Side effects across medicines
Medicines whose labels list joint swelling
35 medicines have an FDA label that names joint swelling in its boxed warning, warnings, adverse reactions, trial table, patient leaflet or Drug Facts “stop use” warning (of the labels PlainMeds reads: each medicine's quoted label and up to eight more, by route and wording). Among them, the most FAERS reports of joint swelling name tofacitinib (14,712), alendronate (7,205) and pregabalin (5,027), through July 30, 2026. A label lists what its studies and reports found, and a report does not show that a medicine caused the event.
Check it at the source: the FDA FAERS public dashboard; FDA labels on DailyMed.
Which medicines' labels list joint swelling?
Ordered by where the label names it, the boxed warning first, then by FAERS reports. A medicine whose own indications name it, because it treats it, is not counted.
| Medicine | Where a label names it | FAERS reports of joint swelling |
|---|---|---|
| Tofacitinib | adverse reactions | 14,712 |
| Alendronate | adverse reactions | 7,205 |
| Pregabalin | adverse reactions | 5,027 |
| Atorvastatin | adverse reactions | 2,327 |
| Minocycline | adverse reactions | 857 |
| Buprenorphine | adverse reactions (transdermal label) | 769 |
| Tiotropium | adverse reactions | 739 |
| Zoledronic acid | adverse reactions | 583 |
| Natalizumab | adverse reactions | 478 |
| Febuxostat | adverse reactions | 191 |
| Abiraterone | adverse reactions | 190 |
| Risperidone | adverse reactions | 183 |
| Nilotinib | adverse reactions | 90 |
| Siponimod | adverse reactions | 88 |
| Lubiprostone | adverse reactions | 70 |
| Pegvaliase | adverse reactions | 69 |
| Amlodipine and atorvastatin | adverse reactions | 55 |
| Alendronate and cholecalciferol | adverse reactions | 53 |
| Amlodipine and hydrochlorothiazide and olmesartan | adverse reactions | none in the top 1,000 |
| Avutometinib and defactinib | adverse reactions | none in the top 1,000 |
| Cedazuridine and decitabine | adverse reactions | none in the top 1,000 |
| Cromolyn | adverse reactions (intrabronchial label) | none in the top 1,000 |
| Danazol | adverse reactions | none in the top 1,000 |
| Esomeprazole and naproxen | adverse reactions | none in the top 1,000 |
| Fluoxetine and olanzapine | adverse reactions | none in the top 1,000 |
| Ivosidenib | adverse reactions | none in the top 1,000 |
| Methyldopa | adverse reactions | none in the top 1,000 |
| Mitapivat | adverse reactions | none in the top 1,000 |
| Olodaterol and tiotropium | adverse reactions | none in the top 1,000 |
| Olutasidenib | adverse reactions | none in the top 1,000 |
| Ponatinib | adverse reactions | none in the top 1,000 |
| Ponesimod | adverse reactions | none in the top 1,000 |
| Tesamorelin | adverse reactions | none in the top 1,000 |
| Tiopronin | adverse reactions | none in the top 1,000 |
| Velmanase alfa-tycv | adverse reactions | none in the top 1,000 |
Source: FDA drug labels via openFDA, read October 8, 2026; FAERS via openFDA, reports through July 30, 2026
Which of them have the most joint swelling reports in FAERS?
Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026; MedDRA preferred term “Joint Swelling”
What next?
- Side effects across medicines
- every reaction on PlainMeds
- Report a side effect to the FDA
- MedWatch