Side effects across medicines
Medicines whose labels list headache
1,427 medicines have an FDA label that names headache in its boxed warning, warnings, adverse reactions, trial table, patient leaflet or Drug Facts “stop use” warning (of the labels PlainMeds reads: each medicine's quoted label and up to eight more, by route and wording). Among them, the most FAERS reports of headache name adalimumab (28,765), etanercept (24,918) and methotrexate (23,243), through July 30, 2026. A label lists what its studies and reports found, and a report does not show that a medicine caused the event.
Check it at the source: the FDA FAERS public dashboard; FDA labels on DailyMed.
Which medicines' labels list headache?
Ordered by where the label names it, the boxed warning first, then by FAERS reports. The first 150 of the 1,427 are below; every other one is on its medicine record. A medicine whose own indications name it, because it treats it, is not counted.
| Medicine | Where a label names it | FAERS reports of headache |
|---|---|---|
| Methotrexate | warnings and precautions (intra-arterial/ | 23,243 |
| Levonorgestrel | warnings and precautions (intrauterine label) | 6,450 |
| Potassium chloride | warnings (intravenous label) | 5,080 |
| Ciprofloxacin | warnings and precautions (intravenous label) | 4,090 |
| Clonidine | warnings (transdermal label) | 2,919 |
| Metronidazole | precautions | 2,868 |
| Nitroglycerin | warnings and precautions (rectal label) | 2,681 |
| Tacrolimus | warnings and precautions (intravenous/ | 2,580 |
| Bevacizumab | warnings and precautions (intravascular label) | 2,360 |
| Levofloxacin | warnings and precautions (intravenous label) | 1,549 |
| Moxifloxacin | warnings and precautions (intravenous label) | 1,215 |
| Isosorbide mononitrate | precautions | 1,077 |
| Isosorbide dinitrate | precautions | 1,024 |
| Elexacaftor and ivacaftor and tezacaftor | warnings and precautions | 767 |
| Ketoconazole | precautions (oral label) | 754 |
| Buspirone | precautions | 731 |
| Valproic acid | warnings and precautions (intravenous label) | 429 |
| Theophylline | precautions | 402 |
| Blinatumomab | warnings and precautions | 370 |
| Cefdinir | precautions | 332 |
| Methimazole | precautions | 330 |
| Ofloxacin | precautions (oral label) | 283 |
| Alpha-tocopherol, ascorbic acid and 11 other ingredients | warnings and precautions | none in the top 1,000 |
| Alpha-tocopherol, ascorbic acid and 11 other ingredients | warnings and precautions | none in the top 1,000 |
| Amphetamine | precautions | none in the top 1,000 |
| Atezolizumab and hyaluronidase | warnings and precautions | none in the top 1,000 |
| Avelumab | warnings and precautions | none in the top 1,000 |
| Benzocaine | warnings (dental/ | none in the top 1,000 |
| Calcium chloride and potassium chloride and sodium chloride | warnings and precautions (intravenous label) | none in the top 1,000 |
| Camphor | warnings (respiratory (inhalation) label) | none in the top 1,000 |
| Cefotetan | precautions | none in the top 1,000 |
| Clomipramine | precautions | none in the top 1,000 |
| Cosibelimab | warnings and precautions | none in the top 1,000 |
| Cysteamine | warnings and precautions (oral label) | none in the top 1,000 |
| Daratumumab | warnings and precautions | none in the top 1,000 |
| Dextroamphetamine | precautions | none in the top 1,000 |
| Diatrizoate | precautions | none in the top 1,000 |
| Ethinyl estradiol and ethynodiol | warnings and precautions | none in the top 1,000 |
| Ethinyl estradiol and levonorgestrel | precautions | none in the top 1,000 |
| Ethinyl estradiol and segesterone | warnings and precautions | none in the top 1,000 |
| Hyaluronidase and ocrelizumab | warnings and precautions | none in the top 1,000 |
| Ivacaftor and tezacaftor | warnings and precautions | none in the top 1,000 |
| Mogamulizumab | warnings and precautions | none in the top 1,000 |
| Mosunetuzumab | warnings and precautions (intravenous label) | none in the top 1,000 |
| Multiple vitamins | warnings and precautions | none in the top 1,000 |
| Nafarelin | precautions | none in the top 1,000 |
| Nefazodone | precautions | none in the top 1,000 |
| Obinutuzumab | warnings and precautions | none in the top 1,000 |
| Propylthiouracil | precautions | none in the top 1,000 |
| Retifanlimab | warnings and precautions | none in the top 1,000 |
| Rifampin | precautions | none in the top 1,000 |
| Selegiline | precautions | none in the top 1,000 |
| Teprotumumab | warnings and precautions | none in the top 1,000 |
| Trandolapril and verapamil | precautions | none in the top 1,000 |
| Trastuzumab-strf | warnings and precautions | none in the top 1,000 |
| Verapamil | precautions | none in the top 1,000 |
| Zafirlukast | precautions | none in the top 1,000 |
| Adalimumab | adverse reactions | 28,765 |
| Etanercept | adverse reactions | 24,918 |
| Omeprazole | adverse reactions | 19,303 |
| Levothyroxine | adverse reactions | 18,590 |
| Gabapentin | adverse reactions | 17,924 |
| Apremilast | adverse reactions | 17,913 |
| Treprostinil | adverse reactions | 17,283 |
| Albuterol | adverse reactions (oral label) | 15,500 |
| Diphenhydramine | adverse reactions | 13,710 |
| Tofacitinib | adverse reactions | 13,624 |
| Furosemide | adverse reactions | 13,590 |
| Pantoprazole | adverse reactions | 13,325 |
| Pregabalin | adverse reactions | 13,068 |
| Lisinopril | adverse reactions | 13,015 |
| Infliximab | adverse reactions | 11,201 |
| Tadalafil | adverse reactions | 11,025 |
| Sildenafil | adverse reactions | 10,219 |
| Alprazolam | adverse reactions | 10,116 |
| Natalizumab | adverse reactions | 9,977 |
| Rituximab | adverse reactions | 9,926 |
| Metoprolol | adverse reactions | 9,797 |
| Tocilizumab | adverse reactions | 9,649 |
| Esomeprazole | adverse reactions (intravenous label) | 9,569 |
| Abatacept | adverse reactions | 9,517 |
| Dupilumab | adverse reactions | 9,307 |
| Leflunomide | adverse reactions | 9,224 |
| Simvastatin | adverse reactions | 8,998 |
| Lorazepam | adverse reactions | 8,906 |
| Interferon beta 1a | adverse reactions | 8,413 |
| Fluticasone | adverse reactions (respiratory (inhalation) label) | 8,348 |
| Losartan | adverse reactions | 8,330 |
| Macitentan | adverse reactions | 8,323 |
| Hydroxychloroquine | adverse reactions | 8,320 |
| Diclofenac | adverse reactions (oral label) | 8,315 |
| Montelukast | adverse reactions | 8,235 |
| Hydrochlorothiazide | adverse reactions | 7,779 |
| Celecoxib | adverse reactions | 7,507 |
| Venlafaxine | adverse reactions | 7,506 |
| Oxycodone | adverse reactions | 7,412 |
| Escitalopram | adverse reactions | 7,397 |
| Methylprednisolone | adverse reactions | 7,361 |
| Secukinumab | adverse reactions | 7,264 |
| Fingolimod | adverse reactions | 7,260 |
| Alendronate | adverse reactions | 7,181 |
| Certolizumab | adverse reactions | 7,099 |
| Sulfasalazine | adverse reactions | 7,016 |
| Quetiapine | adverse reactions | 6,988 |
| Bupropion | adverse reactions | 6,979 |
| Citalopram | adverse reactions | 6,792 |
| Sertraline | adverse reactions | 6,789 |
| Selexipag | adverse reactions | 6,740 |
| Fluoxetine | adverse reactions | 6,378 |
| Zolpidem | adverse reactions | 6,331 |
| Spironolactone | adverse reactions | 6,229 |
| Atenolol | adverse reactions | 5,960 |
| Lamotrigine | adverse reactions | 5,773 |
| Ondansetron | adverse reactions | 5,638 |
| Ramipril | adverse reactions | 5,628 |
| Clopidogrel | adverse reactions | 5,605 |
| Teriparatide | adverse reactions | 5,507 |
| Insulin glargine | adverse reactions | 5,491 |
| Omalizumab | adverse reactions | 5,455 |
| Ustekinumab | adverse reactions | 5,281 |
| Abaloparatide | adverse reactions | 5,123 |
| Diazepam | adverse reactions | 5,070 |
| Estradiol | adverse reactions (oral label) | 5,025 |
| Ribavirin | adverse reactions | 4,795 |
| Prednisolone | adverse reactions | 4,664 |
| Ofatumumab | adverse reactions | 4,633 |
| Valsartan | adverse reactions | 4,611 |
| Budesonide and formoterol | adverse reactions | 4,580 |
| Riociguat | adverse reactions | 4,513 |
| Baclofen | adverse reactions | 4,461 |
| Bisoprolol | adverse reactions | 4,461 |
| Peginterferon alfa 2a | adverse reactions | 4,455 |
| Epinephrine | adverse reactions | 4,392 |
| Carvedilol | adverse reactions | 4,370 |
| Lenalidomide | adverse reactions | 4,255 |
| Varenicline | adverse reactions | 4,149 |
| Vedolizumab | adverse reactions | 4,117 |
| Adalimumab-aaty | adverse reactions | 4,084 |
| Adalimumab-fkjp | adverse reactions | 4,025 |
| Allopurinol | adverse reactions | 4,007 |
| Mycophenolate mofetil | adverse reactions | 3,990 |
| Ranitidine | adverse reactions | 3,959 |
| Tiotropium | adverse reactions | 3,924 |
| Duloxetine | adverse reactions | 3,913 |
| Levetiracetam | adverse reactions | 3,732 |
| Cyclosporine | adverse reactions | 3,717 |
| Ledipasvir and sofosbuvir | adverse reactions | 3,707 |
| Denosumab | adverse reactions | 3,706 |
| Fluticasone and salmeterol | adverse reactions | 3,612 |
| Rosuvastatin | adverse reactions | 3,579 |
Source: FDA drug labels via openFDA, read October 8, 2026; FAERS via openFDA, reports through July 30, 2026
Which of them have the most headache reports in FAERS?
Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026; MedDRA preferred term “Headache”
What next?
- Side effects across medicines
- every reaction on PlainMeds
- Report a side effect to the FDA
- MedWatch