Side effects across medicines
Medicines whose labels list muscle spasms
182 medicines have an FDA label that names muscle spasms in its boxed warning, warnings, adverse reactions, trial table, patient leaflet or Drug Facts “stop use” warning (of the labels PlainMeds reads: each medicine's quoted label and up to eight more, by route and wording). Among them, the most FAERS reports of muscle spasms name lenalidomide (7,761), teriparatide (5,748) and atorvastatin (5,694), through July 30, 2026. A label lists what its studies and reports found, and a report does not show that a medicine caused the event.
Check it at the source: the FDA FAERS public dashboard; FDA labels on DailyMed.
Which medicines' labels list muscle spasms?
Ordered by where the label names it, the boxed warning first, then by FAERS reports. The first 150 of the 182 are below; every other one is on its medicine record. A medicine whose own indications name it, because it treats it, is not counted.
| Medicine | Where a label names it | FAERS reports of muscle spasms |
|---|---|---|
| Lenalidomide | adverse reactions | 7,761 |
| Teriparatide | adverse reactions | 5,748 |
| Atorvastatin | adverse reactions | 5,694 |
| Pregabalin | adverse reactions | 4,713 |
| Evolocumab | adverse reactions | 3,274 |
| Rituximab | adverse reactions | 2,572 |
| Copper | adverse reactions | 2,509 |
| Vismodegib | adverse reactions | 2,065 |
| Ibrutinib | adverse reactions | 1,780 |
| Sertraline | adverse reactions | 1,756 |
| Erenumab | adverse reactions | 1,610 |
| Pomalidomide | adverse reactions | 1,529 |
| Estradiol | adverse reactions (topical label) | 1,516 |
| Aripiprazole | adverse reactions | 1,256 |
| Mepolizumab | adverse reactions | 1,162 |
| Sodium oxybate | adverse reactions | 1,033 |
| Duloxetine | adverse reactions | 1,018 |
| Tramadol | adverse reactions | 946 |
| Ruxolitinib | adverse reactions | 932 |
| Buprenorphine | adverse reactions (transdermal label) | 903 |
| Abaloparatide | adverse reactions | 867 |
| Palbociclib | adverse reactions | 863 |
| Imatinib | adverse reactions | 860 |
| Fentanyl | adverse reactions (transdermal label) | 854 |
| Botulinum toxin type a | adverse reactions (intradermal/ | 799 |
| Olanzapine | adverse reactions (intramuscular label) | 734 |
| Tizanidine | adverse reactions | 726 |
| Risperidone | adverse reactions | 720 |
| Cabozantinib | adverse reactions | 692 |
| Cinacalcet | adverse reactions | 600 |
| Raloxifene | adverse reactions | 588 |
| Nilotinib | adverse reactions | 509 |
| Eculizumab | adverse reactions | 397 |
| Cyclophosphamide | adverse reactions | 385 |
| Fluticasone and vilanterol | adverse reactions | 368 |
| Moxifloxacin | adverse reactions | 352 |
| Fluticasone and umeclidinium and vilanterol | adverse reactions | 336 |
| Clarithromycin | adverse reactions | 299 |
| Alemtuzumab | adverse reactions | 290 |
| Pitavastatin | adverse reactions | 286 |
| Everolimus | adverse reactions | 260 |
| Ripretinib | adverse reactions | 259 |
| Lurasidone | adverse reactions | 255 |
| Sorafenib | adverse reactions | 249 |
| Carfilzomib | adverse reactions | 245 |
| Abiraterone | adverse reactions | 244 |
| Calcium oxybate, magnesium oxybate, potassium oxybate and sodium oxybate | adverse reactions | 230 |
| Rifaximin | adverse reactions | 218 |
| Filgrastim | adverse reactions | 211 |
| Regorafenib | adverse reactions | 202 |
| Sonidegib | adverse reactions | 195 |
| Ospemifene | adverse reactions | 194 |
| Ravulizumab | adverse reactions | 191 |
| Umeclidinium and vilanterol | adverse reactions | 190 |
| Lacosamide | adverse reactions | 178 |
| Lubiprostone | adverse reactions | 178 |
| Hydrocodone | adverse reactions | 177 |
| Bempedoic acid | adverse reactions | 169 |
| Buspirone | adverse reactions | 166 |
| Romosozumab | adverse reactions | 149 |
| Paliperidone | adverse reactions | 147 |
| Febuxostat | adverse reactions | 144 |
| Budesonide and formoterol and glycopyrrolate | adverse reactions | 142 |
| Eltrombopag | adverse reactions | 136 |
| Fluvastatin | adverse reactions | 134 |
| Aclidinium | adverse reactions | 121 |
| Cariprazine | adverse reactions | 118 |
| Clobazam | adverse reactions | 118 |
| Amifampridine | adverse reactions | 110 |
| Dasatinib | adverse reactions | 104 |
| Vigabatrin | adverse reactions | 104 |
| Burosumab | adverse reactions | 101 |
| Calcium chloride, dextrose, magnesium chloride, sodium chloride and sodium lactate | adverse reactions (intraperitoneal label) | 89 |
| Roflumilast | adverse reactions | 88 |
| Trastuzumab emtansine | adverse reactions | 84 |
| Asenapine | adverse reactions | 81 |
| Ziconotide | adverse reactions | 79 |
| Ethinyl estradiol and norgestimate | adverse reactions | 78 |
| Paricalcitol | adverse reactions | 78 |
| Dichlorphenamide | adverse reactions | 77 |
| Omaveloxolone | adverse reactions | 75 |
| Neratinib | adverse reactions | 74 |
| Aclidinium and formoterol | adverse reactions | none in the top 1,000 |
| Agalsidase beta | adverse reactions | none in the top 1,000 |
| Alosetron | adverse reactions | none in the top 1,000 |
| Amiodarone | adverse reactions (intravenous label) | none in the top 1,000 |
| Amlodipine and atorvastatin | adverse reactions | none in the top 1,000 |
| Amlodipine and benazepril | adverse reactions | none in the top 1,000 |
| Amlodipine and hydrochlorothiazide and olmesartan | adverse reactions | none in the top 1,000 |
| Amlodipine and hydrochlorothiazide and valsartan | adverse reactions | none in the top 1,000 |
| Amoxicillin and clarithromycin and lansoprazole | adverse reactions | none in the top 1,000 |
| Asparaginase | adverse reactions | none in the top 1,000 |
| Avanafil | adverse reactions | none in the top 1,000 |
| Baxdrostat | adverse reactions | none in the top 1,000 |
| Bazedoxifene and estrogens conjugated | adverse reactions | none in the top 1,000 |
| Belzutifan | adverse reactions | none in the top 1,000 |
| Bempedoic acid and ezetimibe | adverse reactions | none in the top 1,000 |
| Brentuximab vedotin | adverse reactions | none in the top 1,000 |
| Brigatinib | adverse reactions | none in the top 1,000 |
| Cabazitaxel | adverse reactions | none in the top 1,000 |
| Cedazuridine and decitabine | adverse reactions | none in the top 1,000 |
| Cipaglucosidase alfa | adverse reactions | none in the top 1,000 |
| Daratumumab | adverse reactions | none in the top 1,000 |
| Daratumumab and hyaluronidase | adverse reactions | none in the top 1,000 |
| Decitabine | adverse reactions | none in the top 1,000 |
| Deferoxamine | adverse reactions | none in the top 1,000 |
| Deflazacort | adverse reactions | none in the top 1,000 |
| Elinzanetant | adverse reactions | none in the top 1,000 |
| Elotuzumab | adverse reactions | none in the top 1,000 |
| Elranatamab | adverse reactions | none in the top 1,000 |
| Eribulin | adverse reactions | none in the top 1,000 |
| Ertapenem | adverse reactions | none in the top 1,000 |
| Esomeprazole and naproxen | adverse reactions | none in the top 1,000 |
| Etelcalcetide | adverse reactions | none in the top 1,000 |
| Ethinyl estradiol and levonorgestrel | adverse reactions | none in the top 1,000 |
| Ethinyl estradiol and norelgestromin | adverse reactions | none in the top 1,000 |
| Ethinyl estradiol and norethindrone | adverse reactions (oral label) | none in the top 1,000 |
| Fedratinib | adverse reactions | none in the top 1,000 |
| Fenofibric acid | adverse reactions | none in the top 1,000 |
| Ferric derisomaltose | adverse reactions | none in the top 1,000 |
| Fexinidazole | adverse reactions | none in the top 1,000 |
| Formoterol and glycopyrrolate | adverse reactions | none in the top 1,000 |
| Galantamine | adverse reactions | none in the top 1,000 |
| Ganciclovir | adverse reactions | none in the top 1,000 |
| Gepotidacin | adverse reactions | none in the top 1,000 |
| Gilteritinib | adverse reactions | none in the top 1,000 |
| Glasdegib | adverse reactions | none in the top 1,000 |
| Hyaluronidase and pertuzumab and trastuzumab | adverse reactions | none in the top 1,000 |
| Hyaluronidase and rituximab | adverse reactions | none in the top 1,000 |
| Iberdomide | adverse reactions | none in the top 1,000 |
| Ifosfamide | adverse reactions | none in the top 1,000 |
| Iloperidone | adverse reactions | none in the top 1,000 |
| Interferon gamma 1b | adverse reactions | none in the top 1,000 |
| Iohexol | adverse reactions | none in the top 1,000 |
| Ioversol | adverse reactions | none in the top 1,000 |
| Isatuximab | adverse reactions (subcutaneous label) | none in the top 1,000 |
| Ivosidenib | adverse reactions | none in the top 1,000 |
| Ixabepilone | adverse reactions | none in the top 1,000 |
| Lumateperone | adverse reactions | none in the top 1,000 |
| Methoxy polyethylene glycol-epoetin beta | adverse reactions | none in the top 1,000 |
| Methylnaltrexone | adverse reactions | none in the top 1,000 |
| Milsaperidone | adverse reactions | none in the top 1,000 |
| Mogamulizumab | adverse reactions | none in the top 1,000 |
| Nipocalimab | adverse reactions | none in the top 1,000 |
| Olanzapine and samidorphan l-malate | adverse reactions | none in the top 1,000 |
| Oliceridine | adverse reactions | none in the top 1,000 |
| Patisiran | adverse reactions | none in the top 1,000 |
| Phentermine and topiramate | adverse reactions | none in the top 1,000 |
| Ponatinib | adverse reactions | none in the top 1,000 |
| Raxibacumab | adverse reactions | none in the top 1,000 |
Source: FDA drug labels via openFDA, read October 8, 2026; FAERS via openFDA, reports through July 30, 2026
Which of them have the most muscle spasms reports in FAERS?
Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026; MedDRA preferred term “Muscle Spasms”
What next?
- Side effects across medicines
- every reaction on PlainMeds
- Report a side effect to the FDA
- MedWatch