What the FDA labels say about taking them together
Ritonavir and sirolimus
Ritonavir's FDA label of July 23, 2026 names sirolimus in its drug interactions section, and sirolimus's label names ritonavir too. The ritonavir label: “Therapeutic concentration monitoring is recommended for immunosuppressant agents when co-administered with ritonavir.”
Check it at the source: the ritonavir FDA label on DailyMed (effective July 23, 2026, AbbVie Inc.); the sirolimus FDA label on DailyMed (effective January 28, 2026, Glenmark Pharmaceuticals Inc., USA).
What does the ritonavir label say about sirolimus?
Ritonavir label, drug interactionsConcomitant Drug Class/Drug Name: Immunosuppressants: cyclosporine, tacrolimus, sirolimus (rapamycin); Effect on Concentration of Ritonavir or Concomitant Drug: ↑ immunosuppressants; Clinical Comment: Therapeutic concentration monitoring is recommended for immunosuppressant agents when co-administered with ritonavir.
Source: FDA drug label (Norvir), AbbVie Inc., effective July 23, 2026 (SPL set 2849298e-de6e-47bb-8194-56e075b33fc3), via openFDA; the full label on DailyMed
What does the sirolimus label say about ritonavir?
Sirolimus label, drug interactionsDrugs that could increase sirolimus blood concentrations: Bromocriptine, cimetidine, cisapride, clotrimazole, danazol, diltiazem, fluconazole, letermovir, protease inhibitors (e.g., HIV and hepatitis C that include drugs such as ritonavir, indinavir, boceprevir, and telaprevir), metoclopramide, nicardipine, troleandomycin, verapamil
Source: FDA drug label (sirolimus), Glenmark Pharmaceuticals Inc., USA, effective January 28, 2026 (SPL set 57fb4d90-3ccb-4a69-af1e-53be83f7a504), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ritonavir | Sirolimus | |
|---|---|---|
| Labeled for | HIV | Organ transplant rejection |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.607 per tablet 100 mg tablet | $0.723 per tablet 1 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once