What the FDA labels say about taking them together
Raltegravir and ritonavir
Raltegravir's FDA label of October 18, 2024 names ritonavir in its drug interactions section, and ritonavir's label names raltegravir too. The ritonavir label: “The effects of ritonavir on raltegravir with ritonavir dosage regimens greater than 100 mg twice daily have not been evaluated, however raltegravir concentrations may be decreased with ritonavir coadministration.”
Check it at the source: the raltegravir FDA label on DailyMed (effective October 18, 2024, Merck Sharp & Dohme LLC); the ritonavir FDA label on DailyMed (effective July 23, 2026, AbbVie Inc.).
What does the raltegravir label say about ritonavir?
Raltegravir label, drug interactionsConcomitant Drug Class/Drug Name: Tipranavir/ritonavir; Effect on Concentration of Raltegravir: No dose adjustment; Clinical Comment for ISENTRESS: Coadministration is not recommended
Source: FDA drug label (ISENTRESS), Merck Sharp & Dohme LLC, effective October 18, 2024 (SPL set 89a5ec53-d956-4329-8004-0f40f51c88a3), via openFDA; the full label on DailyMed
What does the ritonavir label say about raltegravir?
Ritonavir label, drug interactionsConcomitant Drug Class/Drug Name: Integrase Inhibitor: raltegravir; Effect on Concentration of Ritonavir or Concomitant Drug: ↓ raltegravir; Clinical Comment: The effects of ritonavir on raltegravir with ritonavir dosage regimens greater than 100 mg twice daily have not been evaluated, however raltegravir concentrations may be decreased with ritonavir coadministration.
Source: FDA drug label (Norvir), AbbVie Inc., effective July 23, 2026 (SPL set 2849298e-de6e-47bb-8194-56e075b33fc3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Raltegravir | Ritonavir | |
|---|---|---|
| Labeled for | HIV | HIV |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $34.54 per tablet 400 mg tablet | $0.607 per tablet 100 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once