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What the FDA labels say about taking them together

Flurazepam and ritonavir

Ritonavir's FDA label of July 23, 2026 names flurazepam in its drug interactions section; the flurazepam label PlainMeds reads does not name ritonavir. The ritonavir label: “A dose decrease may be needed for these drugs when co-administered with ritonavir.”

Check it at the source: the flurazepam FDA label on DailyMed (effective October 28, 2024, Chartwell RX, LLC); the ritonavir FDA label on DailyMed (effective July 23, 2026, AbbVie Inc.).

What does the flurazepam label say about ritonavir?

Flurazepam's label (effective October 28, 2024) does not name ritonavir in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Flurazepam Hydrochloride), Chartwell RX, LLC, effective October 28, 2024 (SPL set 8f476891-1346-4e8c-ac1b-f8cbdc64f5a1), via openFDA; the full label on DailyMed

What does the ritonavir label say about flurazepam?

Ritonavir label, drug interactions

Concomitant Drug Class/Drug Name: Sedative/hypnotics: buspirone, clorazepate, diazepam, estazolam, flurazepam, zolpidem; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ sedative/hypnotics; Clinical Comment: A dose decrease may be needed for these drugs when co-administered with ritonavir.

Source: FDA drug label (Norvir), AbbVie Inc., effective July 23, 2026 (SPL set 2849298e-de6e-47bb-8194-56e075b33fc3), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

1Flurazepam generic labelers
7Ritonavir generic labelers
FlurazepamRitonavir
Labeled forInsomniaHIV
Boxed warningYesYes
Pharmacy cost (NADAC)n/a$0.607 per tablet 100 mg tablet
Shortage nowIn shortageA presentation being discontinued

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?