What the FDA labels say about taking them together
Divalproex and ritonavir
Divalproex's FDA label of March 31, 2026 names ritonavir in its drug interactions section, and ritonavir's label names divalproex too. The ritonavir label: “A dose increase may be needed for these drugs when co-administered with ritonavir and therapeutic concentration monitoring is recommended for these anticonvulsants, if available.”
Check it at the source: the divalproex FDA label on DailyMed (effective March 31, 2026, AbbVie Inc.); the ritonavir FDA label on DailyMed (effective July 23, 2026, AbbVie Inc.).
What does the divalproex label say about ritonavir?
Divalproex label, drug interactionsDrugs on Valproate Clearance Drugs that affect the level of expression of hepatic enzymes, particularly those that elevate levels of glucuronosyltransferases (such as ritonavir), may increase the clearance of valproate.
Source: FDA drug label (Depakote), AbbVie Inc., effective March 31, 2026 (SPL set 08a65cf4-7749-4ceb-6895-8f4805e2b01f), via openFDA; the full label on DailyMed
What does the ritonavir label say about divalproex?
Ritonavir label, drug interactionsConcomitant Drug Class/Drug Name: Anticonvulsants: divalproex, lamotrigine, phenytoin; Effect on Concentration of Ritonavir or Concomitant Drug: ↓ anticonvulsants; Clinical Comment: A dose increase may be needed for these drugs when co-administered with ritonavir and therapeutic concentration monitoring is recommended for these anticonvulsants, if available.
Source: FDA drug label (Norvir), AbbVie Inc., effective July 23, 2026 (SPL set 2849298e-de6e-47bb-8194-56e075b33fc3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Divalproex | Ritonavir | |
|---|---|---|
| Labeled for | Bipolar disorder, Migraine, Seizures and epilepsy | HIV |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.194 per tablet 500 mg tablet | $0.607 per tablet 100 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once