What the FDA labels say about taking them together
Ritonavir and voriconazole
Ritonavir's FDA label of July 23, 2026 names voriconazole in its contraindications section, and voriconazole's label names ritonavir too. The voriconazole label: “Contraindicated”
Check it at the source: the ritonavir FDA label on DailyMed (effective July 23, 2026, AbbVie Inc.); the voriconazole FDA label on DailyMed (effective February 26, 2026, Roerig).
What does the ritonavir label say about voriconazole?
Ritonavir label, contraindicationsNORVIR is contraindicated with drugs that are highly dependent on CYP3A for clearance and for which elevated plasma concentrations are associated with serious and/or life-threatening reactions [see Drug Interactions ( 7.1 ) and Clinical Pharmacology ( 12.3 )]. ○ Alpha 1- Adrenoreceptor Antagonist: alfuzosin ○ Antianginal: ranolazine ○ Antiarrhythmics: amiodarone, dronedarone, flecainide, propafenone, quinidine ○ Antifungal: voriconazole ○ Anti-gout: colchicine ○ Antipsychotics: lurasidone, pimozide ○ Ergot Derivatives: dihydroergotamine, ergotamine, methylergonovine ○ GI Motility Agent: cisapride ○ HMG-CoA Reductase Inhibitors: lovastatin, simvastatin ○ Microsomal triglyceride transfer …
Ritonavir label, drug interactionsConcomitant Drug Class/Drug Name: Antifungals: ketoconazole itraconazole voriconazole; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ ketoconazole ↑ itraconazole ↓ voriconazole; Clinical Comment: High doses of ketoconazole or itraconazole (greater than 200 mg per day) are not recommended. Co-administration of voriconazole and ritonavir doses of 400 mg every 12 hours or greater is contraindicated due to the potential for loss of antifungal response [see Contraindications () ]. Co-administration of voriconazole and ritonavir 100 mg should be avoided, unless an assessment of the benefit/risk to the patient justifies the use of voriconazole.
Source: FDA drug label (Norvir), AbbVie Inc., effective July 23, 2026 (SPL set 2849298e-de6e-47bb-8194-56e075b33fc3), via openFDA; the full label on DailyMed
What does the voriconazole label say about ritonavir?
Voriconazole label, contraindicationsRitonavir Concomitant use with high-dose ritonavir (400 mg every 12 hours) is contraindicated.
Voriconazole label, drug interactionsDrug/Drug Class (Mechanism of Interaction by the Drug): High-dose Ritonavir (400 mg every 12 hours) (CYP450 Induction); Voriconazole Plasma Exposure (C max and AUC τ after 200 mg every 12 hours): Significantly Reduced; Prevention or Management Recommendations: Contraindicated
Voriconazole label (Xellia Pharmaceuticals USA LLC, January 11, 2023), contraindicationsCoadministration of Voriconazole for injection with high-dose ritonavir (400 mg every 12 hours) is contraindicated because ritonavir (400 mg every 12 hours) significantly decreases plasma voriconazole concentrations.
Voriconazole label (Xellia Pharmaceuticals USA LLC, January 11, 2023), drug interactionsDrug/Drug Class (Mechanism of Interaction by the Drug): High-dose Ritonavir (400 mg every 12 hours) (CYP450 Induction); Voriconazole Plasma Exposure (C max and AUC τ after 200 mg every 12 hours): Significantly Reduced; Recommendations for Voriconazole Dosage Adjustment/Comments: Contraindicated
Source: FDA drug label (Voriconazole, NDA208562), Xellia Pharmaceuticals USA LLC, effective January 11, 2023 (SPL set 9ec6eda2-2f15-423b-9ec6-819379a426e1), via openFDA
Source: FDA drug label (VFEND), NDA021630 (Pf Prism Cv), as published by Roerig, effective February 26, 2026 (SPL set ce3ef5cf-3087-4d92-9d94-9eb8287228db), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ritonavir | Voriconazole | |
|---|---|---|
| Labeled for | HIV | Fungal infections |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.607 per tablet 100 mg tablet | $1.88 per tablet 200 mg tablet |
| Shortage now | A presentation being discontinued | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once