What the FDA labels say about taking them together
Metoprolol and ritonavir
Ritonavir's FDA label of July 23, 2026 names metoprolol in its drug interactions section; the metoprolol labels PlainMeds reads (4) do not name ritonavir. The ritonavir label: “Caution is warranted and clinical monitoring of patients is recommended. A dose decrease may be needed for these drugs when co-administered with ritonavir.”
Check it at the source: the metoprolol FDA label on DailyMed (effective March 3, 2026, Melinta Therapeutics, LLC); the ritonavir FDA label on DailyMed (effective July 23, 2026, AbbVie Inc.).
What does the metoprolol label say about ritonavir?
Metoprolol's label (effective March 3, 2026) and its 3 other brand-application labels do not name ritonavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (TOPROL XL), Melinta Therapeutics, LLC, effective March 3, 2026 (SPL set 496ddfaa-7c9c-4888-b747-a210249b367a), via openFDA; the full label on DailyMed
What does the ritonavir label say about metoprolol?
Ritonavir label, drug interactionsConcomitant Drug Class/Drug Name: β-Blockers: metoprolol, timolol; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ beta-blockers; Clinical Comment: Caution is warranted and clinical monitoring of patients is recommended. A dose decrease may be needed for these drugs when co-administered with ritonavir.
Source: FDA drug label (Norvir), AbbVie Inc., effective July 23, 2026 (SPL set 2849298e-de6e-47bb-8194-56e075b33fc3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Metoprolol | Ritonavir | |
|---|---|---|
| Labeled for | High blood pressure, Angina, Heart failure, Heart attack and coronary artery disease | HIV |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.085 per tablet 100 mg tablet | $0.607 per tablet 100 mg tablet |
| Shortage now | A presentation being discontinued | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once