esomeprazole

Interaction Drug Interaction Rifabutin, phenytoin, efavirenz, cimetidine, esomeprazole* Avoid coadministration unless the benefit outweighs the risks ( 7.6 , 7.7 , 7.8 , 7.9 ) Other drugs metabolized by CYP3A4 Consider dosage adjustment and monitor for adverse effects and toxicity ( 7.1 , 7.10 , 7.11 ) Digoxin Monitor digoxin plasma concentrations ( 7.12 ) Fosamprenavir, metoclopramide* Monitor for breakthrough fungal infections ( 7.6 , 7.13 ) *The drug interactions with esomeprazole and metoclopramide do not apply to posaconazole tablets.

Mechanism: Esomeprazole changes the acid levels in the stomach, which can prevent certain forms of posaconazole from being absorbed into the body. This may make the antifungal treatment less effective.

What to do: Avoid taking these together unless your doctor determines the benefits are greater than the risks. Note that this warning may not apply if you are taking the tablet form of posaconazole.

Omeprazole or Esomeprazole Avoid concomitant use of clopidogrel with omeprazole or esomeprazole. A similar reduction in antiplatelet activity was observed with esomeprazole when given concomitantly with clopidogrel. Dexlansoprazole, lansoprazole, and pantoprazole had less effect on the antiplatelet activity of clopidogrel than did omeprazole or esomeprazole [see Warnings and Precautions (5.1) and Clinical Pharmacology (12.3) ].

Mechanism: Esomeprazole keeps clopidogrel from being activated in your body. This prevents the blood thinner from doing its job of protecting your heart and blood vessels.

What to do: You should avoid this combination. Talk to your doctor about using a different stomach medicine that does not interfere with your treatment.

Conivaptan 33% 43% Diltiazem 20% NA Indomethacin 40% NA Mirabegron 29% 27% Nefazodone 27% 15% Nifedipine 45% NA Propantheline 24% 24% Quinine NA 33% Rabeprazole 29% 19% Saquinavir 27% 49% Spironolactone 25% NA Telmisartan 20 to 49% NA Tricagrelor 31% 28% Tolvaptan 30% 20% Trimethoprim 22 to 28% NA Digoxin concentrations increased, but magnitude is unclear Alprazolam, azithromycin, cyclosporine, diclofenac, diphenoxylate, epoprostenol, esomeprazole, ibuprofen, ketoconazole, lansoprazole, metformin, omeprazole Measure serum digoxin concentrations before initiating concomitant drugs.

Mechanism: Taking esomeprazole can raise the levels of digoxin in your body. It likely changes how much of the drug is absorbed or handled by your system.

What to do: Have your digoxin blood levels tested before starting esomeprazole. Your healthcare provider will decide if your dose needs to be changed to keep you safe.

Co-administration of risedronate sodium with the PPI, esomeprazole, increased risedronate bioavailability.

Mechanism: This acid-reducing medicine can cause your body to absorb a larger amount of the bone medication than it normally would.

What to do: Your doctor may need to monitor you more closely for side effects since more of the drug is entering your system.

Failed Impurities/Degradation Specifications: Out-of-Specification test results obtained for any individual unknown degradation product during Related Compounds testing during long term stability.

Zydus Pharmaceuticals (USA) Inc

Labeling: Not Elsewhere Classified - Wrong NDC number

Zydus Pharmaceuticals (USA) Inc