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What the FDA labels say about taking them together

Ritonavir and theophylline

Ritonavir's FDA label of July 23, 2026 names theophylline in its drug interactions section; the theophylline label PlainMeds reads does not name ritonavir. The ritonavir label: “Increased dosage of theophylline may be required; therapeutic monitoring should be considered.”

Check it at the source: the ritonavir FDA label on DailyMed (effective July 23, 2026, AbbVie Inc.); the theophylline FDA label on DailyMed (effective March 10, 2026, Strides Pharma Science Limited).

What does the ritonavir label say about theophylline?

Ritonavir label, drug interactions

Concomitant Drug Class/Drug Name: Bronchodilator: theophylline; Effect on Concentration of Ritonavir or Concomitant Drug: ↓ theophylline; Clinical Comment: Increased dosage of theophylline may be required; therapeutic monitoring should be considered.

Source: FDA drug label (Norvir), AbbVie Inc., effective July 23, 2026 (SPL set 2849298e-de6e-47bb-8194-56e075b33fc3), via openFDA; the full label on DailyMed

What does the theophylline label say about ritonavir?

Theophylline's label (effective March 10, 2026) does not name ritonavir in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Theophylline), Strides Pharma Science Limited, effective March 10, 2026 (SPL set b7a90ccf-9c32-40cc-9008-7e55b3da4dfd), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

7Ritonavir generic labelers
26Theophylline generic labelers
RitonavirTheophylline
Labeled forHIVAsthma
Boxed warningYesNo
Pharmacy cost (NADAC)$0.607 per tablet 100 mg tablet$0.330 per tablet 300 mg tablet
Shortage nowA presentation being discontinuedNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?