What the FDA labels say about taking them together
Posaconazole and ritonavir
Posaconazole's FDA label of August 3, 2026 names ritonavir in its drug interactions section; the ritonavir label PlainMeds reads does not name posaconazole. The posaconazole label: “Mechanism and Clinical Effect (s); Ritonavir and atazanavir are CYP3A4 substrates and posaconazole increased plasma concentrations of these drugs.”
Check it at the source: the posaconazole FDA label on DailyMed (effective August 3, 2026, Aurobindo Pharma Limited); the ritonavir FDA label on DailyMed (effective July 23, 2026, AbbVie Inc.).
What does the posaconazole label say about ritonavir?
Posaconazole label, drug interactionsMechanism and Clinical Effect (s); Ritonavir and atazanavir are CYP3A4 substrates and posaconazole increased plasma concentrations of these drugs [see ].
Source: FDA drug label (POSACONAZOLE), Aurobindo Pharma Limited, effective August 3, 2026 (SPL set f8a26673-261c-4e8e-b1e1-9e23aaf7f285), via openFDA; the full label on DailyMed
What does the ritonavir label say about posaconazole?
Ritonavir's label (effective July 23, 2026) does not name posaconazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Norvir), AbbVie Inc., effective July 23, 2026 (SPL set 2849298e-de6e-47bb-8194-56e075b33fc3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Posaconazole | Ritonavir | |
|---|---|---|
| Labeled for | Fungal infections | HIV |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $2.03 per tablet 100 mg tablet | $0.607 per tablet 100 mg tablet |
| Shortage now | A presentation being discontinued | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once