What the FDA labels say about taking them together
Desipramine and ritonavir
Ritonavir's FDA label of July 23, 2026 names desipramine in its drug interactions section; the desipramine labels PlainMeds reads (2) do not name ritonavir. The ritonavir label: “Dosage reduction and concentration monitoring of desipramine is recommended.”
Check it at the source: the desipramine FDA label on DailyMed (effective July 9, 2025, Alembic Pharmaceuticals Inc.); the ritonavir FDA label on DailyMed (effective July 23, 2026, AbbVie Inc.).
What does the desipramine label say about ritonavir?
Desipramine's label (effective July 9, 2025) and its 1 other brand-application label do not name ritonavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (DESIPRAMINE HYDROCHLORIDE), Alembic Pharmaceuticals Inc., effective July 9, 2025 (SPL set cad14805-64d8-4257-b5f1-d56e0063f0e2), via openFDA; the full label on DailyMed
What does the ritonavir label say about desipramine?
Ritonavir label, drug interactionsConcomitant Drug Class/Drug Name: Antidepressant: desipramine; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ desipramine; Clinical Comment: Dosage reduction and concentration monitoring of desipramine is recommended.
Source: FDA drug label (Norvir), AbbVie Inc., effective July 23, 2026 (SPL set 2849298e-de6e-47bb-8194-56e075b33fc3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Desipramine | Ritonavir | |
|---|---|---|
| Labeled for | Depression | HIV |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.276 per tablet 75 mg tablet | $0.607 per tablet 100 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once