What the FDA labels say about taking them together
Ritonavir and zolpidem
Ritonavir's FDA label of July 23, 2026 names zolpidem in its drug interactions section; the zolpidem labels PlainMeds reads (4) do not name ritonavir. The ritonavir label: “A dose decrease may be needed for these drugs when co-administered with ritonavir.”
Check it at the source: the ritonavir FDA label on DailyMed (effective July 23, 2026, AbbVie Inc.); the zolpidem FDA label on DailyMed (effective August 15, 2022, Viatris Specialty LLC).
What does the ritonavir label say about zolpidem?
Ritonavir label, drug interactionsConcomitant Drug Class/Drug Name: Sedative/hypnotics: buspirone, clorazepate, diazepam, estazolam, flurazepam, zolpidem; Effect on Concentration of Ritonavir or Concomitant Drug: ↑ sedative/hypnotics; Clinical Comment: A dose decrease may be needed for these drugs when co-administered with ritonavir.
Source: FDA drug label (Norvir), AbbVie Inc., effective July 23, 2026 (SPL set 2849298e-de6e-47bb-8194-56e075b33fc3), via openFDA; the full label on DailyMed
What does the zolpidem label say about ritonavir?
Zolpidem's label (effective August 15, 2022) and its 3 other brand-application labels do not name ritonavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Edluar), Viatris Specialty LLC, effective August 15, 2022 (SPL set a32884d0-85b5-11de-8a39-0800200c9a66), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ritonavir | Zolpidem | |
|---|---|---|
| Labeled for | HIV | Insomnia |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.607 per tablet 100 mg tablet | $0.0344 per tablet 5 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once