Drug side effects

Drug Side Effects

Which side effects are reported to the FDA, for whom, and how often, with demographics, outcomes, and reporting trends across every medication we track.

Compiled by PlainMeds Editorial, Drug Information Editorial Team

Data updated 2026-05-15

524
Medications: 25.5M
FAERS reports

Data from the FDA Adverse Event Reporting System (FAERS). See our methodology.

PlainMeds analyzes 25.5M FDA adverse-event reports across 524 medications to show which side effects are reported, for whom, and how often.

The FDA Adverse Event Reporting System (FAERS) collects voluntary reports of drug side effects from patients, clinicians, and manufacturers. PlainMeds summarizes 25.5M reports across 524 drugs, grouped by drug class with demographics and outcomes. Report volume reflects how often a side effect is reported, which tracks how widely a drug is used, not how likely the effect is for any one person. Educational information, not medical advice.

524

Drugs Analyzed

25.5M

Total Reports

12+

Drug Classes

Most Reported Drugs

#	Drug	Reports	Deaths	Hospital
1	adalimumab TNF-Alpha Inhibitor (Biologic)	695,825	28,962	146,638
2	etanercept TNF-Alpha Inhibitor (Biologic)	591,578	16,504	65,552
3	aspirin Antiplatelet / NSAID	518,554	47,820	203,341
4	prednisone Corticosteroid	482,856	50,090	166,315
5	acetaminophen Analgesic / Antipyretic	417,458	58,910	150,224
6	dupilumab Anti-IL-4/IL-13 Monoclonal Antibody	411,692	1,769	19,011
7	methotrexate Disease-Modifying Antirheumatic Drug (DMARD)	410,053	32,502	115,535
8	furosemide Loop Diuretic	387,984	60,624	190,901
9	ergocalciferol Vitamin D2 Supplement	366,491	21,613	98,409
10	gabapentin Anticonvulsant / Nerve Pain Agent	351,750	33,007	103,305
11	metformin Biguanide	342,023	28,446	122,330
12	omeprazole Proton Pump Inhibitor (PPI)	331,875	30,378	122,601
13	levothyroxine Thyroid Hormone	304,465	19,579	88,368
14	lisinopril ACE Inhibitor	297,692	24,562	95,486
15	dexamethasone Corticosteroid	285,895	46,323	109,720
16	pregabalin Anticonvulsant / Nerve Pain Agent	264,092	21,160	74,751
17	ibuprofen Nonsteroidal Anti-Inflammatory Drug (NSAID)	262,453	17,491	81,556
18	amlodipine Calcium Channel Blocker	257,862	28,135	104,040
19	metoprolol Beta-Blocker	246,252	27,931	96,962
20	simvastatin HMG-CoA Reductase Inhibitor (Statin)	245,754	21,913	94,740
21	folic acid B Vitamin (Folate) Supplement	241,433	22,144	87,188
22	pantoprazole Proton Pump Inhibitor (PPI)	240,800	27,099	111,504
23	atorvastatin HMG-CoA Reductase Inhibitor (Statin)	240,204	18,385	68,513
24	insulin glargine Long-Acting Insulin	236,147	13,233	62,916
25	infliximab TNF-Alpha Inhibitor (Biologic)	211,136	12,983	62,267
26	rivaroxaban Direct Oral Anticoagulant (Factor Xa Inhibitor)	203,269	26,830	102,060
27	alprazolam Benzodiazepine	200,719	32,899	64,280
28	ranitidine H2 Receptor Antagonist	197,405	15,440	25,953
29	levonorgestrel Progestin	197,074	267	10,709
30	denosumab RANK Ligand Inhibitor	196,342	25,105	30,164
31	rosuvastatin HMG-CoA Reductase Inhibitor (Statin)	194,743	11,716	60,611
32	clopidogrel Antiplatelet Agent	192,921	21,408	88,784
33	quetiapine Atypical Antipsychotic	185,533	26,984	67,436
34	tofacitinib JAK Inhibitor	181,998	8,655	24,557
35	oxycodone Opioid Analgesic	180,422	51,490	49,832
36	adapalene Retinoid (Topical)	178,147	32	358
37	lorazepam Benzodiazepine	174,469	25,012	72,527
38	prednisolone Corticosteroid	173,227	27,831	79,445
39	lansoprazole Proton Pump Inhibitor (PPI)	173,086	19,347	62,821
40	losartan Angiotensin II Receptor Blocker (ARB)	165,585	12,034	48,929
41	secukinumab IL-17A Inhibitor (Biologic)	157,236	7,752	20,636
42	clonazepam Benzodiazepine	155,147	18,179	46,031
43	evolocumab PCSK9 Inhibitor	155,068	1,849	7,680
44	allopurinol Xanthine Oxidase Inhibitor	150,998	21,323	74,277
45	apremilast PDE4 Inhibitor	143,174	5,453	10,932
46	hydrochlorothiazide Thiazide Diuretic	140,497	9,873	48,508
47	escitalopram Selective Serotonin Reuptake Inhibitor (SSRI)	134,536	10,908	42,595
48	insulin lispro Rapid-Acting Insulin	134,198	5,906	33,389
49	spironolactone Potassium-Sparing Diuretic / Aldosterone Antagonist	133,996	17,638	64,112
50	citalopram Selective Serotonin Reuptake Inhibitor (SSRI)	133,513	18,674	45,226

By Drug Class

TNF-Alpha Inhibitor (Biologic)

4 drugs 1.6M reports

Corticosteroid

6 drugs 1.2M reports

Proton Pump Inhibitor (PPI)

6 drugs 866,398 reports

Atypical Antipsychotic

12 drugs 745,737 reports

HMG-CoA Reductase Inhibitor (Statin)

7 drugs 731,962 reports

Benzodiazepine

5 drugs 672,218 reports

Disease-Modifying Antirheumatic Drug (DMARD)

4 drugs 660,318 reports

Anticonvulsant / Nerve Pain Agent

2 drugs 615,842 reports

Nonsteroidal Anti-Inflammatory Drug (NSAID)

13 drugs 527,294 reports

Antiplatelet / NSAID

1 drugs 518,554 reports

ACE Inhibitor

8 drugs 491,648 reports

Opioid Analgesic

7 drugs 486,911 reports

All Drugs (524)

adalimumab 695,825 etanercept 591,578 aspirin 518,554 prednisone 482,856 acetaminophen 417,458 dupilumab 411,692 methotrexate 410,053 furosemide 387,984 ergocalciferol 366,491 gabapentin 351,750 metformin 342,023 omeprazole 331,875 levothyroxine 304,465 lisinopril 297,692 dexamethasone 285,895 pregabalin 264,092 ibuprofen 262,453 amlodipine 257,862 metoprolol 246,252 simvastatin 245,754 folic acid 241,433 pantoprazole 240,800 atorvastatin 240,204 insulin glargine 236,147 infliximab 211,136 rivaroxaban 203,269 alprazolam 200,719 ranitidine 197,405 levonorgestrel 197,074 denosumab 196,342 rosuvastatin 194,743 clopidogrel 192,921 quetiapine 185,533 tofacitinib 181,998 oxycodone 180,422 adapalene 178,147 lorazepam 174,469 prednisolone 173,227 lansoprazole 173,086 losartan 165,585 secukinumab 157,236 clonazepam 155,147 evolocumab 155,068 allopurinol 150,998 apremilast 143,174 hydrochlorothiazide 140,497 escitalopram 134,536 insulin lispro 134,198 spironolactone 133,996 citalopram 133,513 abatacept 133,227 methylprednisolone 131,747 zolpidem 131,653 atenolol 130,943 carvedilol 130,791 risperidone 129,958 celecoxib 128,099 levetiracetam 127,698 lamotrigine 127,196 warfarin 124,873 clozapine 121,298 tirzepatide 120,921 ramipril 119,507 aripiprazole 118,365 diazepam 117,869 albuterol 113,967 sertraline 112,198 teriparatide 111,257 famotidine 110,018 acyclovir 109,698 potassium chloride 109,144 cyclosporine 106,440 loratadine 104,378 olanzapine 103,356 ondansetron 103,354 valsartan 102,306 leflunomide 102,095 ustekinumab 98,899 alendronate 98,033 tadalafil 96,629 fentanyl 95,293 polyethylene glycol 3350 91,655 hydromorphone 90,652 buprenorphine 90,121 topiramate 90,083 ciprofloxacin 89,398 mirtazapine 87,759 dulaglutide 85,635 hydrocortisone 84,725 estradiol 83,781 baclofen 83,476 golimumab 82,622 diclofenac 82,165 omalizumab 79,748 montelukast 78,359 sulfasalazine 76,270 naproxen 75,912 amoxicillin 73,430 upadacitinib 72,798 cetirizine 72,729 morphine 72,146 semaglutide 72,117 hydroxychloroquine 71,900 digoxin 70,341 sitagliptin 70,292 ezetimibe 70,203 propranolol 68,257 venlafaxine 68,147 fluconazole 67,703 carbamazepine 65,260 duloxetine 65,067 doxycycline 64,488 calcium carbonate 64,404 fluoxetine 64,119 doxycycline hyclate 63,762 metronidazole 63,731 insulin aspart 63,536 apixaban 62,650 empagliflozin 61,560 epinephrine 61,536 diphenhydramine 60,533 glipizide 59,560 letrozole 59,013 esomeprazole 58,495 levofloxacin 58,038 conjugated estrogens 57,675 enzalutamide 57,614 finasteride 56,567 docusate 55,963 meloxicam 55,835 enoxaparin 55,714 vancomycin 55,549 budesonide 55,389 sildenafil 55,325 enalapril 54,355 metoclopramide 53,266 exenatide 52,302 nitroglycerin 51,859 melatonin 51,370 dapagliflozin 50,521 clonidine 49,370 latanoprost 48,513 fenofibrate 48,091 liraglutide 47,843 ferrous sulfate 47,788 isotretinoin 47,513 cyclobenzaprine 47,426 mepolizumab 47,215 etonogestrel 46,939 metronidazole topical 45,816 nifedipine 45,410 hydroxyzine 44,206 minoxidil 43,650 irbesartan 43,004 loperamide 42,665 pioglitazone 42,504 bupropion 41,778 methadone 41,632 testosterone 40,954 dexlansoprazole 40,790 magnesium oxide 39,831 valacyclovir 39,048 insulin detemir 38,664 zoledronic acid 38,197 glimepiride 37,936 azithromycin 37,361 lactulose 37,033 mirabegron 36,931 temazepam 36,917 sumatriptan 36,885 tramadol 36,174 ixekizumab 35,897 lacosamide 35,350 anastrozole 35,161 donepezil 35,138 diltiazem 33,620 telmisartan 33,611 candesartan 33,477 clarithromycin 33,247 tapentadol 33,054 paroxetine 32,666 oxcarbazepine 31,347 ceftriaxone 31,340 guselkumab 31,164 torsemide 31,122 cyanocobalamin 31,083 ticagrelor 30,895 meropenem 30,400 risedronate 30,089 biotin 29,879 aflibercept 29,874 naltrexone 29,813 canagliflozin 29,554 guaifenesin 29,404 voriconazole 29,380 colchicine 28,502 hydralazine 28,498 oxybutynin 28,434 bimatoprost 28,128 linezolid 28,005 methylphenidate 27,931 clindamycin 27,449 doxazosin 27,049 prochlorperazine 26,613 nystatin 26,244 ranibizumab 26,174 lovastatin 25,229 bumetanide 25,027 linaclotide 24,979 eszopiclone 24,883 abaloparatide 24,667 alirocumab 24,428 lithium 24,367 valbenazine 24,340 midazolam 24,014 glyburide 23,902 sarilumab 23,683 haloperidol 23,495 tobramycin 23,287 clobazam 23,107 sucralfate 23,037 paliperidone 22,775 tizanidine 22,750 ascorbic acid 22,556 cannabidiol 22,227 insulin degludec 22,011 rabeprazole 21,352 methocarbamol 21,191 progesterone 21,004 exemestane 20,856 dutasteride 20,677 cephalexin 20,636 lurasidone 20,544 phenytoin 20,453 calcitriol 20,452 senna 20,197 isosorbide mononitrate 19,947 rifaximin 19,891 fexofenadine 19,831 valproate 19,772 isosorbide dinitrate 19,058 pravastatin 18,936 carisoprodol 18,851 tamsulosin 18,628 erythromycin 18,237 desoximetasone 18,159 valganciclovir 18,056 rivastigmine 17,976 promethazine 17,969 aprepitant 17,740 benralizumab 17,680 amphotericin B 17,512 linagliptin 17,378 ziprasidone 17,328 indapamide 17,199 mometasone 17,186 azelastine 16,672 amitriptyline 16,403 vortioxetine 16,243 amikacin 16,238 ketoconazole 16,231 sotalol 16,062 febuxostat 16,005 esketamine 15,846 lifitegrast 15,783 nitrofurantoin 15,757 brexpiprazole 15,755 meclizine 15,616 benzonatate 15,513 posaconazole 15,332 trazodone 15,113 nebivolol 14,997 gemfibrozil 14,954 darunavir 14,896 ropinirole 14,664 pramipexole 14,399 zonisamide 14,210 vigabatrin 14,085 phenobarbital 13,998 cefepime 13,667 bisacodyl 13,500 rifampin 13,451 moxifloxacin 13,400 dicyclomine 13,367 remdesivir 13,113 ciclesonide 13,075 heparin 12,966 indomethacin 12,919 goserelin 12,855 memantine 12,807 abiraterone 12,794 mupirocin 12,758 labetalol 12,726 gentamicin 12,687 suvorexant 12,687 ketoprofen 12,302 eplerenone 12,113 thiamine 11,724 theophylline 11,723 timolol 11,690 cholestyramine 11,539 niacin 11,382 trimethoprim 11,380 itraconazole 11,311 minocycline 11,257 entecavir 11,247 cefuroxime 11,087 chlorthalidone 11,035 felodipine 11,019 metolazone 10,872 amiodarone 10,687 dofetilide 10,302 desloratadine 10,248 dalteparin 10,243 norepinephrine 10,232 buspirone 10,228 granisetron 10,198 ranolazine 10,014 insulin glulisine 9,944 dronedarone 9,899 ganciclovir 9,877 primidone 9,782 doxepin 9,780 vilazodone 9,764 misoprostol 9,536 pseudoephedrine 9,450 crisaborole 9,400 baricitinib 9,259 cimetidine 9,140 lubiprostone 9,102 meperidine 8,979 cefazolin 8,788 dolutegravir 8,756 cariprazine 8,574 umeclidinium 8,530 triazolam 8,521 brinzolamide 8,461 daptomycin 8,426 travoprost 8,423 liothyronine 8,408 saxagliptin 8,141 phytonadione 8,078 fondaparinux 7,980 atropine 7,881 dronabinol 7,819 icosapent ethyl 7,801 tretinoin 7,629 oseltamivir 7,575 dextromethorphan 7,480 terazosin 7,436 dorzolamide 7,422 methimazole 7,411 ceftazidime 7,404 nadolol 7,398 guanfacine 7,386 cefdinir 7,348 tetrabenazine 7,235 ramelteon 7,215 perampanel 7,188 repaglinide 7,180 ofloxacin 7,063 benazepril 7,061 inclisiran 6,989 chlorpromazine 6,862 terbinafine 6,848 quinapril 6,775 benzoyl peroxide 6,624 ivabradine 6,539 vibegron 6,501 cenobamate 6,460 roflumilast 6,450 deutetrabenazine 6,445 tolterodine 6,323 nabumetone 6,319 chlorpheniramine 6,221 piroxicam 6,176 phentermine 6,109 cilostazol 5,992 ivermectin 5,936 etodolac 5,880 tigecycline 5,878 lisdexamfetamine 5,840 prazosin 5,825 varenicline 5,766 tasimelteon 5,762 bismuth subsalicylate 5,567 nortriptyline 5,503 fluocinonide 5,460 norethindrone 5,342 octreotide 5,230 glycopyrrolate 5,225 potassium citrate 5,207 molnupiravir 5,119 degarelix 4,979 micafungin 4,779 desonide 4,709 methyldopa 4,692 cabergoline 4,670 clomipramine 4,403 brivaracetam 4,286 verapamil 4,224 fosinopril 4,213 nicardipine 4,175 vasopressin 4,135 propafenone 4,113 dexmethylphenidate 4,083 selenium 4,079 entacapone 3,955 fluvastatin 3,948 glucagon 3,944 ertapenem 3,848 acarbose 3,736 dipyridamole 3,682 phenylephrine 3,669 phenazopyridine 3,599 dobutamine 3,554 cromolyn 3,396 alogliptin 3,393 pegloticase 3,350 calcipotriene 3,344 palonosetron 3,330 metaxalone 3,268 desvenlafaxine 3,267 codeine 3,245 atomoxetine 3,228 isavuconazonium 3,219 rasagiline 3,152 pitavastatin 3,148 capsaicin 3,030 dopamine 2,938 ibandronate 2,935 oxytocin 2,902 selegiline 2,896 eluxadoline 2,870 tafluprost 2,845 cefixime 2,824 zinc sulfate 2,699 famciclovir 2,678 colestipol 2,477 rufinamide 2,477 artificial tears 2,450 pyridoxine 2,439 lemborexant 2,425 ethosuximide 2,415 penicillin V 2,398 sulindac 2,380 raloxifene 2,311 fluvoxamine 2,289 fidaxomicin 2,273 prasugrel 2,254 aliskiren 2,229 alfuzosin 2,222 imiquimod 2,179 baloxavir marboxil 2,164 bempedoic acid 2,157 mefenamic acid 2,104 oxaprozin 2,050 perphenazine 2,013 propylthiouracil 1,982 trandolapril 1,978 nabilone 1,963 brodalumab 1,890 levomilnacipran 1,858 plecanatide 1,831 albendazole 1,829 netarsudil 1,797 felbamate 1,714 permethrin 1,707 galantamine 1,577 phenelzine 1,551 adenosine 1,547 pimecrolimus 1,541 zaleplon 1,538 anidulafungin 1,527 nizatidine 1,480 omadacycline 1,476 iloperidone 1,388 leuprolide 1,385 nateglinide 1,302 desipramine 1,275 chlorzoxazone 1,256 acebutolol 1,220 safinamide 1,205 nisoldipine 1,191 probenecid 1,152 tazarotene 1,132 disulfiram 1,076 ertugliflozin 1,037 colesevelam 952 miglitol 923 dalbavancin 911 vericiguat 905 oritavancin 896 asenapine 863 amiloride 834 azelaic acid 826 diflunisal 799 pindolol 774 mebendazole 762 tetracycline 741 diazoxide 705 bromocriptine 637 darifenacin 596 dantrolene 580 isradipine 541 imipramine 537 rolapitant 531 ethacrynic acid 520 pimozide 463 mexiletine 408 tranylcypromine 329 butorphanol 318 acamprosate 299 griseofulvin 278 nalbuphine 218 eravacycline 205 dicloxacillin 178 fluphenazine 108 protriptyline 96 tiagabine 81 alosetron 73 moexipril 67 thioridazine 51 plazomicin 3