What the FDA labels say about taking them together
Midazolam and ritonavir
Ritonavir's FDA label of July 23, 2026 names midazolam in its contraindications section; the midazolam labels PlainMeds reads (4) do not name ritonavir. The ritonavir label: “Contraindicated due to potential for prolonged or increased sedation or respiratory depression.”
Check it at the source: the midazolam FDA label on DailyMed (effective January 1, 2024, Fresenius Kabi USA, LLC); the ritonavir FDA label on DailyMed (effective July 23, 2026, AbbVie Inc.).
What does the midazolam label say about ritonavir?
Midazolam's label (effective January 1, 2024) and its 3 other brand-application labels do not name ritonavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Midazolam), Fresenius Kabi USA, LLC, effective January 1, 2024 (SPL set 1cc9ba6e-fa1b-405e-9de8-720c567b2a73), via openFDA; the full label on DailyMed
What does the ritonavir label say about midazolam?
Ritonavir label, contraindications… Non-opioid Analgesic (selective blocker of Na v 1.8 sodium channels): suzetrigine ○ PDE5 Inhibitor: sildenafil (Revatio ® ) when used for the treatment of pulmonary arterial hypertension ○ Sedative/Hypnotics: triazolam, orally administered midazolam
Ritonavir label, drug interactionsConcomitant Drug Class/Drug Name: Sedative/Hypnotics: triazolam, orally administered midazolam; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ triazolam ↑ midazolam; Clinical Comment: Contraindicated due to potential for prolonged or increased sedation or respiratory depression [see Contraindications () ].
Source: FDA drug label (Norvir), AbbVie Inc., effective July 23, 2026 (SPL set 2849298e-de6e-47bb-8194-56e075b33fc3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Midazolam | Ritonavir | |
|---|---|---|
| Labeled for | n/a | HIV |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.233 per mL 2 mg/2 mL vial | $0.607 per tablet 100 mg tablet |
| Shortage now | In shortage | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once