Side effects across medicines
Medicines whose labels list alanine aminotransferase increased
157 medicines have an FDA label that names alanine aminotransferase increased in its boxed warning, warnings, adverse reactions, trial table, patient leaflet or Drug Facts “stop use” warning (of the labels PlainMeds reads: each medicine's quoted label and up to eight more, by route and wording). Among them, the most FAERS reports of alanine aminotransferase increased name rituximab (1,886), pregabalin (1,031) and olanzapine (963), through July 30, 2026. A label lists what its studies and reports found, and a report does not show that a medicine caused the event.
Check it at the source: the FDA FAERS public dashboard; FDA labels on DailyMed.
Which medicines' labels list alanine aminotransferase increased?
Ordered by where the label names it, the boxed warning first, then by FAERS reports. The first 150 of the 157 are below; every other one is on its medicine record. A medicine whose own indications name it, because it treats it, is not counted.
| Medicine | Where a label names it | FAERS reports of alanine aminotransferase increased |
|---|---|---|
| Rituximab | adverse reactions | 1,886 |
| Pregabalin | adverse reactions | 1,031 |
| Olanzapine | adverse reactions (intramuscular label) | 963 |
| Ribociclib | adverse reactions | 935 |
| Risperidone | adverse reactions | 571 |
| Lenalidomide | adverse reactions | 443 |
| Peginterferon alfa 2a | adverse reactions | 339 |
| Fulvestrant | adverse reactions | 335 |
| Palbociclib | adverse reactions | 312 |
| Piperacillin and tazobactam | adverse reactions | 286 |
| Pegaspargase | adverse reactions | 274 |
| Abiraterone | adverse reactions | 269 |
| Lopinavir and ritonavir | adverse reactions | 256 |
| Lenvatinib | adverse reactions | 229 |
| Nilotinib | adverse reactions | 226 |
| Fezolinetant | adverse reactions | 192 |
| Moxifloxacin | adverse reactions | 183 |
| Trastuzumab emtansine | adverse reactions | 177 |
| Lapatinib ditosylate | adverse reactions | 176 |
| Elexacaftor and ivacaftor and tezacaftor | adverse reactions | 172 |
| Gemtuzumab ozogamicin | adverse reactions | 163 |
| Apixaban | adverse reactions | 155 |
| Golimumab | adverse reactions | 154 |
| Itraconazole | adverse reactions | 152 |
| Lomitapide | adverse reactions | 147 |
| Brentuximab vedotin | adverse reactions | 146 |
| Polatuzumab vedotin | adverse reactions | 146 |
| Gefitinib | adverse reactions | 136 |
| Micafungin | adverse reactions | 131 |
| Aprepitant | adverse reactions | 128 |
| Blinatumomab | adverse reactions | 123 |
| Posaconazole | adverse reactions (intravenous label) | 123 |
| Durvalumab | adverse reactions | 122 |
| Tramadol | adverse reactions | 122 |
| Nintedanib | adverse reactions | 115 |
| Axitinib | adverse reactions | 105 |
| Eltrombopag | adverse reactions | 105 |
| Ganciclovir | adverse reactions | 92 |
| Encorafenib | adverse reactions | 90 |
| Valganciclovir | adverse reactions | 89 |
| Baricitinib | adverse reactions | 87 |
| Panitumumab | adverse reactions | 87 |
| Caspofungin | adverse reactions | 84 |
| Diclofenac and misoprostol | adverse reactions | 83 |
| Pomalidomide | adverse reactions | 83 |
| Bosutinib | adverse reactions | 81 |
| Sotorasib | adverse reactions | 79 |
| Tucatinib | adverse reactions | 74 |
| Paliperidone | adverse reactions | 70 |
| Sarilumab | adverse reactions | 65 |
| Dinutuximab | adverse reactions | 61 |
| Interferon beta 1b | adverse reactions | 61 |
| Inotuzumab ozogamicin | adverse reactions | 54 |
| Ramucirumab | adverse reactions | 53 |
| Siponimod | adverse reactions | 50 |
| Tapentadol | adverse reactions | 47 |
| Omadacycline | adverse reactions | 46 |
| Relugolix | adverse reactions | 46 |
| Daptomycin | adverse reactions | 44 |
| Progesterone | adverse reactions | 44 |
| Tremelimumab | adverse reactions | 44 |
| Buprenorphine | adverse reactions (transdermal label) | 39 |
| Peginterferon beta 1a | adverse reactions | 35 |
| Deferiprone | adverse reactions | 33 |
| Dexmedetomidine | adverse reactions | 31 |
| Abemaciclib | adverse reactions | none in the top 1,000 |
| Abiraterone and niraparib | adverse reactions | none in the top 1,000 |
| Adagrasib | adverse reactions | none in the top 1,000 |
| Alanine, arginine and 22 other ingredients | adverse reactions | none in the top 1,000 |
| Anidulafungin | adverse reactions | none in the top 1,000 |
| Artemether and lumefantrine | adverse reactions | none in the top 1,000 |
| Asenapine | adverse reactions (transdermal label) | none in the top 1,000 |
| Asparaginase | adverse reactions | none in the top 1,000 |
| Avanafil | adverse reactions | none in the top 1,000 |
| Avelumab | adverse reactions | none in the top 1,000 |
| Avibactam and aztreonam | adverse reactions | none in the top 1,000 |
| Belantamab mafodotin | adverse reactions | none in the top 1,000 |
| Belumosudil | adverse reactions | none in the top 1,000 |
| Bismuth subcitrate and metronidazole and tetracycline | adverse reactions | none in the top 1,000 |
| Calaspargase | adverse reactions | none in the top 1,000 |
| Camizestrant | adverse reactions | none in the top 1,000 |
| Carglumic acid | adverse reactions | none in the top 1,000 |
| Cariprazine | adverse reactions | none in the top 1,000 |
| Cedazuridine and decitabine | adverse reactions | none in the top 1,000 |
| Cefepime and zidebactam | adverse reactions | none in the top 1,000 |
| Cefiderocol | adverse reactions | none in the top 1,000 |
| Ceftaroline | adverse reactions | none in the top 1,000 |
| Ceftobiprole medocaril | adverse reactions | none in the top 1,000 |
| Cemiplimab | adverse reactions | none in the top 1,000 |
| Cenobamate | adverse reactions | none in the top 1,000 |
| Cilastatin and imipenem and relebactam | adverse reactions | none in the top 1,000 |
| Danicopan | adverse reactions | none in the top 1,000 |
| Daratumumab and hyaluronidase | adverse reactions | none in the top 1,000 |
| Daraxonrasib | adverse reactions | none in the top 1,000 |
| Denileukin diftitox | adverse reactions | none in the top 1,000 |
| Desflurane | adverse reactions | none in the top 1,000 |
| Dordaviprone | adverse reactions | none in the top 1,000 |
| Doxecitine and doxribtimine | adverse reactions | none in the top 1,000 |
| Duvelisib | adverse reactions | none in the top 1,000 |
| Elacestrant | adverse reactions | none in the top 1,000 |
| Ensartinib | adverse reactions | none in the top 1,000 |
| Epcoritamab | adverse reactions | none in the top 1,000 |
| Etranacogene dezaparvovec | adverse reactions | none in the top 1,000 |
| Famotidine and ibuprofen | adverse reactions | none in the top 1,000 |
| Fedratinib | adverse reactions | none in the top 1,000 |
| Ferric carboxymaltose | adverse reactions | none in the top 1,000 |
| Fidaxomicin | adverse reactions | none in the top 1,000 |
| Fitusiran | adverse reactions | none in the top 1,000 |
| Fluoxetine and olanzapine | adverse reactions | none in the top 1,000 |
| Fruquintinib | adverse reactions | none in the top 1,000 |
| Gadoteridol | adverse reactions | none in the top 1,000 |
| Gilteritinib | adverse reactions | none in the top 1,000 |
| Iloperidone | adverse reactions | none in the top 1,000 |
| Imlunestrant | adverse reactions | none in the top 1,000 |
| Isatuximab | adverse reactions (subcutaneous label) | none in the top 1,000 |
| Isoflurane | adverse reactions | none in the top 1,000 |
| Ivosidenib | adverse reactions | none in the top 1,000 |
| Meropenem and vaborbactam | adverse reactions | none in the top 1,000 |
| Midostaurin | adverse reactions | none in the top 1,000 |
| Milsaperidone | adverse reactions | none in the top 1,000 |
| Mosunetuzumab | adverse reactions | none in the top 1,000 |
| Neratinib | adverse reactions | none in the top 1,000 |
| Olanzapine and samidorphan l-malate | adverse reactions | none in the top 1,000 |
| Oliceridine | adverse reactions | none in the top 1,000 |
| Olutasidenib | adverse reactions | none in the top 1,000 |
| Oritavancin | adverse reactions | none in the top 1,000 |
| Ozanimod | adverse reactions | none in the top 1,000 |
| Pasireotide | adverse reactions | none in the top 1,000 |
| Pegzilarginase | adverse reactions | none in the top 1,000 |
| Penpulimab | adverse reactions | none in the top 1,000 |
| Pivekimab sunirine | adverse reactions | none in the top 1,000 |
| Plazomicin | adverse reactions | none in the top 1,000 |
| Ponesimod | adverse reactions | none in the top 1,000 |
| Quizartinib | adverse reactions | none in the top 1,000 |
| Revumenib | adverse reactions | none in the top 1,000 |
| Romidepsin | adverse reactions | none in the top 1,000 |
| Ropeginterferon alfa 2b | adverse reactions | none in the top 1,000 |
| Sevabertinib | adverse reactions | none in the top 1,000 |
| Sonrotoclax | adverse reactions | none in the top 1,000 |
| Soybean oil | adverse reactions | none in the top 1,000 |
| Talazoparib | adverse reactions | none in the top 1,000 |
| Talquetamab | adverse reactions | none in the top 1,000 |
| Tarlatamab-dlle | adverse reactions | none in the top 1,000 |
| Tasimelteon | adverse reactions | none in the top 1,000 |
| Teclistamab | adverse reactions | none in the top 1,000 |
| Teplizumab | adverse reactions | none in the top 1,000 |
| Tipiracil and trifluridine | adverse reactions | none in the top 1,000 |
| Tisotumab vedotin | adverse reactions | none in the top 1,000 |
| Treosulfan | adverse reactions | none in the top 1,000 |
| Vepdegestrant | adverse reactions | none in the top 1,000 |
Source: FDA drug labels via openFDA, read October 8, 2026; FAERS via openFDA, reports through July 30, 2026
Which of them have the most alanine aminotransferase increased reports in FAERS?
Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026; MedDRA preferred term “Alanine Aminotransferase Increased”
What next?
- Side effects across medicines
- every reaction on PlainMeds
- Report a side effect to the FDA
- MedWatch