HIGH-VOLUME · HOSP-HEAVY
pantoprazole Side Effects
pantoprazole (also sold as Protonix) is HIGH-VOLUME in this FAERS book #22 of 524 by FAERS report count. Signature opener: HOSP-HEAVY - 46.3% mention hospitalization (111,504 reports).
Data updated 2026-05-15
- 240,800
- FAERS reports
FAERS voluntary reports, 2003 to 2025. High volume tracks exposure and reporting culture; see methodology for de-dup rules.
pantoprazole: 46.3% mention hospitalization (111,504 reports). Death stamp DEATH-HEAVY; volume band HIGH-VOLUME #22 of 524 by FAERS report count.
High-report extract for pantoprazole (Protonix): 240,800 FAERS rows (2003-2025). Top named reactions: FATIGUE, NAUSEA, DIARRHOEA. Outcome stamps DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED. FAERS is voluntary signal detection, not incidence.
Counts from the openFDA FAERS extract (2003–2025). Stamps MEGA-CASE · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
FATIGUE leads 19,879 of 240,800 reports
Who reports · age peak 45-64 (SEX-BALANCED)
Sex coding · SEX-BALANCED
Age peak 45-64 (57,494 reports)
FAERS filings rising toward 2025
Reactions in Death Reports
Death-mentioned subset is HEAVY here (27,099 reports, 11.3%). Top co-reported reactions in that subset - voluntary, not causal.
| Reaction | Reports |
|---|---|
| DEATH | 8,323 |
| PNEUMONIA | 2,343 |
| GENERAL PHYSICAL HEALTH DETERIORATION | 2,285 |
| DYSPNOEA | 2,148 |
| DIARRHOEA | 2,131 |
| FATIGUE | 2,130 |
| VOMITING | 1,931 |
| PYREXIA | 1,776 |
| ASTHENIA | 1,773 |
| NAUSEA | 1,748 |
| ACUTE KIDNEY INJURY | 1,726 |
| PAIN | 1,693 |
| HYPERTENSION | 1,613 |
| RASH | 1,584 |
| CONDITION AGGRAVATED | 1,560 |
| CONFUSIONAL STATE | 1,501 |
| DECREASED APPETITE | 1,497 |
| HEADACHE | 1,444 |
| ARTHRALGIA | 1,431 |
Reactions in Hospitalization Reports
Hospitalization is HEAVY (111,504, 46.3% of the book). Top reactions in those rows:
| Reaction | Reports |
|---|---|
| DYSPNOEA | 9,997 |
| NAUSEA | 8,886 |
| FATIGUE | 8,686 |
| DIARRHOEA | 8,583 |
| PNEUMONIA | 7,629 |
| VOMITING | 7,598 |
| PYREXIA | 7,404 |
| PAIN | 6,616 |
| ASTHENIA | 6,614 |
| GENERAL PHYSICAL HEALTH DETERIORATION | 6,182 |
| FALL | 5,878 |
| ANAEMIA | 5,539 |
| HEADACHE | 5,467 |
| ACUTE KIDNEY INJURY | 5,453 |
| DIZZINESS | 5,316 |
| ARTHRALGIA | 4,987 |
| ABDOMINAL PAIN | 4,983 |
| CONDITION AGGRAVATED | 4,976 |
How to read pantoprazole FAERS figures (MEGA-CASE · DEATH-HEAVY · HOSP-HEAVY)
FAERS holds 240,800 voluntary reports linked to pantoprazole (Protonix), 2003-2025. Death is listed on 27,099 (11.3%). Hospitalization appears on 111,504 (46.3%). Top co-reported indication: Product Used For Unknown Indication.
MEGA-CASE books overweight common drugs and loud reporting cultures; HOSP-HEAVY is the page opener, not a per-patient risk.
Read with pantoprazole
Peers ranked by ABS(total_reports), then an ABS(death_share) pole; guide hop follows DEATH-HEAVY · HOSP-HEAVY stamps.
ABS(total_reports) peer at 240,204 FAERS cases (Δ 596 lighter vs pantoprazole); DEATH-HEAVY · HOSP-MID · SEX-BALANCED vs this page's MEGA-CASE · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(total_reports) peer at 241,433 FAERS cases (Δ 633 heavier vs pantoprazole); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's MEGA-CASE · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(total_reports) peer at 236,147 FAERS cases (Δ 4,653 lighter vs pantoprazole); DEATH-HEAVY · HOSP-MID · SEX-BALANCED vs this page's MEGA-CASE · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(total_reports) peer at 245,754 FAERS cases (Δ 4,954 heavier vs pantoprazole); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's MEGA-CASE · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(death_share) pole at 62.1% death-mentioned reports (Δ 50.9 pp vs pantoprazole's DEATH-HEAVY): CASELOAD · HOSP-MID.
pantoprazole stamps DEATH-HEAVY · HOSP-HEAVY; FAERS outcome shares are signal-detection rates, not incidence. Read them next to caseload MEGA-CASE and the label guide.