What the FDA labels say about taking them together
Ritonavir and rivaroxaban
Ritonavir's FDA label of July 23, 2026 names rivaroxaban in its drug interactions section, and rivaroxaban's label names ritonavir too. The ritonavir label: “Avoid concomitant use of rivaroxaban and ritonavir. Co-administration of ritonavir and rivaroxaban may lead to risk of increased bleeding.”
Check it at the source: the ritonavir FDA label on DailyMed (effective July 23, 2026, AbbVie Inc.); the rivaroxaban FDA label on DailyMed (effective September 10, 2026, Janssen Pharmaceuticals, Inc.).
What does the ritonavir label say about rivaroxaban?
Ritonavir label, drug interactionsConcomitant Drug Class/Drug Name: Anticoagulant: rivaroxaban; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ rivaroxaban; Clinical Comment: Avoid concomitant use of rivaroxaban and ritonavir. Co-administration of ritonavir and rivaroxaban may lead to risk of increased bleeding.
Source: FDA drug label (Norvir), AbbVie Inc., effective July 23, 2026 (SPL set 2849298e-de6e-47bb-8194-56e075b33fc3), via openFDA; the full label on DailyMed
What does the rivaroxaban label say about ritonavir?
Rivaroxaban label, drug interactionsDrugs that Inhibit Cytochrome P450 3A Enzymes and Drug Transport Systems Interaction with Combined P-gp and Strong CYP3A Inhibitors Avoid concomitant administration of XARELTO with known combined P-gp and strong CYP3A inhibitors (e.g., ketoconazole and ritonavir) [see Warnings and Precautions (5.6) and Clinical Pharmacology (12.3) ].
Source: FDA drug label (Xarelto), Janssen Pharmaceuticals, Inc., effective September 10, 2026 (SPL set 10db92f9-2300-4a80-836b-673e1ae91610), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ritonavir | Rivaroxaban | |
|---|---|---|
| Labeled for | HIV | Atrial fibrillation, Heart attack and coronary artery disease, Blood clots (DVT and PE), Stroke prevention |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.607 per tablet 100 mg tablet | $0.650 per tablet 2.5 mg tablet |
| Shortage now | A presentation being discontinued | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once