What the FDA labels say about taking them together
Estazolam and ritonavir
Ritonavir's FDA label of July 23, 2026 names estazolam in its drug interactions section; the estazolam label PlainMeds reads does not name ritonavir. The ritonavir label: “A dose decrease may be needed for these drugs when co-administered with ritonavir.”
Check it at the source: the estazolam FDA label on DailyMed (effective November 11, 2022, Novitium Pharma LLC); the ritonavir FDA label on DailyMed (effective July 23, 2026, AbbVie Inc.).
What does the estazolam label say about ritonavir?
Estazolam's label (effective November 11, 2022) does not name ritonavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Estazolam), Novitium Pharma LLC, effective November 11, 2022 (SPL set e1c77eb1-9cba-4e89-a03f-9fb797add4f0), via openFDA; the full label on DailyMed
What does the ritonavir label say about estazolam?
Ritonavir label, drug interactionsConcomitant Drug Class/Drug Name: Sedative/hypnotics: buspirone, clorazepate, diazepam, estazolam, flurazepam, zolpidem; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ sedative/hypnotics; Clinical Comment: A dose decrease may be needed for these drugs when co-administered with ritonavir.
Source: FDA drug label (Norvir), AbbVie Inc., effective July 23, 2026 (SPL set 2849298e-de6e-47bb-8194-56e075b33fc3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Estazolam | Ritonavir | |
|---|---|---|
| Labeled for | Insomnia | HIV |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.839 per tablet 2 mg tablet | $0.607 per tablet 100 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once