What the FDA labels say about taking them together
Avanafil and ritonavir
Avanafil's FDA label of December 17, 2025 names ritonavir in its drug interactions section, and ritonavir's label names avanafil too. The ritonavir label: “… abnormalities, hypotension, prolonged erection, and syncope. Do not use ritonavir with avanafil because a safe and effective avanafil dosage regimen has not been established. …”
Check it at the source: the avanafil FDA label on DailyMed (effective December 17, 2025, Camber Pharmaceuticals, Inc.); the ritonavir FDA label on DailyMed (effective July 23, 2026, AbbVie Inc.).
What does the avanafil label say about ritonavir?
Avanafil label, drug interactionsCYP3A4 inhibitors (e.g., ketoconazole, ritonavir, erythromycin) increase avanafil exposure
Avanafil label, warnings and precautionsFor patients taking concomitant strong CYP3A4 inhibitors (including ketoconazole, ritonavir, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, saquinavir and telithromycin), do not use avanafil [see Drug Interactions ( 7.2 )].
Source: FDA drug label (Avanafil), ANDA209266 (Hetero Labs Ltd V), as published by Camber Pharmaceuticals, Inc., effective December 17, 2025 (SPL set 1d04e17d-7399-430a-a8bb-fa1912b155e9), via openFDA; the full label on DailyMed
What does the ritonavir label say about avanafil?
Ritonavir label, drug interactionsConcomitant Drug Class/Drug Name: PDE5 Inhibitors: avanafil sildenafil, tadalafil, vardenafil; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ avanafil ↑ sildenafil ↑ tadalafil ↑ vardenafil; Clinical Comment: Sildenafil when used for the treatment of pulmonary arterial hypertension (Revatio ®) is contraindicated due to the potential for sildenafil-associated adverse events, including visual abnormalities, hypotension, prolonged erection, and syncope [see Contraindications () ]. Do not use ritonavir with avanafil because a safe and effective avanafil dosage regimen has not been established. …
Source: FDA drug label (Norvir), AbbVie Inc., effective July 23, 2026 (SPL set 2849298e-de6e-47bb-8194-56e075b33fc3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Avanafil | Ritonavir | |
|---|---|---|
| Labeled for | Erectile dysfunction | HIV |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $50.00 per tablet 200 mg tablet | $0.607 per tablet 100 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once