What the FDA labels say about taking them together
Ethinyl estradiol/ethynodiol and ritonavir
Ethinyl estradiol/ethynodiol's FDA label of February 5, 2025 names ritonavir in its contraindications section; the ritonavir label PlainMeds reads does not name ethinyl estradiol/ethynodiol. The ethinyl estradiol/ethynodiol label: “… receiving Hepatitis C drug combinations containing ombitasvir/paritaprevir/ritonavir, with or without dasabuvir, due to the potential for ALT elevations.”
Check it at the source: the ethinyl estradiol/ethynodiol FDA label on DailyMed (effective February 5, 2025, Xiromed LLC); the ritonavir FDA label on DailyMed (effective July 23, 2026, AbbVie Inc.).
What does the ethinyl estradiol/ethynodiol label say about ritonavir?
Ethinyl estradiol/ethynodiol label, contraindications… cholestatic jaundice of pregnancy or jaundice with prior oral contraceptive use Past or present, benign or malignant liver tumors Known or suspected pregnancy Are receiving Hepatitis C drug combinations containing ombitasvir/paritaprevir/ritonavir, with or without dasabuvir, due to the potential for ALT elevations (see Warnings, RISK OF LIVER ENZYME ELEVATIONS WITH CONCOMITANT HEPATITIS C TREATMENT).
Ethinyl estradiol/ethynodiol label, warningsRISK OF LIVER ENZYME ELEVATIONS WITH CONCOMITANT HEPATITIS C TREATMENT During clinical trials with the Hepatitis C combination drug regimen that contains ombitasvir/paritaprevir/ritonavir, with or without dasabuvir, ALT elevations greater than 5 times the upper limit of normal (ULN), including some cases greater than 20 times the ULN, were significantly more frequent in women using ethinyl estradiol-containing medications such as CHCs.
Source: FDA drug label (VALTYA 1/50), Xiromed LLC, effective February 5, 2025 (SPL set 1aff28b0-93eb-5e44-9164-d76ffd08cd59), via openFDA; the full label on DailyMed
What does the ritonavir label say about ethinyl estradiol/ethynodiol?
Ritonavir's label (effective July 23, 2026) does not name ethinyl estradiol/ethynodiol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Norvir), AbbVie Inc., effective July 23, 2026 (SPL set 2849298e-de6e-47bb-8194-56e075b33fc3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ethinyl estradiol/ethynodiol | Ritonavir | |
|---|---|---|
| Labeled for | Birth control | HIV |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.379 per tablet 1-35 tablet | $0.607 per tablet 100 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once