What the FDA labels say about taking them together
Nortriptyline and ritonavir
Ritonavir's FDA label of July 23, 2026 names nortriptyline in its drug interactions section; the nortriptyline label PlainMeds reads does not name ritonavir. The ritonavir label: “A dose decrease may be needed for these drugs when co-administered with ritonavir.”
Check it at the source: the nortriptyline FDA label on DailyMed (effective December 4, 2024); the ritonavir FDA label on DailyMed (effective July 23, 2026, AbbVie Inc.).
What does the nortriptyline label say about ritonavir?
Nortriptyline's label (effective December 4, 2024) does not name ritonavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (PAMELOR), SpecGx LLC, effective December 4, 2024 (SPL set e17dc299-f52d-414d-ab6e-e809bd6f8acb), via openFDA; the full label on DailyMed
What does the ritonavir label say about nortriptyline?
Ritonavir label, drug interactionsConcomitant Drug Class/Drug Name: Antidepressants: nefazodone, selective serotonin reuptake inhibitors (SSRIs): e.g. fluoxetine, paroxetine, tricyclics: e.g. amitriptyline, nortriptyline; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ antidepressants; Clinical Comment: A dose decrease may be needed for these drugs when co-administered with ritonavir.
Source: FDA drug label (Norvir), AbbVie Inc., effective July 23, 2026 (SPL set 2849298e-de6e-47bb-8194-56e075b33fc3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Nortriptyline | Ritonavir | |
|---|---|---|
| Labeled for | Depression | HIV |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.113 per capsule 10 mg capsule | $0.607 per tablet 100 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once