Side effects across medicines
Medicines whose labels list hypersensitivity
1,005 medicines have an FDA label that names hypersensitivity in its boxed warning, warnings, adverse reactions, trial table, patient leaflet or Drug Facts “stop use” warning (of the labels PlainMeds reads: each medicine's quoted label and up to eight more, by route and wording). Among them, the most FAERS reports of hypersensitivity name etanercept (14,142), adalimumab (13,415) and methotrexate (13,072), through July 30, 2026. A label lists what its studies and reports found, and a report does not show that a medicine caused the event.
Check it at the source: the FDA FAERS public dashboard; FDA labels on DailyMed.
Which medicines' labels list hypersensitivity?
Ordered by where the label names it, the boxed warning first, then by FAERS reports. The first 150 of the 1,005 are below; every other one is on its medicine record. A medicine whose own indications name it, because it treats it, is not counted.
| Medicine | Where a label names it | FAERS reports of hypersensitivity |
|---|---|---|
| Methotrexate | boxed warning (intra-arterial/ | 13,072 |
| Cabazitaxel | boxed warning | none in the top 1,000 |
| Cerliponase alfa | boxed warning | none in the top 1,000 |
| Laronidase | boxed warning | none in the top 1,000 |
| Melphalan | boxed warning (intravenous label) | none in the top 1,000 |
| Rasburicase | boxed warning | none in the top 1,000 |
| Raxibacumab | boxed warning | none in the top 1,000 |
| Albuterol | warnings (oral label) | 5,579 |
| Adalimumab-aaty | warnings and precautions | 3,326 |
| Adalimumab-fkjp | warnings and precautions | 3,307 |
| Fluticasone | warnings and precautions (respiratory (inhalation) label) | 2,574 |
| Azathioprine | precautions | 2,402 |
| Sulfamethoxazole and trimethoprim | precautions | 2,210 |
| Ondansetron | warnings and precautions (intramuscular/ | 1,719 |
| Ciprofloxacin | warnings and precautions (intravenous label) | 1,585 |
| Paclitaxel | precautions | 1,467 |
| Aprepitant | warnings and precautions (intravenous label) | 1,182 |
| Moxifloxacin | warnings and precautions (ophthalmic label) | 1,095 |
| Bevacizumab | warnings and precautions (intravascular label) | 951 |
| Mesalamine | warnings and precautions (rectal label) | 938 |
| Botulinum toxin type a | warnings and precautions (intradermal/ | 778 |
| Levetiracetam | warnings and precautions (intravenous label) | 766 |
| Carbamazepine | precautions | 715 |
| Brimonidine | warnings and precautions (topical label) | 696 |
| Levofloxacin | warnings and precautions (ophthalmic label) | 676 |
| Buprenorphine | warnings (intramuscular/ | 651 |
| Sumatriptan | warnings and precautions (subcutaneous label) | 622 |
| Ipratropium | warnings (respiratory (inhalation) label) | 566 |
| Minocycline | warnings and precautions (topical label) | 536 |
| Insulin aspart | warnings and precautions (intravenous/ | 452 |
| Indomethacin | warnings and precautions (rectal label) | 435 |
| Insulin human | warnings and precautions (subcutaneous label) | 386 |
| Iron sucrose | warnings and precautions (intravenous/ | 355 |
| Leucovorin | warnings and precautions (oral label) | 308 |
| Nirmatrelvir and ritonavir | warnings and precautions | 285 |
| Penicillin g | warnings (intramuscular/ | 285 |
| Buprenorphine and naloxone | warnings and precautions (buccal/ | 272 |
| Piperacillin and tazobactam | warnings and precautions (intravenous/ | 259 |
| Ketoconazole | warnings (oral label) | 233 |
| Phenytoin | warnings and precautions (intramuscular/ | 206 |
| Interferon beta 1b | warnings and precautions | 190 |
| Obinutuzumab | warnings and precautions | 178 |
| Cefazolin | warnings (intravenous/ | 169 |
| Doxepin | precautions (topical label) | 168 |
| Granisetron | warnings and precautions (subcutaneous label) | 145 |
| Fludarabine | precautions | 142 |
| Rifampin | precautions | 124 |
| Amikacin | warnings and precautions (respiratory (inhalation) label) | 122 |
| Alteplase | warnings and precautions | 108 |
| Haloperidol | warnings (intramuscular label) | 108 |
| Iopamidol | warnings and precautions (intrathecal label) | 106 |
| Clindamycin | warnings (intramuscular/ | 99 |
| Atropine | warnings and precautions (endotracheal/ | 91 |
| Hydrochlorothiazide and triamterene | precautions | 85 |
| Levalbuterol | warnings and precautions (oral label) | 81 |
| Acetaminophen and ibuprofen | warnings and precautions (intravenous label) | none in the top 1,000 |
| Adalimumab-adbm | warnings and precautions | none in the top 1,000 |
| Adalimumab-afzb | warnings and precautions | none in the top 1,000 |
| Alanine, arginine and 15 other ingredients | warnings and precautions | none in the top 1,000 |
| Amiodarone | warnings and precautions (intravenous label) | none in the top 1,000 |
| Amoxicillin and clarithromycin and lansoprazole | precautions | none in the top 1,000 |
| Ampicillin | precautions (oral label) | none in the top 1,000 |
| Anifrolumab | warnings and precautions | none in the top 1,000 |
| Anti-inhibitor coagulant complex | warnings and precautions | none in the top 1,000 |
| Antihemophilic factor and fc-vwf-xten fusion protein-ehtl | warnings and precautions | none in the top 1,000 |
| Apadamtase alfa | warnings and precautions | none in the top 1,000 |
| Asciminib | warnings and precautions | none in the top 1,000 |
| Ascorbic acid, peg 3350 and 4 other ingredients | warnings and precautions | none in the top 1,000 |
| Ascorbic acid, polyethylene glycol 3350 and 4 other ingredients | warnings and precautions | none in the top 1,000 |
| Asenapine | warnings and precautions (transdermal label) | none in the top 1,000 |
| Axatilimab | warnings and precautions | none in the top 1,000 |
| Cabotegravir | warnings and precautions | none in the top 1,000 |
| Cabotegravir and rilpivirine | warnings and precautions | none in the top 1,000 |
| Calcitonin salmon | warnings and precautions (nasal label) | none in the top 1,000 |
| Calcium chloride and potassium chloride and sodium chloride | warnings and precautions (intravenous label) | none in the top 1,000 |
| Cetrorelix | precautions | none in the top 1,000 |
| Chorionic gonadotropin | warnings | none in the top 1,000 |
| Coagulation factor ix | warnings and precautions | none in the top 1,000 |
| Coagulation factor ix recombinant and glycopegylated | warnings and precautions | none in the top 1,000 |
| Coagulation factor x human | warnings and precautions | none in the top 1,000 |
| Cobaltous and technetium tc 99m exametazime | warnings and precautions | none in the top 1,000 |
| Cosyntropin | warnings and precautions (intramuscular/ | none in the top 1,000 |
| Degarelix | warnings and precautions | none in the top 1,000 |
| Desmopressin | warnings and precautions (intravenous/ | none in the top 1,000 |
| Dexamethasone and neomycin and polymyxin b | warnings (topical label) | none in the top 1,000 |
| Doxercalciferol | warnings and precautions (oral label) | none in the top 1,000 |
| Elexacaftor and ivacaftor and tezacaftor | warnings and precautions | none in the top 1,000 |
| Etranacogene dezaparvovec | warnings and precautions | none in the top 1,000 |
| Fluocinolone | precautions | none in the top 1,000 |
| Flurbiprofen | warnings and precautions (oral label) | none in the top 1,000 |
| Fosfomycin | warnings and precautions (intravenous label) | none in the top 1,000 |
| Ganirelix | precautions | none in the top 1,000 |
| Glucagon | warnings and precautions (intravenous label) | none in the top 1,000 |
| Gozetotide | warnings and precautions | none in the top 1,000 |
| Hyaluronidase and pertuzumab and trastuzumab | warnings and precautions | none in the top 1,000 |
| Hyaluronidase and rituximab | warnings and precautions | none in the top 1,000 |
| Hyaluronidase and trastuzumab | warnings and precautions | none in the top 1,000 |
| Hydrocortisone and neomycin and polymyxin b | warnings (ophthalmic label) | none in the top 1,000 |
| Hydroxocobalamin | warnings and precautions (intravenous label) | none in the top 1,000 |
| Indium in -111 pentetreotide | warnings | none in the top 1,000 |
| Indocyanine green | warnings and precautions | none in the top 1,000 |
| Indocyanine green and water | warnings and precautions | none in the top 1,000 |
| Isatuximab | warnings and precautions (subcutaneous label) | none in the top 1,000 |
| Ivacaftor and tezacaftor | warnings and precautions | none in the top 1,000 |
| Ketorolac | precautions (oral label) | none in the top 1,000 |
| Lanadelumab | warnings and precautions | none in the top 1,000 |
| Lebrikizumab | warnings and precautions | none in the top 1,000 |
| Leniolisib | warnings and precautions | none in the top 1,000 |
| Levocarnitine | warnings (intravenous label) | none in the top 1,000 |
| Magnesium sulfate, polyethylene glycol 3350 and 3 other ingredients | warnings and precautions | none in the top 1,000 |
| Mesna | warnings and precautions (oral label) | none in the top 1,000 |
| Ofloxacin | precautions | none in the top 1,000 |
| Onasemnogene abeparvovec | warnings and precautions | none in the top 1,000 |
| Pegvisomant | warnings and precautions | none in the top 1,000 |
| Phenobarbital | warnings and precautions (intravenous label) | none in the top 1,000 |
| Procainamide | precautions | none in the top 1,000 |
| Remestemcel-l-rknd | warnings and precautions | none in the top 1,000 |
| Rimabotulinumtoxinb | warnings and precautions | none in the top 1,000 |
| Selpercatinib | warnings and precautions | none in the top 1,000 |
| Sirolimus | warnings and precautions (topical label) | none in the top 1,000 |
| Sodium phosphate dibasic and sodium phosphate monobasic | warnings and precautions (oral label) | none in the top 1,000 |
| Spesolimab | warnings and precautions (subcutaneous label) | none in the top 1,000 |
| Succimer | warnings and precautions (intravenous label) | none in the top 1,000 |
| Sulfacetamide | precautions (topical label) | none in the top 1,000 |
| Sulfur hexafluoride | warnings and precautions | none in the top 1,000 |
| Tarlatamab-dlle | warnings and precautions | none in the top 1,000 |
| Tazarotene | warnings and precautions (topical label) | none in the top 1,000 |
| Temsirolimus | warnings and precautions (intravenous label) | none in the top 1,000 |
| Tenecteplase | warnings and precautions | none in the top 1,000 |
| Terbutaline | precautions | none in the top 1,000 |
| Thrombin topical recombinant | warnings and precautions | none in the top 1,000 |
| Tildrakizumab | warnings and precautions | none in the top 1,000 |
| Tilmanocept | warnings and precautions | none in the top 1,000 |
| Trientine | precautions | none in the top 1,000 |
| Triptorelin | warnings and precautions | none in the top 1,000 |
| Ubrogepant | warnings and precautions | none in the top 1,000 |
| Etanercept | adverse reactions | 14,142 |
| Adalimumab | adverse reactions | 13,415 |
| Infliximab | adverse reactions | 10,283 |
| Tocilizumab | adverse reactions | 10,207 |
| Abatacept | adverse reactions | 9,638 |
| Certolizumab | adverse reactions | 8,305 |
| Tofacitinib | adverse reactions | 8,133 |
| Sulfasalazine | adverse reactions | 7,607 |
| Alendronate | adverse reactions | 6,789 |
| Dupilumab | adverse reactions | 5,583 |
| Secukinumab | adverse reactions | 5,112 |
| Oxycodone | adverse reactions | 4,681 |
| Ustekinumab | adverse reactions | 4,642 |
| Levothyroxine | adverse reactions | 4,416 |
Source: FDA drug labels via openFDA, read October 8, 2026; FAERS via openFDA, reports through July 30, 2026
Which of them have the most hypersensitivity reports in FAERS?
Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026; MedDRA preferred term “Hypersensitivity”
What next?
- Side effects across medicines
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