What the FDA labels say about taking them together
Fluoxetine and ritonavir
Ritonavir's FDA label of July 23, 2026 names fluoxetine in its drug interactions section; the fluoxetine label PlainMeds reads does not name ritonavir. The ritonavir label: “A dose decrease may be needed for these drugs when co-administered with ritonavir.”
Check it at the source: the fluoxetine FDA label on DailyMed (effective January 8, 2026, Dista Products Company); the ritonavir FDA label on DailyMed (effective July 23, 2026, AbbVie Inc.).
What does the fluoxetine label say about ritonavir?
Fluoxetine's label (effective January 8, 2026) does not name ritonavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Prozac), NDA018936 (Eli Lilly And Co), as published by Dista Products Company, effective January 8, 2026 (SPL set c88f33ed-6dfb-4c5e-bc01-d8e36dd97299), via openFDA; the full label on DailyMed
What does the ritonavir label say about fluoxetine?
Ritonavir label, drug interactionsConcomitant Drug Class/Drug Name: Antidepressants: nefazodone, selective serotonin reuptake inhibitors (SSRIs): e.g. fluoxetine, paroxetine, tricyclics: e.g. amitriptyline, nortriptyline; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ antidepressants; Clinical Comment: A dose decrease may be needed for these drugs when co-administered with ritonavir.
Source: FDA drug label (Norvir), AbbVie Inc., effective July 23, 2026 (SPL set 2849298e-de6e-47bb-8194-56e075b33fc3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fluoxetine | Ritonavir | |
|---|---|---|
| Labeled for | Depression, Anxiety, Bipolar disorder | HIV |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0519 per capsule 40 mg capsule | $0.607 per tablet 100 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once