HIGH-VOLUME · SEX-BALANCED
folic acid Side Effects
folic acid (also sold as Folvite) is HIGH-VOLUME in this FAERS book #21 of 524 by FAERS report count. Signature opener: SEX-BALANCED - 68% of sex-coded reports are female (152,545 F / 70,365 M).
Data updated 2026-05-15
- 241,433
- FAERS reports
FAERS voluntary reports, 2003 to 2025. High volume tracks exposure and reporting culture; see methodology for de-dup rules.
folic acid reporting skew - 68% of sex-coded reports are female (152,545 F / 70,365 M). Volume band HIGH-VOLUME #21 of 524 by FAERS report count; caseload MEGA-CASE.
High-report extract for folic acid (Folvite): 241,433 FAERS rows (2003-2025). Top named reactions: FATIGUE, PAIN, ARTHRALGIA. Outcome stamps DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED. FAERS is voluntary signal detection, not incidence.
Counts from the openFDA FAERS extract (2003–2025). Stamps MEGA-CASE · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
FATIGUE leads 23,332 of 241,433 reports
Who reports · age peak 45-64 (SEX-BALANCED)
Sex coding · SEX-BALANCED
Age peak 45-64 (61,818 reports)
FAERS filings rising toward 2025
Reactions in Death Reports
Death-mentioned subset is HEAVY here (22,144 reports, 9.2%). Top co-reported reactions in that subset - voluntary, not causal.
| Reaction | Reports |
|---|---|
| DEATH | 5,981 |
| PNEUMONIA | 2,632 |
| GENERAL PHYSICAL HEALTH DETERIORATION | 2,540 |
| FATIGUE | 2,504 |
| DIARRHOEA | 2,332 |
| VOMITING | 2,210 |
| DYSPNOEA | 2,194 |
| RHEUMATOID ARTHRITIS | 2,150 |
| RASH | 2,134 |
| HYPERTENSION | 2,133 |
| SYSTEMIC LUPUS ERYTHEMATOSUS | 2,117 |
| TYPE 2 DIABETES MELLITUS | 2,082 |
| PAIN | 2,077 |
| HYPOAESTHESIA | 2,027 |
| GLOSSODYNIA | 2,014 |
| INFUSION RELATED REACTION | 2,006 |
| DUODENAL ULCER PERFORATION | 1,998 |
| ARTHRALGIA | 1,997 |
| FIBROMYALGIA | 1,992 |
Reactions in Hospitalization Reports
Hospitalization is HEAVY (87,188, 36.1% of the book). Top reactions in those rows:
| Reaction | Reports |
|---|---|
| FATIGUE | 7,987 |
| PNEUMONIA | 7,501 |
| PAIN | 7,490 |
| DYSPNOEA | 7,236 |
| ARTHRALGIA | 6,934 |
| DIARRHOEA | 6,899 |
| NAUSEA | 6,613 |
| PYREXIA | 6,481 |
| VOMITING | 6,128 |
| FALL | 5,610 |
| RHEUMATOID ARTHRITIS | 5,556 |
| HEADACHE | 5,140 |
| ASTHENIA | 5,132 |
| RASH | 5,102 |
| CONDITION AGGRAVATED | 4,886 |
| MALAISE | 4,867 |
| DIZZINESS | 4,620 |
| GENERAL PHYSICAL HEALTH DETERIORATION | 4,163 |
How to read folic acid FAERS figures (MEGA-CASE · DEATH-HEAVY · HOSP-HEAVY)
FAERS holds 241,433 voluntary reports linked to folic acid (Folvite), 2003-2025. Death is listed on 22,144 (9.2%). Hospitalization appears on 87,188 (36.1%). Top co-reported indication: Product Used For Unknown Indication.
MEGA-CASE books overweight common drugs and loud reporting cultures; SEX-BALANCED is the page opener, not a per-patient risk.
Read with folic acid
Peers ranked by ABS(total_reports), then an ABS(death_share) pole; guide hop follows DEATH-HEAVY · HOSP-HEAVY stamps.
ABS(total_reports) peer at 240,800 FAERS cases (Δ 633 lighter vs folic acid); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's MEGA-CASE · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(total_reports) peer at 240,204 FAERS cases (Δ 1,229 lighter vs folic acid); DEATH-HEAVY · HOSP-MID · SEX-BALANCED vs this page's MEGA-CASE · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(total_reports) peer at 245,754 FAERS cases (Δ 4,321 heavier vs folic acid); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's MEGA-CASE · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(total_reports) peer at 246,252 FAERS cases (Δ 4,819 heavier vs folic acid); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's MEGA-CASE · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(death_share) pole at 62.1% death-mentioned reports (Δ 52.9 pp vs folic acid's DEATH-HEAVY): CASELOAD · HOSP-MID.
folic acid stamps DEATH-HEAVY · HOSP-HEAVY; FAERS outcome shares are signal-detection rates, not incidence. Read them next to caseload MEGA-CASE and the label guide.