Side effects across medicines
Medicines whose labels list joint pain
715 medicines have an FDA label that names joint pain (arthralgia) in its boxed warning, warnings, adverse reactions, trial table, patient leaflet or Drug Facts “stop use” warning (of the labels PlainMeds reads: each medicine's quoted label and up to eight more, by route and wording). Among them, the most FAERS reports of joint pain name adalimumab (48,593), methotrexate (40,408) and tofacitinib (19,961), through July 30, 2026. A label lists what its studies and reports found, and a report does not show that a medicine caused the event.
Check it at the source: the FDA FAERS public dashboard; FDA labels on DailyMed.
Which medicines' labels list joint pain?
Ordered by where the label names it, the boxed warning first, then by FAERS reports. The first 150 of the 715 are below; every other one is on its medicine record. A medicine whose own indications name it, because it treats it, is not counted.
| Medicine | Where a label names it | FAERS reports of joint pain |
|---|---|---|
| Pantoprazole | warnings and precautions (intravenous label) | 12,261 |
| Esomeprazole | warnings and precautions (intravenous label) | 6,593 |
| Ciprofloxacin | warnings and precautions (intravenous label) | 5,587 |
| Sulfamethoxazole and trimethoprim | precautions | 2,868 |
| Levofloxacin | warnings and precautions (intravenous label) | 2,321 |
| Moxifloxacin | warnings and precautions (intravenous label) | 838 |
| Ofloxacin | warnings (oral label) | 252 |
| Bupivacaine | warnings and precautions (subarachnoid label) | 160 |
| Amoxicillin and clarithromycin and lansoprazole | warnings | none in the top 1,000 |
| Bacillus calmette-guerin substrain tice live antigen | precautions | none in the top 1,000 |
| Mepivacaine | warnings (infiltration label) | none in the top 1,000 |
| Mesna | warnings and precautions (oral label) | none in the top 1,000 |
| Obinutuzumab | warnings and precautions | none in the top 1,000 |
| Procainamide | precautions | none in the top 1,000 |
| Adalimumab | adverse reactions | 48,593 |
| Methotrexate | adverse reactions | 40,408 |
| Tofacitinib | adverse reactions | 19,961 |
| Dupilumab | adverse reactions | 19,297 |
| Infliximab | adverse reactions | 17,737 |
| Omeprazole | adverse reactions | 13,682 |
| Sulfasalazine | adverse reactions | 13,481 |
| Rituximab | adverse reactions | 13,299 |
| Levothyroxine | adverse reactions | 12,926 |
| Celecoxib | adverse reactions | 11,256 |
| Certolizumab | adverse reactions | 10,982 |
| Lisinopril | adverse reactions | 9,649 |
| Pregabalin | adverse reactions | 9,530 |
| Denosumab | adverse reactions | 8,912 |
| Atorvastatin | adverse reactions | 8,721 |
| Teriparatide | adverse reactions | 8,702 |
| Amlodipine | adverse reactions | 7,953 |
| Simvastatin | adverse reactions | 7,699 |
| Oxycodone | adverse reactions | 7,527 |
| Metoprolol | adverse reactions | 7,473 |
| Losartan | adverse reactions | 6,625 |
| Apremilast | adverse reactions | 6,436 |
| Azathioprine | adverse reactions | 5,866 |
| Ustekinumab | adverse reactions | 5,825 |
| Adalimumab-aaty | adverse reactions | 5,250 |
| Adalimumab-fkjp | adverse reactions | 5,202 |
| Ramipril | adverse reactions | 5,185 |
| Vedolizumab | adverse reactions | 4,739 |
| Clonazepam | adverse reactions | 4,371 |
| Montelukast | adverse reactions | 4,240 |
| Fluticasone | adverse reactions (respiratory (inhalation) label) | 4,231 |
| Quetiapine | adverse reactions | 4,111 |
| Evolocumab | adverse reactions | 4,061 |
| Citalopram | adverse reactions | 3,972 |
| Letrozole | adverse reactions | 3,957 |
| Clopidogrel | adverse reactions | 3,955 |
| Escitalopram | adverse reactions | 3,904 |
| Risedronate | adverse reactions | 3,876 |
| Bisoprolol | adverse reactions | 3,842 |
| Lenalidomide | adverse reactions | 3,817 |
| Omalizumab | adverse reactions | 3,811 |
| Allopurinol | adverse reactions | 3,672 |
| Zolpidem | adverse reactions | 3,596 |
| Rosuvastatin | adverse reactions | 3,437 |
| Sertraline | adverse reactions | 3,241 |
| Anastrozole | adverse reactions | 3,230 |
| Zoledronic acid | adverse reactions | 3,219 |
| Risankizumab | adverse reactions | 3,089 |
| Natalizumab | adverse reactions | 3,055 |
| Ezetimibe | adverse reactions | 3,053 |
| Carvedilol | adverse reactions | 3,044 |
| Valsartan | adverse reactions | 3,029 |
| Mycophenolate mofetil | adverse reactions | 2,992 |
| Estradiol | adverse reactions (oral label) | 2,944 |
| Mesalamine | adverse reactions | 2,940 |
| Bupropion | adverse reactions | 2,913 |
| Interferon beta 1a | adverse reactions (intramuscular label) | 2,755 |
| Ranitidine | adverse reactions | 2,741 |
| Treprostinil | adverse reactions | 2,733 |
| Topiramate | adverse reactions | 2,600 |
| Lamotrigine | adverse reactions | 2,450 |
| Cyclosporine | adverse reactions | 2,431 |
| Tiotropium | adverse reactions | 2,396 |
| Abaloparatide | adverse reactions | 2,343 |
| Tadalafil | adverse reactions | 2,317 |
| Ibrutinib | adverse reactions | 2,209 |
| Mirtazapine | adverse reactions | 2,175 |
| Enzalutamide | adverse reactions | 2,152 |
| Tramadol | adverse reactions | 2,050 |
| Mepolizumab | adverse reactions | 1,968 |
| Isotretinoin | adverse reactions | 1,966 |
| Leuprolide | adverse reactions | 1,964 |
| Pembrolizumab | adverse reactions | 1,906 |
| Budesonide | adverse reactions (oral label) | 1,870 |
| Fluticasone and salmeterol | adverse reactions | 1,869 |
| Sitagliptin | adverse reactions | 1,746 |
| Exemestane | adverse reactions | 1,724 |
| Metronidazole | adverse reactions | 1,715 |
| Valacyclovir | adverse reactions | 1,658 |
| Octreotide | adverse reactions | 1,654 |
| Selexipag | adverse reactions | 1,637 |
| Ribavirin | adverse reactions | 1,512 |
| Nivolumab | adverse reactions | 1,501 |
| Mirabegron | adverse reactions | 1,492 |
| Estrogens conjugated | adverse reactions | 1,488 |
| Peginterferon alfa 2a | adverse reactions | 1,475 |
| Dexlansoprazole | adverse reactions | 1,431 |
| Fulvestrant | adverse reactions | 1,425 |
| Buprenorphine | adverse reactions (transdermal label) | 1,413 |
| Ribociclib | adverse reactions | 1,405 |
| Enalapril | adverse reactions | 1,403 |
| Pegvaliase | adverse reactions | 1,395 |
| Bevacizumab | adverse reactions (intravascular label) | 1,392 |
| Cyclophosphamide | adverse reactions | 1,364 |
| Aripiprazole | adverse reactions | 1,354 |
| Fingolimod | adverse reactions | 1,348 |
| Trastuzumab | adverse reactions | 1,317 |
| Rabeprazole | adverse reactions | 1,304 |
| Azithromycin | adverse reactions | 1,261 |
| Tacrolimus | adverse reactions | 1,249 |
| Paclitaxel | adverse reactions | 1,238 |
| Empagliflozin | adverse reactions | 1,207 |
| Anakinra | adverse reactions | 1,198 |
| Clonidine | adverse reactions | 1,184 |
| Fenofibrate | adverse reactions | 1,176 |
| Paroxetine | adverse reactions | 1,142 |
| Levetiracetam | adverse reactions | 1,113 |
| Nilotinib | adverse reactions | 1,089 |
| Eculizumab | adverse reactions | 1,071 |
| Telmisartan | adverse reactions | 1,041 |
| Vemurafenib | adverse reactions | 1,039 |
| Nifedipine | adverse reactions | 1,016 |
| Docetaxel | adverse reactions | 1,008 |
| Minocycline | adverse reactions | 988 |
| Guselkumab | adverse reactions | 956 |
| Human immunoglobulin g | adverse reactions | 936 |
| Cabozantinib | adverse reactions | 934 |
| Capecitabine | adverse reactions | 920 |
| Everolimus | adverse reactions | 916 |
| Somatropin | adverse reactions | 908 |
| Varenicline | adverse reactions | 897 |
| Lenvatinib | adverse reactions | 894 |
| Methylphenidate | adverse reactions | 876 |
| Olanzapine | adverse reactions | 853 |
| Teriflunomide | adverse reactions | 853 |
| Inclisiran | adverse reactions | 846 |
| Tizanidine | adverse reactions | 845 |
| Pomalidomide | adverse reactions | 839 |
| Cephalexin | adverse reactions | 818 |
| Lovastatin | adverse reactions | 818 |
| Fluticasone and umeclidinium and vilanterol | adverse reactions | 812 |
| Botulinum toxin type a | adverse reactions (intradermal/ | 801 |
| Isosorbide mononitrate | adverse reactions | 798 |
| Diclofenac and misoprostol | adverse reactions | 780 |
| Fluticasone and vilanterol | adverse reactions | 779 |
| Linagliptin | adverse reactions | 770 |
Source: FDA drug labels via openFDA, read October 8, 2026; FAERS via openFDA, reports through July 30, 2026
Which of them have the most joint pain reports in FAERS?
Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026; MedDRA preferred term “Arthralgia”
What next?
- Side effects across medicines
- every reaction on PlainMeds
- Report a side effect to the FDA
- MedWatch