What the FDA labels say about taking them together
Loperamide and ritonavir
Loperamide's FDA label of June 3, 2026 names ritonavir in its drug interactions (prescription label) section; ritonavir's label does not name loperamide itself but warns about its class (Opioids (opioid agonists)). The loperamide label: “DRUG INTERACTIONS Effects of Other Drugs on Loperamide Concomitant use of Loperamide Hydrochloride Capsules with inhibitors of CYP3A4 (e.g., itraconazole) or CYP2C8 (e.g., gemfibrozil) or inhibitors of P-glycoprotein …”
Check it at the source: the loperamide FDA label on DailyMed (effective June 3, 2026, Aurobindo Pharma Limited); the ritonavir FDA label on DailyMed (effective July 23, 2026, AbbVie Inc.).
What does the loperamide label say about ritonavir?
Loperamide label, drug interactions (prescription label)DRUG INTERACTIONS Effects of Other Drugs on Loperamide Concomitant use of Loperamide Hydrochloride Capsules with inhibitors of CYP3A4 (e.g., itraconazole) or CYP2C8 (e.g., gemfibrozil) or inhibitors of P-glycoprotein (e.g., quinidine, ritonavir) can increase exposure to loperamide.
Source: FDA drug label (Loperamide Hydrochloride), Aurobindo Pharma Limited, effective June 3, 2026 (SPL set 8e4004be-bf79-4631-9e38-c4e7b6726313), via openFDA; the full label on DailyMed
What does the ritonavir label say about loperamide?
Ritonavir's label does not name loperamide itself; it warns about its class (Opioids (opioid agonists)):
Ritonavir label, drug interactionsAnalgesics, Opioid: tramadol, propoxyphene, methadone, fentanyl ↑ analgesics ↓ methadone ↑ fentanyl A dose decrease may be needed for these drugs when co-administered with ritonavir.
Source: FDA drug label (Norvir), AbbVie Inc., effective July 23, 2026 (SPL set 2849298e-de6e-47bb-8194-56e075b33fc3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Loperamide | Ritonavir | |
|---|---|---|
| Labeled for | Diarrhea | HIV |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0549 per capsule 2 mg capsule | $0.607 per tablet 100 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once