Side effects across medicines
Medicines whose labels list abdominal distension
118 medicines have an FDA label that names abdominal distension in its boxed warning, warnings, adverse reactions, trial table, patient leaflet or Drug Facts “stop use” warning (of the labels PlainMeds reads: each medicine's quoted label and up to eight more, by route and wording). Among them, the most FAERS reports of abdominal distension name pregabalin (1,805), tirzepatide (1,748) and semaglutide (1,691), through July 30, 2026. A label lists what its studies and reports found, and a report does not show that a medicine caused the event.
Check it at the source: the FDA FAERS public dashboard; FDA labels on DailyMed.
Which medicines' labels list abdominal distension?
Ordered by where the label names it, the boxed warning first, then by FAERS reports. A medicine whose own indications name it, because it treats it, is not counted.
| Medicine | Where a label names it | FAERS reports of abdominal distension |
|---|---|---|
| Menotropins | warnings and precautions | 182 |
| Doxapram | precautions | none in the top 1,000 |
| Pregabalin | adverse reactions | 1,805 |
| Tirzepatide | adverse reactions | 1,748 |
| Semaglutide | adverse reactions (oral label) | 1,691 |
| Exenatide | adverse reactions | 1,311 |
| Dulaglutide | adverse reactions | 1,171 |
| Linaclotide | adverse reactions | 1,170 |
| Octreotide | adverse reactions | 1,142 |
| Mesalamine | adverse reactions (rectal label) | 985 |
| Riociguat | adverse reactions | 824 |
| Teduglutide | adverse reactions | 724 |
| Capecitabine | adverse reactions | 671 |
| Budesonide | adverse reactions (oral label) | 669 |
| Calcium chloride, dextrose, magnesium chloride, sodium chloride and sodium lactate | adverse reactions (intraperitoneal label) | 613 |
| Abaloparatide | adverse reactions | 526 |
| Mirabegron | adverse reactions | 512 |
| Olanzapine | adverse reactions | 489 |
| Magnesium sulfate and potassium sulfate and sodium sulfate | adverse reactions | 393 |
| Bortezomib | adverse reactions | 375 |
| Pirfenidone | adverse reactions | 349 |
| Progesterone | adverse reactions | 322 |
| Clarithromycin | adverse reactions | 280 |
| Carbidopa and levodopa | adverse reactions (enteral label) | 254 |
| Dicyclomine | adverse reactions | 248 |
| Nilotinib | adverse reactions | 246 |
| Copper | adverse reactions | 240 |
| Medroxyprogesterone | adverse reactions (subcutaneous label) | 237 |
| Lubiprostone | adverse reactions | 196 |
| Mycophenolic acid | adverse reactions | 191 |
| Elexacaftor and ivacaftor and tezacaftor | adverse reactions | 162 |
| Vonoprazan | adverse reactions | 152 |
| Lomitapide | adverse reactions | 125 |
| Olaparib | adverse reactions | 124 |
| Lopinavir and ritonavir | adverse reactions | 120 |
| Ascorbic acid, polyethylene glycol 3350 and 4 other ingredients | adverse reactions | 117 |
| Plecanatide | adverse reactions | 117 |
| Magnesium sulfate and potassium chloride and sodium sulfate | adverse reactions | 94 |
| Aprepitant | adverse reactions (intravenous label) | 91 |
| Amikacin | adverse reactions (respiratory (inhalation) label) | 84 |
| Prucalopride | adverse reactions | 81 |
| Vilazodone | adverse reactions | 80 |
| Donor human stool spores | adverse reactions | 74 |
| Darunavir | adverse reactions | 68 |
| Neratinib | adverse reactions | 67 |
| Sevelamer | adverse reactions (parenteral label) | 67 |
| Follitropin | adverse reactions | 62 |
| Ethinyl estradiol and norgestimate | adverse reactions | 58 |
| Acetaminophen and benzhydrocodone | adverse reactions | none in the top 1,000 |
| Alanine, arginine and 22 other ingredients | adverse reactions | none in the top 1,000 |
| Amisulpride | adverse reactions | none in the top 1,000 |
| Ampicillin and sulbactam | adverse reactions | none in the top 1,000 |
| Anidulafungin | adverse reactions | none in the top 1,000 |
| Arsenic trioxide | adverse reactions | none in the top 1,000 |
| Ascorbic acid, peg 3350 and 4 other ingredients | adverse reactions | none in the top 1,000 |
| Asparaginase | adverse reactions | none in the top 1,000 |
| Bendamustine | adverse reactions | none in the top 1,000 |
| Brigatinib | adverse reactions | none in the top 1,000 |
| Cabotegravir | adverse reactions (oral label) | none in the top 1,000 |
| Caspofungin | adverse reactions | none in the top 1,000 |
| Ceftolozane and tazobactam | adverse reactions | none in the top 1,000 |
| Chloramphenicol | adverse reactions | none in the top 1,000 |
| Cipaglucosidase alfa | adverse reactions | none in the top 1,000 |
| Colesevelam | adverse reactions | none in the top 1,000 |
| Crofelemer | adverse reactions | none in the top 1,000 |
| Cytarabine and daunorubicin | adverse reactions | none in the top 1,000 |
| Daptomycin | adverse reactions | none in the top 1,000 |
| Dasatinib | adverse reactions | none in the top 1,000 |
| Decitabine | adverse reactions | none in the top 1,000 |
| Donor human stool | adverse reactions | none in the top 1,000 |
| Doravirine and islatravir | adverse reactions | none in the top 1,000 |
| Doxylamine and pyridoxine | adverse reactions | none in the top 1,000 |
| Elagolix and estradiol and norethisterone | adverse reactions | none in the top 1,000 |
| Esomeprazole and naproxen | adverse reactions | none in the top 1,000 |
| Estradiol and levonorgestrel | adverse reactions | none in the top 1,000 |
| Ethinyl estradiol and levonorgestrel | adverse reactions | none in the top 1,000 |
| Ethinyl estradiol and norelgestromin | adverse reactions | none in the top 1,000 |
| Etodolac | adverse reactions | none in the top 1,000 |
| Etravirine | adverse reactions | none in the top 1,000 |
| Ferric maltol | adverse reactions | none in the top 1,000 |
| Fexinidazole | adverse reactions | none in the top 1,000 |
| Fidaxomicin | adverse reactions | none in the top 1,000 |
| Fluoxetine and olanzapine | adverse reactions | none in the top 1,000 |
| Gepotidacin | adverse reactions | none in the top 1,000 |
| Human botulinum neurotoxin a b immune globulin | adverse reactions | none in the top 1,000 |
| Inotuzumab ozogamicin | adverse reactions | none in the top 1,000 |
| Insulin degludec and liraglutide | adverse reactions | none in the top 1,000 |
| Insulin glargine and lixisenatide | adverse reactions | none in the top 1,000 |
| Iomeprol | adverse reactions | none in the top 1,000 |
| Isavuconazonium | adverse reactions | none in the top 1,000 |
| Levoketoconazole | adverse reactions | none in the top 1,000 |
| Linerixibat | adverse reactions | none in the top 1,000 |
| Magnesium sulfate, polyethylene glycol 3350 and 3 other ingredients | adverse reactions | none in the top 1,000 |
| Maralixibat | adverse reactions | none in the top 1,000 |
| Micafungin | adverse reactions | none in the top 1,000 |
| Miglustat | adverse reactions | none in the top 1,000 |
| Milnacipran | adverse reactions | none in the top 1,000 |
| Mirvetuximab soravtansine | adverse reactions | none in the top 1,000 |
| Nelarabine | adverse reactions | none in the top 1,000 |
| Orforglipron | adverse reactions | none in the top 1,000 |
| Pasireotide | adverse reactions | none in the top 1,000 |
| Pegcetacoplan | adverse reactions | none in the top 1,000 |
| Penpulimab | adverse reactions | none in the top 1,000 |
| Ponatinib | adverse reactions | none in the top 1,000 |
| Probenecid and sulopenem etzadroxil | adverse reactions | none in the top 1,000 |
| Seladelpar lysine | adverse reactions | none in the top 1,000 |
| Sodium benzoate and sodium phenylacetate | adverse reactions | none in the top 1,000 |
| Somapacitan | adverse reactions | none in the top 1,000 |
| Tecovirimat | adverse reactions | none in the top 1,000 |
| Tiopronin | adverse reactions | none in the top 1,000 |
| Trastuzumab deruxtecan | adverse reactions | none in the top 1,000 |
| Treosulfan | adverse reactions | none in the top 1,000 |
| Triheptanoin | adverse reactions | none in the top 1,000 |
| Trospium | adverse reactions | none in the top 1,000 |
| Vigabatrin | adverse reactions | none in the top 1,000 |
| Zenocutuzumab | adverse reactions | none in the top 1,000 |
| Zoliflodacin | adverse reactions | none in the top 1,000 |
| Tenapanor | trial table | 234 |
Source: FDA drug labels via openFDA, read October 8, 2026; FAERS via openFDA, reports through July 30, 2026
Which of them have the most abdominal distension reports in FAERS?
Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026; MedDRA preferred term “Abdominal Distension”
What next?
- Side effects across medicines
- every reaction on PlainMeds
- Report a side effect to the FDA
- MedWatch