Side effects across medicines
Medicines whose labels list numbness
419 medicines have an FDA label that names numbness (hypoesthesia) in its boxed warning, warnings, adverse reactions, trial table, patient leaflet or Drug Facts “stop use” warning (of the labels PlainMeds reads: each medicine's quoted label and up to eight more, by route and wording). Among them, the most FAERS reports of numbness name adalimumab (10,633), etanercept (7,865) and pregabalin (6,448), through July 30, 2026. A label lists what its studies and reports found, and a report does not show that a medicine caused the event.
Check it at the source: the FDA FAERS public dashboard; FDA labels on DailyMed.
Which medicines' labels list numbness?
Ordered by where the label names it, the boxed warning first, then by FAERS reports. The first 152 of the 419 are below; every other one is on its medicine record. A medicine whose own indications name it, because it treats it, is not counted.
| Medicine | Where a label names it | FAERS reports of numbness |
|---|---|---|
| Ciprofloxacin | warnings and precautions (intravenous label) | 2,223 |
| Metronidazole | warnings and precautions (vaginal label) | 931 |
| Levofloxacin | warnings and precautions (intravenous label) | 755 |
| Sumatriptan | warnings and precautions (nasal label) | 669 |
| Amphetamine and dextroamphetamine | precautions | 621 |
| Moxifloxacin | warnings and precautions (intravenous label) | 448 |
| Benzonatate | precautions | 188 |
| Ofloxacin | warnings (oral label) | 87 |
| Amphetamine | precautions | none in the top 1,000 |
| Cabotegravir and rilpivirine | warnings and precautions | none in the top 1,000 |
| Caffeine and ergotamine | precautions | none in the top 1,000 |
| Dextroamphetamine | precautions | none in the top 1,000 |
| Dihydroergotamine | warnings (intramuscular/ | none in the top 1,000 |
| Ergotamine | precautions | none in the top 1,000 |
| Foscarnet | precautions | none in the top 1,000 |
| Hydralazine | precautions | none in the top 1,000 |
| Onasemnogene abeparvovec | warnings and precautions (intrathecal label) | none in the top 1,000 |
| Pregabalin | adverse reactions | 6,448 |
| Celecoxib | adverse reactions | 4,278 |
| Lenalidomide | adverse reactions | 3,744 |
| Oxycodone | adverse reactions | 3,608 |
| Quetiapine | adverse reactions | 2,927 |
| Amlodipine | adverse reactions | 2,558 |
| Topiramate | adverse reactions | 2,374 |
| Clonazepam | adverse reactions | 2,340 |
| Lamotrigine | adverse reactions | 1,965 |
| Zolpidem | adverse reactions | 1,789 |
| Citalopram | adverse reactions | 1,775 |
| Escitalopram | adverse reactions | 1,715 |
| Fluticasone | adverse reactions (topical label) | 1,699 |
| Sertraline | adverse reactions | 1,588 |
| Montelukast | adverse reactions | 1,547 |
| Tramadol | adverse reactions | 1,471 |
| Bupropion | adverse reactions | 1,410 |
| Carvedilol | adverse reactions | 1,296 |
| Capecitabine | adverse reactions | 1,265 |
| Chlorhexidine | adverse reactions (dental label) | 1,133 |
| Bisoprolol | adverse reactions | 1,113 |
| Buprenorphine | adverse reactions | 1,107 |
| Omalizumab | adverse reactions | 991 |
| Duloxetine | adverse reactions | 959 |
| Mirtazapine | adverse reactions | 936 |
| Bortezomib | adverse reactions | 924 |
| Etonogestrel | adverse reactions | 799 |
| Fentanyl | adverse reactions (transdermal label) | 779 |
| Sildenafil | adverse reactions | 770 |
| Letrozole | adverse reactions | 764 |
| Cyclophosphamide | adverse reactions | 758 |
| Clonidine | adverse reactions (transdermal label) | 716 |
| Atomoxetine | adverse reactions | 712 |
| Cyclosporine | adverse reactions | 661 |
| Epinephrine | adverse reactions (intramuscular/ | 643 |
| Enzalutamide | adverse reactions | 630 |
| Paroxetine | adverse reactions | 605 |
| Tadalafil | adverse reactions | 594 |
| Ciprofloxacin and hydrocortisone | adverse reactions | 587 |
| Minocycline | adverse reactions | 571 |
| Leuprolide | adverse reactions | 557 |
| Risperidone | adverse reactions | 545 |
| Zoledronic acid | adverse reactions | 528 |
| Thalidomide | adverse reactions | 494 |
| Acetaminophen and oxycodone | adverse reactions | 375 |
| Nifedipine | adverse reactions | 365 |
| Oxcarbazepine | adverse reactions | 340 |
| Carbidopa and levodopa | adverse reactions | 326 |
| Doxazosin | adverse reactions | 325 |
| Exemestane | adverse reactions | 293 |
| Nilotinib | adverse reactions | 289 |
| Trazodone | adverse reactions | 280 |
| Filgrastim | adverse reactions | 265 |
| Eszopiclone | adverse reactions | 259 |
| Human immunoglobulin g | adverse reactions | 245 |
| Amitriptyline | adverse reactions | 238 |
| Pramipexole | adverse reactions | 236 |
| Telmisartan | adverse reactions | 234 |
| Doxepin | adverse reactions | 223 |
| Ropinirole | adverse reactions | 219 |
| Acetaminophen and butalbital and caffeine | adverse reactions | 218 |
| Lacosamide | adverse reactions | 209 |
| Gemfibrozil | adverse reactions | 206 |
| Buprenorphine and naloxone | adverse reactions | 198 |
| Atropine and diphenoxylate | adverse reactions | 192 |
| Diclofenac and misoprostol | adverse reactions | 185 |
| Rizatriptan | adverse reactions | 185 |
| Indapamide | adverse reactions | 183 |
| Isosorbide mononitrate | adverse reactions | 159 |
| Milnacipran | adverse reactions | 158 |
| Raloxifene | adverse reactions | 155 |
| Gadoxetate | adverse reactions | 153 |
| Amifampridine | adverse reactions | 143 |
| Phentermine and topiramate | adverse reactions | 140 |
| Somatropin | adverse reactions | 140 |
| Buspirone | adverse reactions | 131 |
| Asenapine | adverse reactions | 125 |
| Atezolizumab | adverse reactions | 122 |
| Febuxostat | adverse reactions | 121 |
| Labetalol | adverse reactions (intravenous label) | 121 |
| Tapentadol | adverse reactions | 115 |
| Nortriptyline | adverse reactions | 112 |
| Agalsidase beta | adverse reactions | 108 |
| Carfilzomib | adverse reactions | 106 |
| Epoprostenol | adverse reactions | 103 |
| Itraconazole | adverse reactions | 98 |
| Pitavastatin | adverse reactions | 97 |
| Gentamicin | adverse reactions (intramuscular/ | 96 |
| Asfotase alfa | adverse reactions | 92 |
| Gadoteridol | adverse reactions | 91 |
| Fesoterodine | adverse reactions | 90 |
| Paricalcitol | adverse reactions (intravenous label) | 89 |
| Amiodarone | adverse reactions (intravenous label) | 88 |
| Lorlatinib | adverse reactions | 88 |
| Crizotinib | adverse reactions | 84 |
| Ziconotide | adverse reactions | 83 |
| Dichlorphenamide | adverse reactions | 81 |
| Ferric carboxymaltose | adverse reactions | 81 |
| Iopromide | adverse reactions | 81 |
| Iohexol | adverse reactions | 79 |
| Ropivacaine | adverse reactions | 74 |
| Acebutolol | adverse reactions | none in the top 1,000 |
| Acetaminophen and benzhydrocodone | adverse reactions | none in the top 1,000 |
| Acetaminophen and butalbital | adverse reactions | none in the top 1,000 |
| Acetaminophen, butalbital, caffeine and codeine | adverse reactions | none in the top 1,000 |
| Acetazolamide | adverse reactions | none in the top 1,000 |
| Acitretin | adverse reactions | none in the top 1,000 |
| Almotriptan | adverse reactions | none in the top 1,000 |
| Alosetron | adverse reactions | none in the top 1,000 |
| Amiloride and hydrochlorothiazide | adverse reactions | none in the top 1,000 |
| Aminolevulinic acid | adverse reactions | none in the top 1,000 |
| Amitriptyline and chlordiazepoxide | adverse reactions | none in the top 1,000 |
| Amitriptyline and perphenazine | adverse reactions | none in the top 1,000 |
| Amlodipine and atorvastatin | adverse reactions | none in the top 1,000 |
| Amlodipine and benazepril | adverse reactions | none in the top 1,000 |
| Amlodipine and telmisartan | adverse reactions | none in the top 1,000 |
| Amoxapine | adverse reactions | none in the top 1,000 |
| Amoxicillin and clarithromycin and lansoprazole | adverse reactions | none in the top 1,000 |
| Anagrelide | adverse reactions | none in the top 1,000 |
| Apraclonidine | adverse reactions | none in the top 1,000 |
| Arginine | adverse reactions | none in the top 1,000 |
| Artemether and lumefantrine | adverse reactions | none in the top 1,000 |
| Articaine and epinephrine | adverse reactions | none in the top 1,000 |
| Aspirin, butalbital, caffeine and codeine | adverse reactions | none in the top 1,000 |
| Atezolizumab and hyaluronidase | adverse reactions | none in the top 1,000 |
| Atropine and difenoxin | adverse reactions | none in the top 1,000 |
| Basiliximab | adverse reactions | none in the top 1,000 |
| Benazepril and hydrochlorothiazide | adverse reactions | none in the top 1,000 |
| Benznidazole | adverse reactions | none in the top 1,000 |
| Benztropine | adverse reactions | none in the top 1,000 |
| Berahyaluronidase alfa and pembrolizumab | adverse reactions | none in the top 1,000 |
| Betaxolol | adverse reactions | none in the top 1,000 |
| Bexarotene | adverse reactions | none in the top 1,000 |
| Adalimumab | patient leaflet | 10,633 |
| Etanercept | patient leaflet | 7,865 |
Source: FDA drug labels via openFDA, read October 8, 2026; FAERS via openFDA, reports through July 30, 2026
Which of them have the most numbness reports in FAERS?
Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026; MedDRA preferred term “Hypoaesthesia”
What next?
- Side effects across medicines
- every reaction on PlainMeds
- Report a side effect to the FDA
- MedWatch