What the FDA labels say about taking them together
Elagolix and ritonavir
Ritonavir's FDA label of July 23, 2026 names elagolix in its drug interactions section; the elagolix label PlainMeds reads does not name ritonavir. The ritonavir label: “Concomitant use of elagolix 200 mg twice daily and NORVIR for more than 1 month is not recommended due to potential risk of adverse events such as bone loss and hepatic transaminase elevations. …”
Check it at the source: the elagolix FDA label on DailyMed (effective December 19, 2025, AbbVie Inc.); the ritonavir FDA label on DailyMed (effective July 23, 2026, AbbVie Inc.).
What does the elagolix label say about ritonavir?
Elagolix's label (effective December 19, 2025) does not name ritonavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Orilissa), AbbVie Inc., effective December 19, 2025 (SPL set a86757b3-09c5-fd3b-1223-244e94f50a66), via openFDA; the full label on DailyMed
What does the ritonavir label say about elagolix?
Ritonavir label, drug interactionsConcomitant Drug Class/Drug Name: GnRH Receptor Antagonists: elagolix; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ elagolix ↓ ritonavir; Clinical Comment: Concomitant use of elagolix 200 mg twice daily and NORVIR for more than 1 month is not recommended due to potential risk of adverse events such as bone loss and hepatic transaminase elevations. Limit concomitant use of elagolix 150 mg once daily and NORVIR to 6 months.
Source: FDA drug label (Norvir), AbbVie Inc., effective July 23, 2026 (SPL set 2849298e-de6e-47bb-8194-56e075b33fc3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Elagolix | Ritonavir | |
|---|---|---|
| Labeled for | n/a | HIV |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $43.81 per tablet 150 mg tablet | $0.607 per tablet 100 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once