Side effects across medicines

Medicines whose labels list dry mouth

485 medicines have an FDA label that names dry mouth in its boxed warning, warnings, adverse reactions, trial table, patient leaflet or Drug Facts “stop use” warning (of the labels PlainMeds reads: each medicine's quoted label and up to eight more, by route and wording). Among them, the most FAERS reports of dry mouth name pregabalin (3,765), omeprazole (3,472) and gabapentin (3,100), through July 30, 2026. A label lists what its studies and reports found, and a report does not show that a medicine caused the event.

Check it at the source: the FDA FAERS public dashboard; FDA labels on DailyMed.

Which medicines' labels list dry mouth?

Ordered by where the label names it, the boxed warning first, then by FAERS reports. The first 150 of the 485 are below; every other one is on its medicine record. A medicine whose own indications name it, because it treats it, is not counted.

Medicine	Where a label names it	FAERS reports of dry mouth
Oxybutynin	warnings (transdermal label)	689
Doxepin	precautions	159
Amitriptyline and perphenazine	precautions	none in the top 1,000
Atenolol and chlorthalidone	precautions	none in the top 1,000
Pralidoxime	precautions	none in the top 1,000
Pregabalin	adverse reactions	3,765
Omeprazole	adverse reactions	3,472
Gabapentin	adverse reactions	3,100
Pantoprazole	adverse reactions	2,924
Diclofenac	adverse reactions (oral label)	2,870
Lisinopril	adverse reactions	2,835
Oxycodone	adverse reactions	2,775
Leflunomide	adverse reactions	2,758
Tiotropium	adverse reactions	2,562
Quetiapine	adverse reactions	2,509
Celecoxib	adverse reactions	2,493
Ramipril	adverse reactions	2,017
Amlodipine	adverse reactions	1,941
Metoprolol	adverse reactions	1,799
Alprazolam	adverse reactions	1,676
Esomeprazole	adverse reactions (intravenous label)	1,665
Clonazepam	adverse reactions	1,513
Mirabegron	adverse reactions	1,454
Lamotrigine	adverse reactions	1,440
Topiramate	adverse reactions	1,284
Atenolol	adverse reactions	1,234
Tramadol	adverse reactions	1,233
Venlafaxine	adverse reactions	1,230
Bupropion	adverse reactions	1,181
Zolpidem	adverse reactions	1,130
Escitalopram	adverse reactions	1,080
Citalopram	adverse reactions	1,077
Lenalidomide	adverse reactions	1,034
Sertraline	adverse reactions	1,008
Cabozantinib	adverse reactions	996
Fluoxetine	adverse reactions	995
Diazepam	adverse reactions	940
Buprenorphine	adverse reactions (transdermal label)	882
Niraparib	adverse reactions	852
Peginterferon alfa 2a	adverse reactions	838
Acetaminophen and codeine	adverse reactions	835
Chlorhexidine	adverse reactions (dental label)	831
Atomoxetine	adverse reactions	827
Fesoterodine	adverse reactions	823
Carvedilol	adverse reactions	796
Mirtazapine	adverse reactions	779
Ribavirin	adverse reactions	779
Botulinum toxin type a	adverse reactions	770
Bisoprolol	adverse reactions	760
Cyclobenzaprine	adverse reactions	729
Aripiprazole	adverse reactions	677
Duloxetine	adverse reactions	654
Olanzapine	adverse reactions	650
Pembrolizumab	adverse reactions	596
Baclofen	adverse reactions	593
Hydromorphone	adverse reactions	546
Sildenafil	adverse reactions	536
Sodium oxybate	adverse reactions	519
Varenicline	adverse reactions	511
Carbidopa and levodopa	adverse reactions	506
Fluticasone and salmeterol	adverse reactions	500
Risperidone	adverse reactions	499
Clonidine	adverse reactions	498
Ipratropium	adverse reactions	484
Piroxicam	adverse reactions	479
Sunitinib	adverse reactions	479
Letrozole	adverse reactions	469
Metronidazole	adverse reactions	459
Diltiazem	adverse reactions	449
Morphine	adverse reactions	443
Aprepitant	adverse reactions	439
Methylphenidate	adverse reactions	430
Amphetamine and dextroamphetamine	adverse reactions	429
Fentanyl	adverse reactions (transdermal label)	425
Tadalafil	adverse reactions	425
Dexlansoprazole	adverse reactions	419
Lisdexamfetamine	adverse reactions	408
Hydroxyzine	adverse reactions	387
Lenvatinib	adverse reactions	375
Everolimus	adverse reactions	371
Capecitabine	adverse reactions	364
Interferon beta 1a	adverse reactions	356
Anastrozole	adverse reactions	354
Desvenlafaxine	adverse reactions	343
Amantadine	adverse reactions	323
Fluconazole	adverse reactions	321
Enalapril	adverse reactions	320
Paroxetine	adverse reactions	319
Modafinil	adverse reactions	315
Temazepam	adverse reactions	304
Calcitriol	adverse reactions	297
Bupropion and naltrexone	adverse reactions	295
Divalproex	adverse reactions	274
Phentermine and topiramate	adverse reactions	273
Doxazosin	adverse reactions	267
Acetaminophen and oxycodone	adverse reactions	262
Carbamazepine	adverse reactions	262
Tolterodine	adverse reactions	262
Fulvestrant	adverse reactions	259
Moxifloxacin	adverse reactions	259
Armodafinil	adverse reactions	251
Sucralfate	adverse reactions	249
Eszopiclone	adverse reactions	247
Ribociclib	adverse reactions	247
Clarithromycin	adverse reactions	240
Glycopyrronium	adverse reactions	236
Nifedipine	adverse reactions	236
Valbenazine	adverse reactions	226
Tolvaptan	adverse reactions	213
Lovastatin	adverse reactions	211
Brimonidine	adverse reactions	207
Zoledronic acid	adverse reactions	207
Scopolamine	adverse reactions	205
Tizanidine	adverse reactions	200
Amitriptyline	adverse reactions	199
Prochlorperazine	adverse reactions (rectal label)	194
Rabeprazole	adverse reactions	190
Meclizine	adverse reactions	184
Lumateperone	adverse reactions	180
Amiodarone	adverse reactions	179
Tacrolimus	adverse reactions (topical label)	179
Oxaliplatin	adverse reactions	175
Sodium ferric gluconate complex	adverse reactions	174
Lithium	adverse reactions	173
Vortioxetine	adverse reactions	171
Umeclidinium and vilanterol	adverse reactions	165
Octreotide	adverse reactions (oral label)	164
Clozapine	adverse reactions	162
Calcium oxybate, magnesium oxybate, potassium oxybate and sodium oxybate	adverse reactions	161
Methadone	adverse reactions	161
Naltrexone	adverse reactions	159
Bumetanide	adverse reactions	154
Telmisartan	adverse reactions	154
Trazodone	adverse reactions	154
Canagliflozin	adverse reactions	151
Sorafenib	adverse reactions	150
Ropinirole	adverse reactions	149
Promethazine	adverse reactions	145
Vibegron	adverse reactions	140
Pramipexole	adverse reactions	135
Talquetamab	adverse reactions	133
Indapamide	adverse reactions	132
Mannitol	adverse reactions	132
Oxcarbazepine	adverse reactions	132
Rasagiline	adverse reactions	130
Trametinib	adverse reactions	129
Tapentadol	adverse reactions	125
Deutetrabenazine	adverse reactions	124
Lurasidone	adverse reactions	120
Tamsulosin	adverse reactions	119

Source: FDA drug labels via openFDA, read October 8, 2026; FAERS via openFDA, reports through July 30, 2026

Which of them have the most dry mouth reports in FAERS?

Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.

Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026; MedDRA preferred term “Dry Mouth”

What next?

Side effects across medicines: every reaction on PlainMeds
Report a side effect to the FDA: MedWatch