What the FDA labels say about taking them together
Nifedipine and ritonavir
Nifedipine's FDA label of December 24, 2024 names ritonavir in its drug interactions section, and ritonavir's label names nifedipine too. The ritonavir label: “Caution is warranted and clinical monitoring of patients is recommended. A dose decrease may be needed for these drugs when co-administered with ritonavir.”
Check it at the source: the nifedipine FDA label on DailyMed (effective December 24, 2024, Aurobindo Pharma Limited); the ritonavir FDA label on DailyMed (effective July 23, 2026, AbbVie Inc.).
What does the nifedipine label say about ritonavir?
Nifedipine label, drug interactionsCYP3A inhibitors CYP3A inhibitors such as ketoconazole, fluconazole, itraconazole, clarithromycin, erythromycin (Azithromycin, although structurally related to the class of macrolide antibiotic is void of clinically relevant CYP3A4 inhibition), grapefruit, nefazodone, fluoxetine, saquinavir, indinavir, nelfinavir, and ritonavir may result in increased exposure to nifedipine when co-administered.
Source: FDA drug label (Nifedipine), Aurobindo Pharma Limited, effective December 24, 2024 (SPL set eb70b7ff-f9f0-41d0-901a-f4c04ae9ed46), via openFDA; the full label on DailyMed
What does the ritonavir label say about nifedipine?
Ritonavir label, drug interactionsConcomitant Drug Class/Drug Name: Calcium channel blockers: diltiazem, nifedipine, verapamil; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ calcium channel blockers; Clinical Comment: Caution is warranted and clinical monitoring of patients is recommended. A dose decrease may be needed for these drugs when co-administered with ritonavir.
Source: FDA drug label (Norvir), AbbVie Inc., effective July 23, 2026 (SPL set 2849298e-de6e-47bb-8194-56e075b33fc3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Nifedipine | Ritonavir | |
|---|---|---|
| Labeled for | High blood pressure, Angina | HIV |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.130 per tablet 30 mg tablet | $0.607 per tablet 100 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once