What the FDA labels say about taking them together
Ritonavir and suvorexant
Suvorexant's FDA label of March 10, 2025 names ritonavir in its drug interactions section; the ritonavir label PlainMeds reads does not name suvorexant. The suvorexant label: “CYP3A Inhibitors Concomitant use of BELSOMRA with strong inhibitors of CYP3A is not recommended.”
Check it at the source: the ritonavir FDA label on DailyMed (effective July 23, 2026, AbbVie Inc.); the suvorexant FDA label on DailyMed (effective March 10, 2025, Merck Sharp & Dohme LLC).
What does the ritonavir label say about suvorexant?
Ritonavir's label (effective July 23, 2026) does not name suvorexant in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Norvir), AbbVie Inc., effective July 23, 2026 (SPL set 2849298e-de6e-47bb-8194-56e075b33fc3), via openFDA; the full label on DailyMed
What does the suvorexant label say about ritonavir?
Suvorexant label, drug interactionsCYP3A Inhibitors Concomitant use of BELSOMRA with strong inhibitors of CYP3A (e.g., ketoconazole, itraconazole, posaconazole, clarithromycin, nefazodone, ritonavir, saquinavir, nelfinavir, indinavir, boceprevir, telaprevir, telithromycin and conivaptan) is not recommended [see Clinical Pharmacology (12.3) ].
Source: FDA drug label (BELSOMRA), Merck Sharp & Dohme LLC, effective March 10, 2025 (SPL set e5b72731-1acb-45b7-9c13-290ad12d3951), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ritonavir | Suvorexant | |
|---|---|---|
| Labeled for | HIV | Insomnia |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.607 per tablet 100 mg tablet | $15.21 per tablet 10 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once