What the FDA labels say about taking them together
Propranolol and ritonavir
Propranolol's FDA label of January 15, 2026 names ritonavir in its drug interactions section; ritonavir's label does not name propranolol itself but warns about its class (Beta blockers). The propranolol label: “… amiodarone, cimetidine, delavudin, fluoxetine, paroxetine, quinidine, and ritonavir.”
Check it at the source: the propranolol FDA label on DailyMed (effective January 15, 2026, Mylan Pharmaceuticals Inc.); the ritonavir FDA label on DailyMed (effective July 23, 2026, AbbVie Inc.).
What does the propranolol label say about ritonavir?
Propranolol label, drug interactionsSubstrates or Inhibitors of CYP2D6 Blood levels and/or toxicity of propranolol may be increased by co-administration with substrates or inhibitors of CYP2D6, such as amiodarone, cimetidine, delavudin, fluoxetine, paroxetine, quinidine, and ritonavir.
Source: FDA drug label (Propranolol Hydrochloride), Mylan Pharmaceuticals Inc., effective January 15, 2026 (SPL set b94dcec7-7633-4a33-9cea-48161adeaf93), via openFDA; the full label on DailyMed
What does the ritonavir label say about propranolol?
Ritonavir's label does not name propranolol itself; it warns about its class (Beta blockers):
Ritonavir label, drug interactionsRefer to the quetiapine prescribing information for initial dosing and titration of quetiapine. β-Blockers: metoprolol, timolol ↑ beta-blockers Caution is warranted and clinical monitoring of patients is recommended.
Ritonavir label, warnings and precautionsThe impact on the PR interval of co-administration of ritonavir with other drugs that prolong the PR interval (including calcium channel blockers, beta-adrenergic blockers, digoxin and atazanavir) has not been evaluated.
Source: FDA drug label (Norvir), AbbVie Inc., effective July 23, 2026 (SPL set 2849298e-de6e-47bb-8194-56e075b33fc3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Propranolol | Ritonavir | |
|---|---|---|
| Labeled for | High blood pressure, Angina, Atrial fibrillation, Migraine | HIV |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0493 per tablet 20 mg tablet | $0.607 per tablet 100 mg tablet |
| Shortage now | In shortage | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once