Side effects across medicines

Medicines whose labels list insomnia

652 medicines have an FDA label that names insomnia in its boxed warning, warnings, adverse reactions, trial table, patient leaflet or Drug Facts “stop use” warning (of the labels PlainMeds reads: each medicine's quoted label and up to eight more, by route and wording). Among them, the most FAERS reports of insomnia name acetaminophen (10,812), pregabalin (9,729) and gabapentin (9,583), through July 30, 2026. A label lists what its studies and reports found, and a report does not show that a medicine caused the event.

Check it at the source: the FDA FAERS public dashboard; FDA labels on DailyMed.

Which medicines' labels list insomnia?

Ordered by where the label names it, the boxed warning first, then by FAERS reports. The first 151 of the 652 are below; every other one is on its medicine record. A medicine whose own indications name it, because it treats it, is not counted.

Medicine	Where a label names it	FAERS reports of insomnia
Ciprofloxacin	warnings and precautions (intravenous label)	2,517
Levofloxacin	warnings and precautions (intravenous label)	1,081
Metoclopramide	warnings and precautions (nasal label)	1,074
Moxifloxacin	warnings and precautions (intravenous label)	351
Theophylline	precautions	263
Ofloxacin	warnings (oral label)	146
Aminophylline	precautions	none in the top 1,000
Mosunetuzumab	warnings and precautions (intravenous label)	none in the top 1,000
Viloxazine	warnings and precautions	none in the top 1,000
Zafirlukast	precautions	none in the top 1,000
Pregabalin	adverse reactions	9,729
Gabapentin	adverse reactions	9,583
Levothyroxine	adverse reactions	9,117
Omeprazole	adverse reactions	8,990
Alprazolam	adverse reactions	7,287
Clonazepam	adverse reactions	7,120
Lorazepam	adverse reactions	6,416
Pantoprazole	adverse reactions	5,758
Varenicline	adverse reactions	5,574
Simvastatin	adverse reactions	5,300
Atorvastatin	adverse reactions	5,102
Metoprolol	adverse reactions	4,929
Oxycodone	adverse reactions	4,924
Venlafaxine	adverse reactions	4,866
Diphenhydramine	adverse reactions	4,570
Celecoxib	adverse reactions	4,547
Bupropion	adverse reactions	4,513
Amlodipine	adverse reactions	4,494
Escitalopram	adverse reactions	4,491
Sertraline	adverse reactions	4,466
Fluoxetine	adverse reactions	4,222
Dupilumab	adverse reactions	4,193
Tofacitinib	adverse reactions	4,174
Lenalidomide	adverse reactions	4,168
Diclofenac	adverse reactions (oral label)	3,955
Diazepam	adverse reactions	3,944
Aripiprazole	adverse reactions	3,934
Lamotrigine	adverse reactions	3,856
Montelukast	adverse reactions	3,736
Citalopram	adverse reactions	3,651
Ribavirin	adverse reactions	3,435
Hydroxychloroquine	adverse reactions	3,411
Apremilast	adverse reactions	3,363
Sulfasalazine	adverse reactions	3,359
Dalfampridine	adverse reactions	3,306
Peginterferon alfa 2a	adverse reactions	3,079
Olanzapine	adverse reactions	2,871
Niraparib	adverse reactions	2,841
Risperidone	adverse reactions	2,773
Topiramate	adverse reactions	2,773
Baclofen	adverse reactions	2,695
Ramipril	adverse reactions	2,585
Estradiol	adverse reactions	2,480
Carvedilol	adverse reactions	2,267
Propranolol	adverse reactions	2,247
Bisoprolol	adverse reactions	2,185
Methylphenidate	adverse reactions	2,153
Teriparatide	adverse reactions	2,027
Levetiracetam	adverse reactions	2,001
Tiotropium	adverse reactions	1,920
Allopurinol	adverse reactions	1,903
Doxycycline	adverse reactions (intravenous label)	1,853
Duloxetine	adverse reactions	1,793
Sildenafil	adverse reactions	1,721
Ranitidine	adverse reactions	1,703
Mycophenolate mofetil	adverse reactions	1,656
Sulfamethoxazole and trimethoprim	adverse reactions	1,654
Morphine	adverse reactions	1,604
Tadalafil	adverse reactions	1,585
Desvenlafaxine	adverse reactions	1,574
Divalproex	adverse reactions	1,555
Fentanyl	adverse reactions (transdermal label)	1,536
Rivaroxaban	adverse reactions	1,512
Tramadol	adverse reactions	1,511
Rosuvastatin	adverse reactions	1,500
Lisdexamfetamine	adverse reactions	1,488
Letrozole	adverse reactions	1,470
Buprenorphine	adverse reactions	1,435
Hydromorphone	adverse reactions	1,425
Amoxicillin	adverse reactions	1,416
Paroxetine	adverse reactions	1,396
Carbidopa and levodopa	adverse reactions	1,380
Enzalutamide	adverse reactions	1,362
Estrogens conjugated	adverse reactions	1,348
Clonidine	adverse reactions	1,326
Cyclobenzaprine	adverse reactions	1,322
Anastrozole	adverse reactions	1,297
Cyclosporine	adverse reactions	1,285
Atomoxetine	adverse reactions	1,261
Leuprolide	adverse reactions	1,220
Diltiazem	adverse reactions	1,219
Risedronate	adverse reactions	1,214
Budesonide	adverse reactions (oral label)	1,210
Mirabegron	adverse reactions	1,162
Naltrexone	adverse reactions	1,153
Modafinil	adverse reactions	1,148
Buprenorphine and naloxone	adverse reactions	1,081
Sofosbuvir	adverse reactions	1,061
Azithromycin	adverse reactions	1,039
Pirfenidone	adverse reactions	1,028
Lurasidone	adverse reactions	1,014
Donepezil	adverse reactions	1,007
Armodafinil	adverse reactions	976
Metronidazole	adverse reactions	959
Bortezomib	adverse reactions	870
Ipratropium	adverse reactions (respiratory (inhalation) label)	860
Ruxolitinib	adverse reactions (topical label)	851
Clarithromycin	adverse reactions	844
Ledipasvir and sofosbuvir	adverse reactions	835
Relugolix	adverse reactions	835
Amitriptyline	adverse reactions	825
Fluconazole	adverse reactions	823
Exemestane	adverse reactions	796
Progesterone	adverse reactions (intramuscular label)	785
Clozapine	adverse reactions	774
Zoledronic acid	adverse reactions	768
Enalapril	adverse reactions	762
Oxcarbazepine	adverse reactions	759
Acetaminophen and codeine	adverse reactions	749
Tacrolimus	adverse reactions	742
Ibrutinib	adverse reactions	723
Trazodone	adverse reactions	694
Pomalidomide	adverse reactions	688
Dexlansoprazole	adverse reactions	686
Trastuzumab	adverse reactions	674
Capecitabine	adverse reactions	663
Methadone	adverse reactions	656
Abaloparatide	adverse reactions	654
Isosorbide mononitrate	adverse reactions	651
Nebivolol	adverse reactions	651
Nifedipine	adverse reactions	636
Paliperidone	adverse reactions	632
Lovastatin	adverse reactions	625
Methocarbamol	adverse reactions	625
Vilazodone	adverse reactions	617
Ribociclib	adverse reactions	603
Alemtuzumab	adverse reactions	588
Lacosamide	adverse reactions	587
Pramipexole	adverse reactions	584
Tamsulosin	adverse reactions	574
Valbenazine	adverse reactions	573
Amantadine	adverse reactions	569
Felodipine	adverse reactions	565
Acetaminophen and oxycodone	adverse reactions	558
Telmisartan	adverse reactions	551
Testosterone	adverse reactions (subcutaneous label)	549
Oxybutynin	adverse reactions	542
Promethazine	adverse reactions	537
Indomethacin	adverse reactions	532
Fulvestrant	adverse reactions	525
Acetaminophen	trial table	10,812

Source: FDA drug labels via openFDA, read October 8, 2026; FAERS via openFDA, reports through July 30, 2026

Which of them have the most insomnia reports in FAERS?

Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.

Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026; MedDRA preferred term “Insomnia”

What next?

Side effects across medicines: every reaction on PlainMeds
Report a side effect to the FDA: MedWatch