Side effects across medicines
Medicines whose labels list itching
1,205 medicines have an FDA label that names itching (pruritus) in its boxed warning, warnings, adverse reactions, trial table, patient leaflet or Drug Facts “stop use” warning (of the labels PlainMeds reads: each medicine's quoted label and up to eight more, by route and wording). Among them, the most FAERS reports of itching name dupilumab (58,692), adalimumab (14,769) and etanercept (12,555), through July 30, 2026. A label lists what its studies and reports found, and a report does not show that a medicine caused the event.
Check it at the source: the FDA FAERS public dashboard; FDA labels on DailyMed.
Which medicines' labels list itching?
Ordered by where the label names it, the boxed warning first, then by FAERS reports. The first 150 of the 1,205 are below; every other one is on its medicine record. A medicine whose own indications name it, because it treats it, is not counted.
| Medicine | Where a label names it | FAERS reports of itching |
|---|---|---|
| Tacrolimus | precautions (topical label) | 1,966 |
| Buprenorphine | warnings and precautions (subcutaneous label) | 1,199 |
| Aprepitant | warnings and precautions (intravenous label) | 1,077 |
| Levofloxacin | warnings and precautions (ophthalmic label) | 1,075 |
| Oxybutynin | warnings (transdermal label) | 1,006 |
| Ipratropium | warnings and precautions (respiratory (inhalation) label) | 895 |
| Moxifloxacin | warnings and precautions (ophthalmic label) | 646 |
| Insulin human | warnings and precautions (subcutaneous label) | 482 |
| Fluocinolone | precautions | 216 |
| Granisetron | warnings and precautions (transdermal label) | 176 |
| Ofloxacin | precautions (oral label) | 154 |
| Ascorbic acid, peg 3350 and 4 other ingredients | warnings and precautions | none in the top 1,000 |
| Ascorbic acid, polyethylene glycol 3350 and 4 other ingredients | warnings and precautions | none in the top 1,000 |
| Avutometinib and defactinib | warnings and precautions | none in the top 1,000 |
| Azelaic acid | precautions (cutaneous label) | none in the top 1,000 |
| Chlorzoxazone | precautions | none in the top 1,000 |
| Ciclopirox | precautions | none in the top 1,000 |
| Daratumumab | warnings and precautions | none in the top 1,000 |
| Dexamethasone and neomycin and polymyxin b | warnings (topical label) | none in the top 1,000 |
| Dextroamphetamine | warnings and precautions (transdermal label) | none in the top 1,000 |
| Diatrizoate | precautions | none in the top 1,000 |
| Ganciclovir | warnings and precautions (ophthalmic label) | none in the top 1,000 |
| Hyaluronidase and ocrelizumab | warnings and precautions | none in the top 1,000 |
| Hyaluronidase and rituximab | warnings and precautions | none in the top 1,000 |
| Hydroxyprogesterone caproate | precautions | none in the top 1,000 |
| Indium in -111 pentetreotide | warnings | none in the top 1,000 |
| Magnesium sulfate, polyethylene glycol 3350 and 3 other ingredients | warnings and precautions | none in the top 1,000 |
| Mesna | warnings and precautions (oral label) | none in the top 1,000 |
| Obiltoxaximab | warnings and precautions | none in the top 1,000 |
| Oxiconazole | precautions | none in the top 1,000 |
| Palovarotene | warnings and precautions | none in the top 1,000 |
| Propylthiouracil | precautions | none in the top 1,000 |
| Raxibacumab | warnings and precautions | none in the top 1,000 |
| Succimer | warnings and precautions (intravenous label) | none in the top 1,000 |
| Tazarotene | warnings and precautions (topical label) | none in the top 1,000 |
| Tioconazole | warnings (topical label) | none in the top 1,000 |
| Ubrogepant | warnings and precautions | none in the top 1,000 |
| Dupilumab | adverse reactions | 58,692 |
| Adalimumab | adverse reactions | 14,769 |
| Etanercept | adverse reactions | 12,555 |
| Methotrexate | adverse reactions | 12,368 |
| Adapalene | adverse reactions | 11,881 |
| Omeprazole | adverse reactions | 10,160 |
| Levothyroxine | adverse reactions | 9,468 |
| Pantoprazole | adverse reactions | 9,000 |
| Folic acid | adverse reactions | 8,271 |
| Lisinopril | adverse reactions | 7,988 |
| Lenalidomide | adverse reactions | 7,423 |
| Infliximab | adverse reactions | 7,105 |
| Furosemide | adverse reactions (intravenous label) | 7,098 |
| Tocilizumab | adverse reactions | 6,821 |
| Omalizumab | adverse reactions | 6,360 |
| Rituximab | adverse reactions | 6,327 |
| Leflunomide | adverse reactions | 6,271 |
| Diclofenac | adverse reactions (oral label) | 6,209 |
| Pregabalin | adverse reactions | 6,160 |
| Amlodipine | adverse reactions | 6,105 |
| Abatacept | adverse reactions | 6,009 |
| Simvastatin | adverse reactions | 5,933 |
| Metoprolol | adverse reactions | 5,833 |
| Oxycodone | adverse reactions | 5,791 |
| Losartan | adverse reactions | 5,180 |
| Hydroxychloroquine | adverse reactions | 5,160 |
| Dimethyl fumarate | adverse reactions | 5,067 |
| Alendronate | adverse reactions | 5,050 |
| Tofacitinib | adverse reactions | 5,019 |
| Celecoxib | adverse reactions | 4,801 |
| Sulfasalazine | adverse reactions | 4,769 |
| Ribavirin | adverse reactions | 4,643 |
| Esomeprazole | adverse reactions (intravenous label) | 4,629 |
| Montelukast | adverse reactions | 4,526 |
| Peginterferon alfa 2a | adverse reactions | 4,225 |
| Clopidogrel | adverse reactions | 4,147 |
| Alprazolam | adverse reactions | 3,886 |
| Fluticasone | adverse reactions (respiratory (inhalation) label) | 3,570 |
| Allopurinol | adverse reactions | 3,554 |
| Ustekinumab | adverse reactions | 3,526 |
| Ramipril | adverse reactions | 3,488 |
| Desoximetasone | adverse reactions | 3,431 |
| Clonazepam | adverse reactions | 3,138 |
| Sulfamethoxazole and trimethoprim | adverse reactions | 3,049 |
| Lamotrigine | adverse reactions | 3,037 |
| Bisoprolol | adverse reactions | 3,007 |
| Insulin glargine | adverse reactions | 2,945 |
| Amoxicillin | adverse reactions | 2,884 |
| Citalopram | adverse reactions | 2,847 |
| Carvedilol | adverse reactions | 2,846 |
| Risankizumab | adverse reactions | 2,698 |
| Cyclosporine | adverse reactions | 2,689 |
| Prednisolone | adverse reactions (ophthalmic label) | 2,665 |
| Sertraline | adverse reactions | 2,649 |
| Triamcinolone | adverse reactions | 2,630 |
| Zolpidem | adverse reactions | 2,550 |
| Venlafaxine | adverse reactions | 2,533 |
| Estradiol | adverse reactions | 2,516 |
| Rivaroxaban | adverse reactions | 2,467 |
| Ondansetron | adverse reactions | 2,420 |
| Ciprofloxacin | adverse reactions | 2,377 |
| Adalimumab-aaty | adverse reactions | 2,343 |
| Bupropion | adverse reactions | 2,328 |
| Adalimumab-fkjp | adverse reactions | 2,313 |
| Rosuvastatin | adverse reactions | 2,259 |
| Sodium chloride | adverse reactions | 2,206 |
| Acyclovir | adverse reactions | 2,163 |
| Tiotropium | adverse reactions | 2,140 |
| Budesonide and formoterol | adverse reactions | 2,025 |
| Natalizumab | adverse reactions | 1,945 |
| Baclofen | adverse reactions | 1,865 |
| Diazepam | adverse reactions (rectal label) | 1,864 |
| Warfarin | adverse reactions | 1,842 |
| Dextrose and potassium chloride | adverse reactions | 1,837 |
| Carboplatin | adverse reactions | 1,826 |
| Ruxolitinib | adverse reactions (topical label) | 1,808 |
| Nivolumab | adverse reactions | 1,782 |
| Pembrolizumab | adverse reactions | 1,754 |
| Palbociclib | adverse reactions | 1,716 |
| Sarilumab | adverse reactions | 1,708 |
| Morphine | adverse reactions | 1,679 |
| Letrozole | adverse reactions | 1,677 |
| Sacubitril and valsartan | adverse reactions | 1,643 |
| Topiramate | adverse reactions | 1,591 |
| Duloxetine | adverse reactions | 1,560 |
| Metronidazole | adverse reactions | 1,541 |
| Pomalidomide | adverse reactions | 1,500 |
| Tramadol | adverse reactions | 1,409 |
| Valacyclovir | adverse reactions | 1,407 |
| Insulin lispro | adverse reactions | 1,365 |
| Ribociclib | adverse reactions | 1,365 |
| Azithromycin | adverse reactions | 1,364 |
| Vedolizumab | adverse reactions | 1,361 |
| Mesalamine | adverse reactions (rectal label) | 1,356 |
| Treprostinil | adverse reactions | 1,353 |
| Mirtazapine | adverse reactions | 1,347 |
| Diltiazem | adverse reactions | 1,345 |
| Sitagliptin | adverse reactions | 1,343 |
| Fluconazole | adverse reactions | 1,317 |
| Vancomycin | adverse reactions | 1,317 |
| Budesonide | adverse reactions | 1,294 |
| Mometasone | adverse reactions (topical label) | 1,286 |
| Sildenafil | adverse reactions | 1,279 |
| Cyclobenzaprine | adverse reactions | 1,204 |
| Cabozantinib | adverse reactions | 1,203 |
| Oxaliplatin | adverse reactions | 1,203 |
| Glatiramer | adverse reactions | 1,191 |
| Cyanocobalamin | adverse reactions | 1,163 |
| Nilotinib | adverse reactions | 1,132 |
| Finasteride | adverse reactions | 1,121 |
| Insulin aspart | adverse reactions | 1,118 |
| Candesartan | adverse reactions | 1,109 |
| Tadalafil | adverse reactions | 1,108 |
Source: FDA drug labels via openFDA, read October 8, 2026; FAERS via openFDA, reports through July 30, 2026
Which of them have the most itching reports in FAERS?
Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026; MedDRA preferred term “Pruritus”
What next?
- Side effects across medicines
- every reaction on PlainMeds
- Report a side effect to the FDA
- MedWatch