What the FDA labels say about taking them together
Ritonavir and triazolam
Ritonavir's FDA label of July 23, 2026 names triazolam in its contraindications section, and triazolam's label names ritonavir too. The ritonavir label: “Contraindicated due to potential for prolonged or increased sedation or respiratory depression.”
Check it at the source: the ritonavir FDA label on DailyMed (effective July 23, 2026, AbbVie Inc.); the triazolam FDA label on DailyMed (effective July 10, 2026, Mylan Pharmaceuticals Inc.).
What does the ritonavir label say about triazolam?
Ritonavir label, contraindications… Inhibitor: lomitapide ○ Non-opioid Analgesic (selective blocker of Na v 1.8 sodium channels): suzetrigine ○ PDE5 Inhibitor: sildenafil (Revatio ® ) when used for the treatment of pulmonary arterial hypertension ○ Sedative/Hypnotics: triazolam, orally administered midazolam
Ritonavir label, drug interactionsConcomitant Drug Class/Drug Name: Sedative/Hypnotics: triazolam, orally administered midazolam; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ triazolam ↑ midazolam; Clinical Comment: Contraindicated due to potential for prolonged or increased sedation or respiratory depression [see Contraindications () ].
Source: FDA drug label (Norvir), AbbVie Inc., effective July 23, 2026 (SPL set 2849298e-de6e-47bb-8194-56e075b33fc3), via openFDA; the full label on DailyMed
What does the triazolam label say about ritonavir?
Triazolam label, contraindicationsConcomitant administration of strong cytochrome P450 (CYP 3A) enzyme inhibitors (e.g., ketoconazole, itraconazole, nefazodone, lopinavir, ritonavir) [see Warnings and Precautions (5.8), Drug Interactions (7.1) ]. Known hypersensitivity to triazolam or other benzodiazepines
Triazolam label, warnings and precautionsStrong CYP 3A Inhibitors Triazolam is contraindicated in patients receiving strong inhibitors of CYP 3A such as ketoconazole, itraconazole, nefazodone, ritonavir, indinavir, nelfinavir, saquinavir, and lopinavir [see Contraindications (4), Drug Interactions (7.1) ].
Source: FDA drug label (Triazolam), NDA017892 (Pfizer), as published by Mylan Pharmaceuticals Inc., effective July 10, 2026 (SPL set 5add318e-11b9-42f8-b052-0d8cebb32fcf), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ritonavir | Triazolam | |
|---|---|---|
| Labeled for | HIV | Insomnia |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.607 per tablet 100 mg tablet | $0.308 per tablet 0.25 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once