What the FDA labels say about taking them together
Mometasone and ritonavir
Mometasone's FDA label of August 19, 2026 names ritonavir in its drug interactions (prescription label) section, and ritonavir's label names mometasone too. The ritonavir label: “Coadministration with corticosteroids whose exposures are significantly increased by strong CYP3A inhibitors can increase the risk for Cushing’s syndrome and adrenal suppression.Alternative corticosteroids including …”
Check it at the source: the mometasone FDA label on DailyMed (effective August 19, 2026, L. Perrigo Company); the ritonavir FDA label on DailyMed (effective July 23, 2026, AbbVie Inc.).
What does the mometasone label say about ritonavir?
Mometasone label, drug interactions (prescription label)Caution should be exercised when considering the coadministration of mometasone furoate monohydrate nasal spray with long-term ketoconazole and other known strong CYP3A4 inhibitors (e.g., ritonavir, cobicistat-containing products, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, saquinavir, telithromycin) [see Clinical Pharmacology (12.3) ].
Mometasone label, warningsmedicine for HIV infection (such as ritonavir)
Asmanex Hfa label (Organon LLC, July 7, 2026), drug interactionsStrong cytochrome P450 3A4 inhibitors (e.g., ritonavir): Use with caution.
Asmanex Hfa label (Organon LLC, July 7, 2026), warnings and precautionsIf such changes occur, discontinue ASMANEX HFA slowly. ( 5.5 ) Strong cytochrome P450 3A4 inhibitors (e.g., ritonavir):
Asmanex label (Organon LLC, July 7, 2026), warnings and precautionsTreat bronchospasm immediately with a fast-acting inhaled bronchodilator and discontinue use of ASMANEX TWISTHALER. ( 5.10 ) Strong cytochrome P450 3A4 inhibitors (e.g., ritonavir):
Source: FDA drug label (Asmanex Hfa, NDA205641), Organon LLC, effective July 7, 2026 (SPL set 0c6d63da-41bc-4894-bead-198e66c848ac), via openFDA
Source: FDA drug label (Nasonex), L. Perrigo Company, effective August 19, 2026 (SPL set 13696a8b-366a-4a5e-adea-d5b7bff9e46f), via openFDA; the full label on DailyMed
What does the ritonavir label say about mometasone?
Ritonavir label, drug interactionsConcomitant Drug Class/Drug Name: Systemic/Inhaled/ Nasal/Ophthalmic Corticosteroids: e.g., betamethasone budesonide ciclesonide dexamethasone fluticasone methylprednisolone mometasone prednisone triamcinolone; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ glucocorticoids; Clinical Comment: Coadministration with corticosteroids whose exposures are significantly increased by strong CYP3A inhibitors can increase the risk for Cushing’s syndrome and adrenal suppression.Alternative corticosteroids including beclomethasone and prednisolone (whose PK and/or PD are less affected by strong CYP3A inhibitors relative to other studied steroids) should be considered, particularly for …
Source: FDA drug label (Norvir), AbbVie Inc., effective July 23, 2026 (SPL set 2849298e-de6e-47bb-8194-56e075b33fc3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Mometasone | Ritonavir | |
|---|---|---|
| Labeled for | Allergies, Asthma | HIV |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.354 per gram 0.1% cream | $0.607 per tablet 100 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once