What the FDA labels say about taking them together
Ritonavir and suzetrigine
Ritonavir's FDA label of July 23, 2026 names suzetrigine in its contraindications section; the suzetrigine label PlainMeds reads does not name ritonavir. The ritonavir label: “Co-administration contraindicated due to potential for serious and/or life-threatening suzetrigine adverse reactions.”
Check it at the source: the ritonavir FDA label on DailyMed (effective July 23, 2026, AbbVie Inc.); the suzetrigine FDA label on DailyMed (effective April 13, 2026, Vertex Pharmaceuticals Incorporated).
What does the ritonavir label say about suzetrigine?
Ritonavir label, contraindications… methylergonovine ○ GI Motility Agent: cisapride ○ HMG-CoA Reductase Inhibitors: lovastatin, simvastatin ○ Microsomal triglyceride transfer protein (MTTP) Inhibitor: lomitapide ○ Non-opioid Analgesic (selective blocker of Na v 1.8 sodium channels): suzetrigine ○ PDE5 Inhibitor: sildenafil (Revatio ® ) when used for the treatment of pulmonary arterial hypertension ○ Sedative/Hypnotics: triazolam, orally administered midazolam
Ritonavir label, drug interactionsConcomitant Drug Class/Drug Name: Analgesics, Non-opioid (selective blocker of Na v 1.8 sodium channels) suzetrigine; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ suzetrigine and active metabolite M6-SUZ; Clinical Comment: Co-administration contraindicated due to potential for serious and/or life-threatening suzetrigine adverse reactions [see Contraindications () ].
Source: FDA drug label (Norvir), AbbVie Inc., effective July 23, 2026 (SPL set 2849298e-de6e-47bb-8194-56e075b33fc3), via openFDA; the full label on DailyMed
What does the suzetrigine label say about ritonavir?
Suzetrigine's label (effective April 13, 2026) does not name ritonavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (JOURNAVX), Vertex Pharmaceuticals Incorporated, effective April 13, 2026 (SPL set f0976da4-1d20-4517-945c-b60ed2f41c12), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ritonavir | Suzetrigine | |
|---|---|---|
| Labeled for | HIV | Pain |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.607 per tablet 100 mg tablet | $15.41 per tablet 50 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once