What the FDA labels say about taking them together
Ritonavir and tolvaptan
Tolvaptan's FDA label (Jynarque) of November 6, 2025 names ritonavir in its warnings and precautions section; the ritonavir label PlainMeds reads does not name tolvaptan. The tolvaptan label: “Inhibitors of CYP3A Concomitant use of JYNARQUE with drugs that are moderate or strong CYP3A inhibitors increases tolvaptan exposure.”
Check it at the source: the ritonavir FDA label on DailyMed (effective July 23, 2026, AbbVie Inc.); the tolvaptan FDA label on DailyMed (effective May 7, 2026, Otsuka America Pharmaceutical, Inc.).
What does the ritonavir label say about tolvaptan?
Ritonavir's label (effective July 23, 2026) does not name tolvaptan in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Norvir), AbbVie Inc., effective July 23, 2026 (SPL set 2849298e-de6e-47bb-8194-56e075b33fc3), via openFDA; the full label on DailyMed
What does the tolvaptan label say about ritonavir?
Jynarque label (Otsuka America Pharmaceutical, Inc., November 6, 2025), warnings and precautionsInhibitors of CYP3A Concomitant use of JYNARQUE with drugs that are moderate or strong CYP3A inhibitors (e.g., ketoconazole, itraconazole, lopinavir/ritonavir, indinavir/ritonavir, ritonavir, and conivaptan) increases tolvaptan exposure [see Drug Interactions (7.1) and Clinical Pharmacology (12.3) ].
Source: FDA drug label (Jynarque, NDA204441), Otsuka America Pharmaceutical, Inc., effective November 6, 2025 (SPL set 3febc0a1-9e5a-4ce0-843d-210f21d862c4), via openFDA
Source: FDA drug label (SAMSCA), Otsuka America Pharmaceutical, Inc., effective May 7, 2026 (SPL set 5526617c-c7b9-4556-886d-729bbabbc566), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ritonavir | Tolvaptan | |
|---|---|---|
| Labeled for | HIV | n/a |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.607 per tablet 100 mg tablet | $14.57 per tablet 15 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once