What the FDA labels say about taking them together
Cyclosporine and ritonavir
Cyclosporine's FDA label of August 10, 2026 names ritonavir in its drug interactions section, and ritonavir's label names cyclosporine too. The ritonavir label: “Therapeutic concentration monitoring is recommended for immunosuppressant agents when co-administered with ritonavir.”
Check it at the source: the cyclosporine FDA label on DailyMed (effective August 10, 2026, Novartis Pharmaceuticals Corporation); the ritonavir FDA label on DailyMed (effective July 23, 2026, AbbVie Inc.).
What does the cyclosporine label say about ritonavir?
Cyclosporine label, drug interactionsDrugs That Increase Cyclosporine Concentrations Calcium Channel Blockers Antifungals Antibiotics Glucocorticoids Other Drugs diltiazem fluconazole azithromycin methylprednisolone Allopurinol nicardipine itraconazole clarithromycin Amiodarone verapamil ketoconazole erythromycin Bromocriptine voriconazole quinupristin/ dalfopristin colchicine danazol imatinib metoclopramide nefazodone oral contraceptives HIV Protease Inhibitors The HIV protease inhibitors (e.g., indinavir, nelfinavir, ritonavir, and saquinavir) are known to inhibit cytochrome P-450 3A and thus could potentially increase the concentrations of cyclosporine, however no formal studies of the interaction are available.
Source: FDA drug label (Neoral), Novartis Pharmaceuticals Corporation, effective August 10, 2026 (SPL set 94461af3-11f1-4670-95d4-2965b9538ae3), via openFDA; the full label on DailyMed
What does the ritonavir label say about cyclosporine?
Ritonavir label, drug interactionsConcomitant Drug Class/Drug Name: Immunosuppressants: cyclosporine, tacrolimus, sirolimus (rapamycin); Effect on Concentration of Ritonavir or Concomitant Drug: ↑ immunosuppressants; Clinical Comment: Therapeutic concentration monitoring is recommended for immunosuppressant agents when co-administered with ritonavir.
Source: FDA drug label (Norvir), AbbVie Inc., effective July 23, 2026 (SPL set 2849298e-de6e-47bb-8194-56e075b33fc3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cyclosporine | Ritonavir | |
|---|---|---|
| Labeled for | Organ transplant rejection, Rheumatoid arthritis | HIV |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $1.04 per unit 0.05% eye emulsion | $0.607 per tablet 100 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once