What the FDA labels say about taking them together
Paroxetine and ritonavir
Paroxetine's FDA label of February 12, 2026 names ritonavir in its drug interactions section, and ritonavir's label names paroxetine too. The paroxetine label: “Monitor clinical effect of BRISDELLE. No BRISDELLE dosage adjustment is needed.”
Check it at the source: the paroxetine FDA label on DailyMed (effective February 12, 2026, Mylan Pharmaceuticals Inc.); the ritonavir FDA label on DailyMed (effective July 23, 2026, AbbVie Inc.).
What does the paroxetine label say about ritonavir?
Paroxetine label, drug interactionsClinical Impact; Co-administration of fosamprenavir/ritonavir with paroxetine tablets significantly decreased plasma levels of paroxetine.
Paroxetine Hydrochloride label (Apotex Corp, September 16, 2026), drug interactionsFosamprenavir/Ritonavir Clinical Impact Co-administration of fosamprenavir/ritonavir with paroxetine significantly decreased plasma levels of paroxetine. Intervention Any dose adjustment should be guided by clinical effect (tolerability and efficacy).
Brisdelle label (Legacy Pharma USA, Inc., April 28, 2025), drug interactionsConcomitant Drug Name: Fosamprenavir/Ritonavir; Effect of Concomitant Drug on Paroxetine: Decreased plasma concentration of paroxetine; Clinical Recommendations: Monitor clinical effect of BRISDELLE. No BRISDELLE dosage adjustment is needed.
Source: FDA drug label (Paroxetine Hydrochloride, NDA020936), Apotex Corp, effective September 16, 2026 (SPL set 087ff0d3-1761-47ea-a8c1-7c4cb679af97), via openFDA
Source: FDA drug label (Brisdelle, NDA204516), Legacy Pharma USA, Inc., effective April 28, 2025 (SPL set 502311b3-b617-4cbd-a3ab-a60f2c62880a), via openFDA
Source: FDA drug label (Paxil, NDA020031), Apotex Corp, effective October 22, 2024 (SPL set ef3b5cbe-f9e1-c1ac-79da-cfe14e3a7e7e), via openFDA
Source: FDA drug label (Paroxetine), Mylan Pharmaceuticals Inc., effective February 12, 2026 (SPL set 89dd7e24-85fc-4152-89ea-47ec2b48a1ed), via openFDA; the full label on DailyMed
What does the ritonavir label say about paroxetine?
Ritonavir label, drug interactionsConcomitant Drug Class/Drug Name: Antidepressants: nefazodone, selective serotonin reuptake inhibitors (SSRIs): e.g. fluoxetine, paroxetine, tricyclics: e.g. amitriptyline, nortriptyline; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ antidepressants; Clinical Comment: A dose decrease may be needed for these drugs when co-administered with ritonavir.
Source: FDA drug label (Norvir), AbbVie Inc., effective July 23, 2026 (SPL set 2849298e-de6e-47bb-8194-56e075b33fc3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Paroxetine | Ritonavir | |
|---|---|---|
| Labeled for | Depression, Anxiety, Menopause symptoms | HIV |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0611 per tablet 20 mg tablet | $0.607 per tablet 100 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once