store at or below 30°C (86°F). NORVIR oral powder comes in child-resistant packets. Throw away NORVIR that is expired or no longer needed. Keep NORVIR and all medicines out of the reach of children.
Source: FDA drug label (Norvir), AbbVie Inc., effective July 23, 2026 (SPL set 2849298e-de6e-47bb-8194-56e075b33fc3), via openFDA; the full label on DailyMed
Is there a generic for ritonavir (Norvir)?
The FDA approved the first generic ritonavir on January 15, 2015. 7 generic applications are approved; 5 of them carry a current (not discontinued) marketing status in Drugs@FDA; that status is not evidence that the generic is on sale. Drugs@FDA also holds 2 tentative approvals: the FDA found the generic approvable, but patents or exclusivity keep it from final approval for now.
FDA's NDC Directory lists ritonavir from 7 labelers under a generic (ANDA) application and from 1 brand labeler. A listing means the company has registered the product for sale; it does not show that every pharmacy stocks it.
- 1996 earliest approval on file
- 2015 first generic approved
- red ticks recalls
Source: Drugs@FDA, FDA NDC Directory and the Orange Book (openFDA bulk files, October 8, 2026)
What do pharmacies pay for ritonavir (Norvir)?
In CMS's NADAC survey of October 7, 2026, pharmacies paid $0.607 per Ritonavir 100 mg tablet, down 32% from $0.889 on October 8, 2025. The survey records the price, not the reason for a change; large moves often follow a new generic or a list-price change. The chart's scale runs from the lowest to the highest price shown, not from zero. NADAC is what retail pharmacies paid their wholesalers, per unit, in CMS's monthly survey; what a patient pays depends on insurance and the pharmacy.
- Ritonavir 100 mg tablet (generic)
- Norvir 100 mg tablet (brand)
$8.35
$0.607
January 2024October 2026
| Strength and form | Brand or generic | Pharmacy cost | 30 tablets, or one pen or vial | 12-month change |
|---|---|---|---|---|
| Ritonavir 100 mg tablet | Generic | $0.607 per tablet | $18.20 | -32% |
| Norvir 100 mg tablet | Brand | $8.35 per tablet | $250.47 | +0.1% |
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price
Is ritonavir in shortage?
No ritonavir presentation is listed as in shortage in the FDA Drug Shortage Database (read October 8, 2026); its 2 records are all marked to be discontinued, the latest updated July 24, 2026. ASHP keeps a separate shortage list, which can differ.
| Presentation | Company | Status | Updated |
|---|---|---|---|
| Norvir, Oral Powder, 100 mg (NDC 0074-3399-30) | AbbVie Inc. | To Be Discontinued | July 24, 2026 |
| Norvir, Tablet, 100 mg (NDC 0074-2340-30) | AbbVie Inc. | To Be Discontinued | July 24, 2026 |
Source: FDA Drug Shortage Database via openFDA, updated October 8, 2026
Has ritonavir been recalled?
The FDA's Enforcement Report lists 1 recall naming ritonavir since 2021: 0 Class I (the most serious), 1 Class II, 0 Class III; 0 still ongoing. A recall names products and lots, not every product of the medicine.
| Started | Class | Company | Reason |
|---|---|---|---|
| March 15, 2021 | Class II | Cardinal Health Inc. | CGMP Deviations: Intermittent exposure to temperature excursion during storage. |
Source: FDA Enforcement Report (drug recalls) via openFDA, through October 8, 2026
What does the ritonavir label say about other medicines?
The ritonavir label names 112 other medicines in its interaction, contraindication or warning sections. The labels of 27 other medicines name ritonavir. The sentences are the labels' own; a label lists what its studies and reports found, not every interaction.
| Medicine named | Section | What the label says |
|---|---|---|
| Abemaciclib | drug interactions | Concomitant Drug Class/Drug Name: Anticancer Agents: abemaciclib, apalutamide, dasatinib, encorafenib, ibrutinib, ivosidenib, neratinib, nilotinib, venetoclax, vinblastine, vincristine; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ anticancer agents ↓ ritonavir #; … |
| Alfuzosin | contraindications | … [see Drug Interactions ( 7.1 ) and Clinical Pharmacology ( 12.3 )]. ○ Alpha 1- Adrenoreceptor Antagonist: alfuzosin ○ Antianginal: ranolazine ○ Antiarrhythmics: amiodarone, dronedarone, flecainide, propafenone, quinidine ○ Antifungal: voriconazole ○ Anti-gout: colchicine ○ Antipsychotics: lurasidone, pimozide ○ Ergot … |
| Amiodarone | contraindications | … Pharmacology ( 12.3 )]. ○ Alpha 1- Adrenoreceptor Antagonist: alfuzosin ○ Antianginal: ranolazine ○ Antiarrhythmics: amiodarone, dronedarone, flecainide, propafenone, quinidine ○ Antifungal: voriconazole ○ Anti-gout: colchicine ○ Antipsychotics: lurasidone, pimozide ○ Ergot Derivatives: dihydroergotamine, ergotamine … |
| Amitriptyline | drug interactions | Concomitant Drug Class/Drug Name: Antidepressants: nefazodone, selective serotonin reuptake inhibitors (SSRIs): e.g. fluoxetine, paroxetine, tricyclics: e.g. amitriptyline, nortriptyline; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ antidepressants; … |
| Apalutamide | contraindications | … cross-resistance [see Drug Interactions ( 7.2 ) and Clinical Pharmacology ( 12.3 )]. ○ Anticancer Agents: apalutamide ○ Herbal Products: |
| Atazanavir | drug interactions | Concomitant Drug Class/Drug Name: HIV-1 Protease Inhibitor: atazanavir darunavir fosamprenavir; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ amprenavir ↑ atazanavir ↑ darunavir; Clinical Comment: See the complete prescribing information for fosamprenavir, atazanavir, darunavir for details on … |
| Atorvastatin | drug interactions | Concomitant Drug Class/Drug Name: Lipid-modifying agents HMG-CoA Reductase Inhibitor: lovastatin simvastatin atorvastatin rosuvastatin Microsomal triglyceride transfer protein (MTTP) Inhibitor: lomitapide; … |
| Atovaquone | drug interactions | Concomitant Drug Class/Drug Name: Antiparasitic: atovaquone; Effect on Concentration of Ritonavir or Concomitant Drug: ↓ atovaquone; Clinical Comment: Clinical significance is unknown; however, increase in atovaquone dose may be needed. |
| Avanafil | drug interactions | Concomitant Drug Class/Drug Name: PDE5 Inhibitors: avanafil sildenafil, tadalafil, vardenafil; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ avanafil ↑ sildenafil ↑ tadalafil ↑ vardenafil; … |
| Beclomethasone | drug interactions | … can increase the risk for Cushing’s syndrome and adrenal suppression.Alternative corticosteroids including beclomethasone and prednisolone (whose PK and/or PD are less affected by strong CYP3A inhibitors relative to other studied steroids) should be considered, particularly for long-term use. |
| Bedaquiline | drug interactions | Concomitant Drug Class/Drug Name: Antimycobacterial: bedaquiline; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ bedaquiline; Clinical Comment: Bedaquiline should only be used with ritonavir if the benefit of co-administration outweighs the risk. |
| Betamethasone | drug interactions | Concomitant Drug Class/Drug Name: Systemic/Inhaled/ Nasal/Ophthalmic Corticosteroids: e.g., betamethasone budesonide ciclesonide dexamethasone fluticasone methylprednisolone mometasone prednisone triamcinolone; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ glucocorticoids; … |
| Bosentan | drug interactions | Concomitant Drug Class/Drug Name: Endothelin receptor antagonists: bosentan; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ bosentan; Clinical Comment: Co-administration of bosentan in patients on ritonavir: In patients who have been receiving ritonavir for at least 10 days, start bosentan at 62.5 mg once … |
| Budesonide | drug interactions | Concomitant Drug Class/Drug Name: Systemic/Inhaled/ Nasal/Ophthalmic Corticosteroids: e.g., betamethasone budesonide ciclesonide dexamethasone fluticasone methylprednisolone mometasone prednisone triamcinolone; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ glucocorticoids; … |
Every other medicine the ritonavir label names
| Medicine named | Section | What the label says |
|---|---|---|
| Bupropion | drug interactions | Concomitant Drug Class/Drug Name: Antidepressant: bupropion; Effect on Concentration of Ritonavir or Concomitant Drug: ↓ bupropion ↓ active metabolite, hydroxybupropion; … |
| Buspirone | drug interactions | Concomitant Drug Class/Drug Name: Sedative/hypnotics: buspirone, clorazepate, diazepam, estazolam, flurazepam, zolpidem; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ … |
| Carbamazepine | drug interactions | Concomitant Drug Class/Drug Name: Anticonvulsants: carbamazepine, clonazepam, ethosuximide; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ anticonvulsants; … |
| Ciclesonide | drug interactions | Concomitant Drug Class/Drug Name: Systemic/Inhaled/ Nasal/Ophthalmic Corticosteroids: e.g., betamethasone budesonide ciclesonide dexamethasone fluticasone methylprednisolone mometasone prednisone … |
| Clarithromycin | drug interactions | Concomitant Drug Class/Drug Name: Anti-infective: clarithromycin; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ clarithromycin; … |
| Clonazepam | drug interactions | Concomitant Drug Class/Drug Name: Anticonvulsants: carbamazepine, clonazepam, ethosuximide; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ anticonvulsants; … |
| Clorazepate | drug interactions | Concomitant Drug Class/Drug Name: Sedative/hypnotics: buspirone, clorazepate, diazepam, estazolam, flurazepam, zolpidem; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ … |
| Colchicine | contraindications | … flecainide, propafenone, quinidine ○ Antifungal: voriconazole ○ Anti-gout: colchicine ○ Antipsychotics: lurasidone, pimozide ○ Ergot Derivatives: dihydroergotamine, ergotamine, methylergonovine ○ GI … |
| Cyclosporine | drug interactions | Concomitant Drug Class/Drug Name: Immunosuppressants: cyclosporine, tacrolimus, sirolimus (rapamycin); Effect on Concentration of Ritonavir or Concomitant Drug: ↑ immunosuppressants; … |
| Darunavir | drug interactions | Concomitant Drug Class/Drug Name: HIV-1 Protease Inhibitor: atazanavir darunavir fosamprenavir; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ amprenavir ↑ atazanavir ↑ darunavir; … |
| Dasatinib | drug interactions | Concomitant Drug Class/Drug Name: Anticancer Agents: abemaciclib, apalutamide, dasatinib, encorafenib, ibrutinib, ivosidenib, neratinib, nilotinib, venetoclax, vinblastine, vincristine; … |
| Desipramine | drug interactions | Concomitant Drug Class/Drug Name: Antidepressant: desipramine; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ desipramine; … |
| Dexamethasone | drug interactions | Concomitant Drug Class/Drug Name: Systemic/Inhaled/ Nasal/Ophthalmic Corticosteroids: e.g., betamethasone budesonide ciclesonide dexamethasone fluticasone methylprednisolone mometasone prednisone … |
| Diazepam | drug interactions | Concomitant Drug Class/Drug Name: Sedative/hypnotics: buspirone, clorazepate, diazepam, estazolam, flurazepam, zolpidem; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ … |
| Digoxin | drug interactions | Concomitant Drug Class/Drug Name: Digoxin; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ digoxin; Clinical Comment: Concomitant administration of ritonavir with digoxin may increase … |
| Dihydroergotamine | contraindications | … colchicine ○ Antipsychotics: lurasidone, pimozide ○ Ergot Derivatives: dihydroergotamine, ergotamine, methylergonovine ○ GI Motility Agent: cisapride ○ HMG-CoA Reductase Inhibitors: lovastatin … |
| Diltiazem | drug interactions | Concomitant Drug Class/Drug Name: Calcium channel blockers: diltiazem, nifedipine, verapamil; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ calcium channel blockers; … |
| Disopyramide | drug interactions | Concomitant Drug Class/Drug Name: Antiarrhythmics: disopyramide, lidocaine, mexiletine; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ antiarrhythmics; … |
| Divalproex | drug interactions | Concomitant Drug Class/Drug Name: Anticonvulsants: divalproex, lamotrigine, phenytoin; Effect on Concentration of Ritonavir or Concomitant Drug: ↓ anticonvulsants; … |
| Dronabinol | drug interactions | Concomitant Drug Class/Drug Name: Antiemetic: dronabinol; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ dronabinol; … |
| Dronedarone | contraindications | … alfuzosin ○ Antianginal: ranolazine ○ Antiarrhythmics: amiodarone, dronedarone, flecainide, propafenone, quinidine ○ Antifungal: voriconazole ○ Anti-gout: colchicine ○ Antipsychotics: lurasidone … |
| Elagolix | drug interactions | Concomitant Drug Class/Drug Name: GnRH Receptor Antagonists: elagolix; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ elagolix ↓ ritonavir; … |
| Encorafenib | drug interactions | Concomitant Drug Class/Drug Name: Anticancer Agents: abemaciclib, apalutamide, dasatinib, encorafenib, ibrutinib, ivosidenib, neratinib, nilotinib, venetoclax, vinblastine, vincristine; … |
| Ergotamine | contraindications | … ○ Antipsychotics: lurasidone, pimozide ○ Ergot Derivatives: dihydroergotamine, ergotamine, methylergonovine ○ GI Motility Agent: cisapride ○ HMG-CoA Reductase Inhibitors: lovastatin, simvastatin ○ … |
| Estazolam | drug interactions | Concomitant Drug Class/Drug Name: Sedative/hypnotics: buspirone, clorazepate, diazepam, estazolam, flurazepam, zolpidem; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ … |
| Ethosuximide | drug interactions | Concomitant Drug Class/Drug Name: Anticonvulsants: carbamazepine, clonazepam, ethosuximide; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ anticonvulsants; … |
| Fentanyl | drug interactions | Concomitant Drug Class/Drug Name: Analgesics, Opioid: tramadol, propoxyphene, methadone, fentanyl; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ analgesics ↓ methadone ↑ fentanyl; … |
| Flecainide | contraindications | … Antianginal: ranolazine ○ Antiarrhythmics: amiodarone, dronedarone, flecainide, propafenone, quinidine ○ Antifungal: voriconazole ○ Anti-gout: colchicine ○ Antipsychotics: lurasidone, pimozide ○ … |
| Fluoxetine | drug interactions | Concomitant Drug Class/Drug Name: Antidepressants: nefazodone, selective serotonin reuptake inhibitors (SSRIs): e.g. fluoxetine, paroxetine, tricyclics: e.g. amitriptyline, nortriptyline; … |
| Flurazepam | drug interactions | Concomitant Drug Class/Drug Name: Sedative/hypnotics: buspirone, clorazepate, diazepam, estazolam, flurazepam, zolpidem; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ … |
| Fluticasone | drug interactions | Concomitant Drug Class/Drug Name: Systemic/Inhaled/ Nasal/Ophthalmic Corticosteroids: e.g., betamethasone budesonide ciclesonide dexamethasone fluticasone methylprednisolone mometasone prednisone … |
| Fosamprenavir | drug interactions | Concomitant Drug Class/Drug Name: HIV-1 Protease Inhibitor: atazanavir darunavir fosamprenavir; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ amprenavir ↑ atazanavir ↑ darunavir; … |
| Fostamatinib | drug interactions | Concomitant Drug Class/Drug Name: Kinase Inhibitors: fostamatinib (also see anticancer agents above); Effect on Concentration of Ritonavir or Concomitant Drug: ↑ fostamatinib metabolite R406; … |
| Glecaprevir and pibrentasvir | drug interactions | Hepatitis C direct acting antiviral: glecaprevir/pibrentasvir simeprevir ↑ glecaprevir ↑ pibrentasvir ↑simeprevir It is not recommended to co-administer ritonavir with glecaprevir/pibrentasvir, or … |
| Ibrutinib | drug interactions | Concomitant Drug Class/Drug Name: Anticancer Agents: abemaciclib, apalutamide, dasatinib, encorafenib, ibrutinib, ivosidenib, neratinib, nilotinib, venetoclax, vinblastine, vincristine; … |
| Itraconazole | drug interactions | Concomitant Drug Class/Drug Name: Antifungals: ketoconazole itraconazole voriconazole; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ ketoconazole ↑ itraconazole ↓ voriconazole; … |
| Ivosidenib | drug interactions | Concomitant Drug Class/Drug Name: Anticancer Agents: abemaciclib, apalutamide, dasatinib, encorafenib, ibrutinib, ivosidenib, neratinib, nilotinib, venetoclax, vinblastine, vincristine; … |
| Ketoconazole | drug interactions | Concomitant Drug Class/Drug Name: Antifungals: ketoconazole itraconazole voriconazole; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ ketoconazole ↑ itraconazole ↓ voriconazole; … |
| Lamotrigine | drug interactions | Concomitant Drug Class/Drug Name: Anticonvulsants: divalproex, lamotrigine, phenytoin; Effect on Concentration of Ritonavir or Concomitant Drug: ↓ anticonvulsants; … |
| Lidocaine | drug interactions | Concomitant Drug Class/Drug Name: Antiarrhythmics: disopyramide, lidocaine, mexiletine; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ antiarrhythmics; … |
| Lomitapide | contraindications | … simvastatin ○ Microsomal triglyceride transfer protein (MTTP) Inhibitor: lomitapide ○ Non-opioid Analgesic (selective blocker of Na v 1.8 sodium channels): suzetrigine ○ PDE5 Inhibitor: sildenafil … |
| Lovastatin | contraindications | … methylergonovine ○ GI Motility Agent: cisapride ○ HMG-CoA Reductase Inhibitors: lovastatin, simvastatin ○ Microsomal triglyceride transfer protein (MTTP) Inhibitor: lomitapide ○ Non-opioid Analgesic … |
| Lurasidone | contraindications | … Antifungal: voriconazole ○ Anti-gout: colchicine ○ Antipsychotics: lurasidone, pimozide ○ Ergot Derivatives: dihydroergotamine, ergotamine, methylergonovine ○ GI Motility Agent: cisapride ○ HMG-CoA … |
| Maraviroc | drug interactions | Concomitant Drug Class/Drug Name: HIV-1 CCR5 – antagonist: maraviroc; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ maraviroc; … |
| Meperidine | drug interactions | Concomitant Drug Class/Drug Name: Anesthetic: meperidine; Effect on Concentration of Ritonavir or Concomitant Drug: ↓ meperidine/ ↑ normeperidine (metabolite); … |
| Methadone | drug interactions | Concomitant Drug Class/Drug Name: Analgesics, Opioid: tramadol, propoxyphene, methadone, fentanyl; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ analgesics ↓ methadone ↑ fentanyl; … |
| Methamphetamine | drug interactions | A dose decrease of methamphetamine may be needed when co-administered with ritonavir. |
| Methylergonovine | contraindications | … lurasidone, pimozide ○ Ergot Derivatives: dihydroergotamine, ergotamine, methylergonovine ○ GI Motility Agent: cisapride ○ HMG-CoA Reductase Inhibitors: lovastatin, simvastatin ○ Microsomal … |
| Methylprednisolone | drug interactions | … e.g., betamethasone budesonide ciclesonide dexamethasone fluticasone methylprednisolone mometasone prednisone triamcinolone; … |
| Metoprolol | drug interactions | Concomitant Drug Class/Drug Name: β-Blockers: metoprolol, timolol; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ beta-blockers; … |
| Mexiletine | drug interactions | Concomitant Drug Class/Drug Name: Antiarrhythmics: disopyramide, lidocaine, mexiletine; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ antiarrhythmics; … |
| Midazolam | contraindications | … hypertension ○ Sedative/Hypnotics: triazolam, orally administered midazolam |
| Mometasone | drug interactions | … budesonide ciclesonide dexamethasone fluticasone methylprednisolone mometasone prednisone triamcinolone; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ glucocorticoids; … |
| Nefazodone | drug interactions | Concomitant Drug Class/Drug Name: Antidepressants: nefazodone, selective serotonin reuptake inhibitors (SSRIs): e.g. fluoxetine, paroxetine, tricyclics: e.g. amitriptyline, nortriptyline; … |
| Neratinib | drug interactions | Concomitant Drug Class/Drug Name: Anticancer Agents: abemaciclib, apalutamide, dasatinib, encorafenib, ibrutinib, ivosidenib, neratinib, nilotinib, venetoclax, vinblastine, vincristine; … |
| Nifedipine | drug interactions | Concomitant Drug Class/Drug Name: Calcium channel blockers: diltiazem, nifedipine, verapamil; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ calcium channel blockers; … |
| Nilotinib | drug interactions | Concomitant Drug Class/Drug Name: Anticancer Agents: abemaciclib, apalutamide, dasatinib, encorafenib, ibrutinib, ivosidenib, neratinib, nilotinib, venetoclax, vinblastine, vincristine; … |
| Nortriptyline | drug interactions | … (SSRIs): e.g. fluoxetine, paroxetine, tricyclics: e.g. amitriptyline, nortriptyline; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ antidepressants; … |
| Paroxetine | drug interactions | Concomitant Drug Class/Drug Name: Antidepressants: nefazodone, selective serotonin reuptake inhibitors (SSRIs): e.g. fluoxetine, paroxetine, tricyclics: e.g. amitriptyline, nortriptyline; … |
| Perphenazine | drug interactions | Concomitant Drug Class/Drug Name: Antipsychotics: perphenazine, risperidone, thioridazine; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ antipsychotics; … |
| Phenytoin | drug interactions | Concomitant Drug Class/Drug Name: Anticonvulsants: divalproex, lamotrigine, phenytoin; Effect on Concentration of Ritonavir or Concomitant Drug: ↓ anticonvulsants; … |
| Pimozide | contraindications | … voriconazole ○ Anti-gout: colchicine ○ Antipsychotics: lurasidone, pimozide ○ Ergot Derivatives: dihydroergotamine, ergotamine, methylergonovine ○ GI Motility Agent: cisapride ○ HMG-CoA Reductase … |
| Prednisolone | drug interactions | … betamethasone budesonide ciclesonide dexamethasone fluticasone methylprednisolone mometasone prednisone triamcinolone; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ glucocorticoids; … |
| Prednisone | drug interactions | … ciclesonide dexamethasone fluticasone methylprednisolone mometasone prednisone triamcinolone; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ glucocorticoids; … |
| Propafenone | contraindications | … ranolazine ○ Antiarrhythmics: amiodarone, dronedarone, flecainide, propafenone, quinidine ○ Antifungal: voriconazole ○ Anti-gout: colchicine ○ Antipsychotics: lurasidone, pimozide ○ Ergot … |
| Quetiapine | drug interactions | Consider alternative antiretroviral therapy to avoid increases in quetiapine exposures. |
| Quinidine | contraindications | … Antiarrhythmics: amiodarone, dronedarone, flecainide, propafenone, quinidine ○ Antifungal: voriconazole ○ Anti-gout: colchicine ○ Antipsychotics: lurasidone, pimozide ○ Ergot Derivatives … |
| Quinine | drug interactions | Concomitant Drug Class/Drug Name: Antiparasitic: quinine; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ quinine; … |
| Raltegravir | drug interactions | Concomitant Drug Class/Drug Name: Integrase Inhibitor: raltegravir; Effect on Concentration of Ritonavir or Concomitant Drug: ↓ raltegravir; … |
| Ranolazine | contraindications | … )]. ○ Alpha 1- Adrenoreceptor Antagonist: alfuzosin ○ Antianginal: ranolazine ○ Antiarrhythmics: amiodarone, dronedarone, flecainide, propafenone, quinidine ○ Antifungal: voriconazole ○ Anti-gout … |
| Rifabutin | drug interactions | Concomitant Drug Class/Drug Name: Antimycobacterial: rifabutin; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ rifabutin and rifabutin metabolite; … |
| Rifampin | drug interactions | … saquinavir and ritonavir. Saquinavir/ritonavir in combination with rifampin is not recommended due to the risk of severe hepatotoxicity (presenting as increased hepatic transaminases) if the three … |
| Risperidone | drug interactions | Concomitant Drug Class/Drug Name: Antipsychotics: perphenazine, risperidone, thioridazine; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ antipsychotics; … |
| Rivaroxaban | drug interactions | Concomitant Drug Class/Drug Name: Anticoagulant: rivaroxaban; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ rivaroxaban; … |
| Rosuvastatin | drug interactions | Concomitant Drug Class/Drug Name: Lipid-modifying agents HMG-CoA Reductase Inhibitor: lovastatin simvastatin atorvastatin rosuvastatin Microsomal triglyceride transfer protein (MTTP) Inhibitor … |
| Salmeterol | drug interactions | Concomitant Drug Class/Drug Name: Long-acting beta-adrenoceptor agonist: salmeterol; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ salmeterol; … |
| Sildenafil | contraindications | … blocker of Na v 1.8 sodium channels): suzetrigine ○ PDE5 Inhibitor: sildenafil (Revatio ® ) when used for the treatment of pulmonary arterial hypertension ○ Sedative/Hypnotics: triazolam, orally … |
| Simvastatin | contraindications | … Motility Agent: cisapride ○ HMG-CoA Reductase Inhibitors: lovastatin, simvastatin ○ Microsomal triglyceride transfer protein (MTTP) Inhibitor: lomitapide ○ Non-opioid Analgesic (selective blocker of … |
| Sirolimus | drug interactions | Concomitant Drug Class/Drug Name: Immunosuppressants: cyclosporine, tacrolimus, sirolimus (rapamycin); Effect on Concentration of Ritonavir or Concomitant Drug: ↑ immunosuppressants; … |
| Suzetrigine | contraindications | … Non-opioid Analgesic (selective blocker of Na v 1.8 sodium channels): suzetrigine ○ PDE5 Inhibitor: sildenafil (Revatio ® ) when used for the treatment of pulmonary arterial hypertension ○ … |
| Tacrolimus | drug interactions | Concomitant Drug Class/Drug Name: Immunosuppressants: cyclosporine, tacrolimus, sirolimus (rapamycin); Effect on Concentration of Ritonavir or Concomitant Drug: ↑ immunosuppressants; … |
| Tadalafil | drug interactions | Concomitant Drug Class/Drug Name: PDE5 Inhibitors: avanafil sildenafil, tadalafil, vardenafil; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ avanafil ↑ sildenafil ↑ tadalafil ↑ … |
| Theophylline | drug interactions | Concomitant Drug Class/Drug Name: Bronchodilator: theophylline; Effect on Concentration of Ritonavir or Concomitant Drug: ↓ theophylline; … |
| Thioridazine | drug interactions | Concomitant Drug Class/Drug Name: Antipsychotics: perphenazine, risperidone, thioridazine; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ antipsychotics; … |
| Timolol | drug interactions | Concomitant Drug Class/Drug Name: β-Blockers: metoprolol, timolol; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ beta-blockers; … |
| Tramadol | drug interactions | Concomitant Drug Class/Drug Name: Analgesics, Opioid: tramadol, propoxyphene, methadone, fentanyl; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ analgesics ↓ methadone ↑ fentanyl; … |
| Trazodone | drug interactions | Concomitant Drug Class/Drug Name: Antidepressant: trazodone; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ trazodone; … |
| Triamcinolone | drug interactions | … dexamethasone fluticasone methylprednisolone mometasone prednisone triamcinolone; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ glucocorticoids; … |
| Triazolam | contraindications | … treatment of pulmonary arterial hypertension ○ Sedative/Hypnotics: triazolam, orally administered midazolam |
| Valproic acid | drug interactions | Anticonvulsants: divalproex, lamotrigine, phenytoin ↓ anticonvulsants A dose increase may be needed for these drugs when co-administered with ritonavir and therapeutic concentration monitoring is … |
| Vardenafil | drug interactions | Concomitant Drug Class/Drug Name: PDE5 Inhibitors: avanafil sildenafil, tadalafil, vardenafil; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ avanafil ↑ sildenafil ↑ tadalafil ↑ … |
| Venetoclax | drug interactions | Concomitant Drug Class/Drug Name: Anticancer Agents: abemaciclib, apalutamide, dasatinib, encorafenib, ibrutinib, ivosidenib, neratinib, nilotinib, venetoclax, vinblastine, vincristine; … |
| Verapamil | drug interactions | Concomitant Drug Class/Drug Name: Calcium channel blockers: diltiazem, nifedipine, verapamil; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ calcium channel blockers; … |
| Vinblastine | drug interactions | … encorafenib, ibrutinib, ivosidenib, neratinib, nilotinib, venetoclax, vinblastine, vincristine; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ anticancer agents ↓ ritonavir #; … |
| Vincristine | drug interactions | … ibrutinib, ivosidenib, neratinib, nilotinib, venetoclax, vinblastine, vincristine; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ anticancer agents ↓ ritonavir #; … |
| Voriconazole | contraindications | … amiodarone, dronedarone, flecainide, propafenone, quinidine ○ Antifungal: voriconazole ○ Anti-gout: colchicine ○ Antipsychotics: lurasidone, pimozide ○ Ergot Derivatives: dihydroergotamine … |
| Warfarin | drug interactions | Concomitant Drug Class/Drug Name: Anticoagulant: warfarin; Effect on Concentration of Ritonavir or Concomitant Drug: ↑↓ warfarin; … |
| Zolpidem | drug interactions | Concomitant Drug Class/Drug Name: Sedative/hypnotics: buspirone, clorazepate, diazepam, estazolam, flurazepam, zolpidem; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ … |
Other labels that name ritonavir
- Acetaminophen and benzhydrocodone
- Afatinib
- Alprazolam
- Amlodipine and telmisartan
- Apixaban
- Buprenorphine
- Cabazitaxel
- Cabozantinib
- Calcifediol
- Canagliflozin
- Cladribine
- Cobicistat
- Codeine
- Darifenacin
- Deferasirox
- Desogestrel and ethinyl estradiol
- Docetaxel
- Dolutegravir
- Doxazosin
- Drospirenone and estetrol
- Drospirenone and ethinyl estradiol
- Drospirenone and ethinyl estradiol and levomefolate
- Dutasteride
- Efavirenz
- Eluxadoline
- Emtricitabine and tenofovir alafenamide
- Erlotinib
- Esomeprazole
- Estradiol
- Estrogens conjugated
- Ethinyl estradiol and ethynodiol
- Ethinyl estradiol and ferrous bisglycinate and levonorgestrel
- Ethinyl estradiol and ferrous fumarate and levonorgestrel
- Ethinyl estradiol and levonorgestrel
- Ethinyl estradiol and norelgestromin
- Ethinyl estradiol and norgestimate
- Ethinyl estradiol and norgestrel
- Ethinyl estradiol and segesterone
- Etonogestrel
- Etravirine
- Everolimus
- Hydrocodone
- Hydrocortisone
- Irinotecan
- Isavuconazonium
- Lenacapavir
- Levocetirizine
- Loperamide
- Macitentan
- Mifepristone
- Naldemedine
- Nelfinavir
- Nevirapine
- Nimodipine
- Norethindrone
- Orforglipron
- Oxycodone
- Paclitaxel
- Palbociclib
- Paricalcitol
- Posaconazole
- Praziquantel
- Propranolol
- Riociguat
- Saxagliptin
- Silodosin
- Sofosbuvir
- Sufentanil
- Suvorexant
- Temsirolimus
- Thiotepa
- Ticagrelor
- Tolvaptan
- Toremifene
- Trabectedin
- Trastuzumab emtansine
- Umeclidinium and vilanterol
Source: FDA drug label (Norvir), AbbVie Inc., effective July 23, 2026 (SPL set 2849298e-de6e-47bb-8194-56e075b33fc3), via openFDA; the full label on DailyMed
What do FAERS reports show for ritonavir?
The FDA Adverse Event Reporting System holds 29,050 reports that list ritonavir among the medicines taken, through July 30, 2026, each a report of something that happened, not proof the medicine caused it; 2,638 are coded as a death and 9,659 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.
Reports received each year
The most reported reactions
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026
What else is labeled for the same conditions as ritonavir?
43 other medicines are given the same way (oral) and in the same FDA class as ritonavir or labeled mainly for the same use (HIV), the same class first. HIV lists all 47 medicines labeled for it, by any route. The first 8 are below. They are listed as records, not as substitutes: whether one can replace another is a prescriber's decision.
| Medicine | Shared indication | Generic labelers (oral) | Pharmacy cost | Shortage |
|---|---|---|---|---|
| Darunavir | HIV | 13 labelers | $1.16 per tablet 600 mg tablet | No current entry |
| Atazanavir | HIV | 4 labelers | $2.23 per capsule 300 mg capsule | No current entry |
| Cobicistat and darunavir | HIV | none listed | $79.99 per tablet 800 mg-150 mg tablet | No current entry |
| Fosamprenavir | HIV | 2 labelers | n/a | No current entry |
| Nelfinavir | HIV | none listed | n/a | No current entry |
| Atazanavir and cobicistat | HIV | none listed | $52.05 per tablet 300 mg-150 mg tablet | A presentation being discontinued |
| Cobicistat | HIV | none listed | n/a | A presentation being discontinued |
| Cobicistat, darunavir, emtricitabine and tenofovir alafenamide | HIV | none listed | $152.87 per tablet 800-150-200-10 mg tablet | No current entry |
Source: FDA drug labels (indications), NDC Directory, NADAC of October 7, 2026, FDA shortages (October 8, 2026)
What next?
- Alternatives to ritonavir
- 43 medicines for the same use
- Other cytochrome p450 3a inhibitors
- the pharmacologic class, with prices and generics
- Ritonavir side effects
- the label's list beside FAERS reports
- Ritonavir shortage record
- every presentation, company and date
- Check an interaction
- what two or more labels say about each other