What the FDA labels say about taking them together
Drospirenone/estetrol and ritonavir
Drospirenone/estetrol's FDA label of May 11, 2023 names ritonavir in its contraindications section; the ritonavir label PlainMeds reads does not name drospirenone/estetrol. The drospirenone/estetrol label: “Elevations with Concomitant Hepatitis C Treatment CHCs, such as NEXTSTELLIS, are contraindicated for use with Hepatitis C drug combinations containing ombitasvir/paritaprevir/ritonavir.”
Check it at the source: the drospirenone/estetrol FDA label on DailyMed (effective May 11, 2023); the ritonavir FDA label on DailyMed (effective July 23, 2026, AbbVie Inc.).
What does the drospirenone/estetrol label say about ritonavir?
Drospirenone/estetrol label, contraindications… Warnings and Precautions (5.5) ] Hepatic adenoma, hepatocellular carcinoma, acute hepatitis, or severe (decompensated) cirrhosis [see Warnings and Precautions (5.6) ] Use of hepatitis C drug combinations containing ombitasvir/paritaprevir/ritonavir, with or without dasabuvir, due to the potential for ALT elevations [see Warnings and Precautions (5.7) ] Abnormal uterine bleeding that has an undiagnosed etiology [see Warnings and Precautions (5.5) ] Renal Impairment [see Warnings and Precautions (5.2) ] Adrenal insufficiency [see Warnings and Precautions (5.2) ] A high risk of arterial or venous thrombotic diseases ( 4 ) Breast cancer or history of breast cancer ( 4 ) Hepatic adenoma …
Drospirenone/estetrol label, warnings and precautionsElevations with Concomitant Hepatitis C Treatment CHCs, such as NEXTSTELLIS, are contraindicated for use with Hepatitis C drug combinations containing ombitasvir/paritaprevir/ritonavir (with or without dasabuvir) [see Contraindications (4) ].
Source: FDA drug label (Nextstellis), Mayne Pharma, effective May 11, 2023 (SPL set c5270073-d083-4109-ae4b-156986175e0a), via openFDA; the full label on DailyMed
What does the ritonavir label say about drospirenone/estetrol?
Ritonavir's label (effective July 23, 2026) does not name drospirenone/estetrol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Norvir), AbbVie Inc., effective July 23, 2026 (SPL set 2849298e-de6e-47bb-8194-56e075b33fc3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Drospirenone/estetrol | Ritonavir | |
|---|---|---|
| Labeled for | Birth control | HIV |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $7.67 per tablet 3-14.2 mg tablet | $0.607 per tablet 100 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once