What the FDA labels say about taking them together
Colchicine and ritonavir
Colchicine's FDA label (Lodoco) of August 13, 2026 names ritonavir in its drug interactions section, and ritonavir's label names colchicine too. The colchicine label: “Significant increases in colchicine plasma levels.”
Check it at the source: the colchicine FDA label on DailyMed (effective July 22, 2025, Aurobindo Pharma Limited); the ritonavir FDA label on DailyMed (effective July 23, 2026, AbbVie Inc.).
What does the colchicine label say about ritonavir?
Lodoco label (AGEPHA Pharma USA, LLC, August 13, 2026), drug interactionsDrug class: Strong CYP3A4 Inhibitors † atazanavir clarithromycin darunavir/ritonavir indinavir itraconazole ketoconazole lopinavir/ritonavir nefazodone nelfinavir ritonavir saquinavir telithromycin tipranavir/ritonavir; Outcome/effect: Significant increases in colchicine plasma levels [see Clinical Pharmacology (12.3)].; Clinical comment: Concomitant use of LODOCO with strong CYP3A4 inhibitors is contraindicated [see Contraindications (4)].
Source: FDA drug label (Lodoco, NDA215727), AGEPHA Pharma USA, LLC, effective August 13, 2026 (SPL set ff06d68f-d65f-d097-e053-6294a90a7e5f), via openFDA
Source: FDA drug label (Colchicine), Aurobindo Pharma Limited, effective July 22, 2025 (SPL set dd93a40f-92ab-47ac-9083-b8a7a0b18ad6), via openFDA; the full label on DailyMed
What does the ritonavir label say about colchicine?
Ritonavir label, contraindicationsNORVIR is contraindicated with drugs that are highly dependent on CYP3A for clearance and for which elevated plasma concentrations are associated with serious and/or life-threatening reactions [see Drug Interactions ( 7.1 ) and Clinical Pharmacology ( 12.3 )]. ○ Alpha 1- Adrenoreceptor Antagonist: alfuzosin ○ Antianginal: ranolazine ○ Antiarrhythmics: amiodarone, dronedarone, flecainide, propafenone, quinidine ○ Antifungal: voriconazole ○ Anti-gout: colchicine ○ Antipsychotics: lurasidone, pimozide ○ Ergot Derivatives: dihydroergotamine, ergotamine, methylergonovine ○ GI Motility Agent: cisapride ○ HMG-CoA Reductase Inhibitors: lovastatin, simvastatin ○ Microsomal triglyceride transfer …
Ritonavir label, drug interactionsConcomitant Drug Class/Drug Name: Anti-gout: colchicine; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ colchicine; Clinical Comment: Contraindicated due to potential for serious and/or life-threatening reactions in patients with renal and/or hepatic impairment [see Contraindications () ]. For patients with normal renal or hepatic function: Treatment of gout flares-co-administration of colchicine in patients on ritonavir: 0.6 mg (one tablet) for one dose, followed by 0.3 mg (half tablet) one hour later. Dose to be repeated no earlier than three days. …
Source: FDA drug label (Norvir), AbbVie Inc., effective July 23, 2026 (SPL set 2849298e-de6e-47bb-8194-56e075b33fc3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Colchicine | Ritonavir | |
|---|---|---|
| Labeled for | Gout | HIV |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.122 per tablet 0.6 mg tablet | $0.607 per tablet 100 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once