What the FDA labels say about taking them together
Lurasidone and ritonavir
Lurasidone's FDA label of January 31, 2025 names ritonavir in its contraindications section, and ritonavir's label names lurasidone too. The lurasidone label: “Concomitant use of LATUDA with strong CYP3A4 inhibitors increased the exposure of lurasidone compared to the use of LATUDA alone.”
Check it at the source: the lurasidone FDA label on DailyMed (effective January 31, 2025, Sumitomo Pharma America, Inc.); the ritonavir FDA label on DailyMed (effective July 23, 2026, AbbVie Inc.).
What does the lurasidone label say about ritonavir?
Lurasidone label, contraindicationsStrong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, ritonavir, voriconazole, mibefradil, etc.) [see Drug Interactions ( 7.1 )].
Lurasidone label, drug interactionsStrong CYP3A4 Inhibitors Clinical Impact: Concomitant use of LATUDA with strong CYP3A4 inhibitors increased the exposure of lurasidone compared to the use of LATUDA alone. Intervention: LATUDA should not be used concomitantly with strong CYP3A4 inhibitors [see Contraindications ()]. Examples: Ketoconazole, clarithromycin, ritonavir, voriconazole, mibefradil
Source: FDA drug label (Latuda), NDA200603 (Sunovion Pharms Inc), as published by Sumitomo Pharma America, Inc., effective January 31, 2025 (SPL set afad3051-9df2-4c54-9684-e8262a133af8), via openFDA; the full label on DailyMed
What does the ritonavir label say about lurasidone?
Ritonavir label, contraindicationsNORVIR is contraindicated with drugs that are highly dependent on CYP3A for clearance and for which elevated plasma concentrations are associated with serious and/or life-threatening reactions [see Drug Interactions ( 7.1 ) and Clinical Pharmacology ( 12.3 )]. ○ Alpha 1- Adrenoreceptor Antagonist: alfuzosin ○ Antianginal: ranolazine ○ Antiarrhythmics: amiodarone, dronedarone, flecainide, propafenone, quinidine ○ Antifungal: voriconazole ○ Anti-gout: colchicine ○ Antipsychotics: lurasidone, pimozide ○ Ergot Derivatives: dihydroergotamine, ergotamine, methylergonovine ○ GI Motility Agent: cisapride ○ HMG-CoA Reductase Inhibitors: lovastatin, simvastatin ○ Microsomal triglyceride transfer …
Ritonavir label, drug interactionsConcomitant Drug Class/Drug Name: Antipsychotics: lurasidone pimozide; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ lurasidone ↑ pimozide; Clinical Comment: Contraindicated due to potential for serious and/or life-threatening reactions [see Contraindications () ]. Contraindicated due to potential for serious and/or life-threatening reactions such as cardiac arrhythmias [see Contraindications () ].
Source: FDA drug label (Norvir), AbbVie Inc., effective July 23, 2026 (SPL set 2849298e-de6e-47bb-8194-56e075b33fc3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Lurasidone | Ritonavir | |
|---|---|---|
| Labeled for | Schizophrenia, Bipolar disorder, Depression | HIV |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.142 per tablet 20 mg tablet | $0.607 per tablet 100 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once