Side effects across medicines

Medicines whose labels list weight gain

376 medicines have an FDA label that names weight gain in its boxed warning, warnings, adverse reactions, trial table, patient leaflet or Drug Facts “stop use” warning (of the labels PlainMeds reads: each medicine's quoted label and up to eight more, by route and wording). Among them, the most FAERS reports of weight gain name methotrexate (11,971), pregabalin (11,621) and adalimumab (10,521), through July 30, 2026. A label lists what its studies and reports found, and a report does not show that a medicine caused the event.

Check it at the source: the FDA FAERS public dashboard; FDA labels on DailyMed.

Which medicines' labels list weight gain?

Ordered by where the label names it, the boxed warning first, then by FAERS reports. The first 152 of the 376 are below; every other one is on its medicine record. A medicine whose own indications name it, because it treats it, is not counted.

Medicine	Where a label names it	FAERS reports of weight gain
Furosemide	precautions	7,438
Olanzapine	warnings and precautions (intramuscular label)	6,833
Diclofenac	precautions (oral label)	5,366
Clonazepam	precautions	4,580
Bisoprolol	precautions	1,484
Medroxyprogesterone	warnings and precautions (subcutaneous label)	821
Asenapine	warnings and precautions (transdermal label)	564
Ziprasidone	warnings and precautions (intramuscular label)	279
Isosorbide mononitrate	precautions	215
Clomipramine	precautions	114
Nabumetone	precautions	103
Etodolac	precautions	97
Carbidopa	precautions	none in the top 1,000
Clomiphene	precautions	none in the top 1,000
Diflunisal	precautions	none in the top 1,000
Hydrocodone and ibuprofen	precautions	none in the top 1,000
Isradipine	precautions	none in the top 1,000
Ketorolac	precautions	none in the top 1,000
Meclofenamate	precautions	none in the top 1,000
Menotropins	warnings and precautions	none in the top 1,000
Methyldopa	precautions	none in the top 1,000
Rotigotine	warnings and precautions	none in the top 1,000
Sulindac	precautions	none in the top 1,000
Tiagabine	precautions	none in the top 1,000
Tolmetin	precautions	none in the top 1,000
Pregabalin	adverse reactions	11,621
Risperidone	adverse reactions	9,189
Quetiapine	adverse reactions	8,382
Aripiprazole	adverse reactions	7,849
Tocilizumab	adverse reactions	7,429
Gabapentin	adverse reactions	7,083
Rituximab	adverse reactions	6,782
Omeprazole	adverse reactions	6,026
Celecoxib	adverse reactions	4,249
Alprazolam	adverse reactions	4,162
Methylprednisolone	adverse reactions (intra-articular/intralesional/intramuscular/soft tissue label)	4,053
Insulin glargine	adverse reactions	3,859
Levonorgestrel	adverse reactions (intrauterine label)	3,854
Venlafaxine	adverse reactions	3,580
Amlodipine	adverse reactions	3,465
Escitalopram	adverse reactions	3,320
Lamotrigine	adverse reactions	3,191
Bupropion	adverse reactions	3,102
Ramipril	adverse reactions	3,094
Citalopram	adverse reactions	3,023
Dexamethasone	adverse reactions	2,471
Fluticasone	adverse reactions (respiratory (inhalation) label)	2,322
Cortisone	adverse reactions	2,319
Insulin lispro	adverse reactions	2,285
Carvedilol	adverse reactions	2,219
Divalproex	adverse reactions	2,168
Prednisolone	adverse reactions	2,040
Mirtazapine	adverse reactions	2,001
Ruxolitinib	adverse reactions	1,996
Varenicline	adverse reactions	1,976
Etonogestrel	adverse reactions	1,964
Leuprolide	adverse reactions	1,796
Estradiol	adverse reactions	1,795
Clozapine	adverse reactions	1,794
Brexpiprazole	adverse reactions	1,702
Paliperidone	adverse reactions	1,655
Fluticasone and salmeterol	adverse reactions	1,484
Duloxetine	adverse reactions	1,349
Triamcinolone	adverse reactions (intra-articular/intramuscular label)	1,336
Pioglitazone	adverse reactions	1,301
Insulin aspart	adverse reactions	1,271
Baclofen	adverse reactions	1,251
Cyclobenzaprine	adverse reactions	1,228
Haloperidol	adverse reactions (intramuscular label)	1,228
Lithium	adverse reactions	1,190
Natalizumab	adverse reactions	1,122
Paroxetine	adverse reactions	1,117
Lurasidone	adverse reactions	1,095
Clonidine	adverse reactions	1,067
Estrogens conjugated	adverse reactions	1,027
Diltiazem	adverse reactions	1,018
Upadacitinib	adverse reactions	1,009
Insulin human	adverse reactions	920
Letrozole	adverse reactions	920
Relugolix	adverse reactions	864
Anastrozole	adverse reactions	855
Tacrolimus	adverse reactions	841
Aprepitant	adverse reactions (intravenous label)	822
Mometasone	adverse reactions (topical label)	821
Oxcarbazepine	adverse reactions	768
Desvenlafaxine	adverse reactions	690
Drospirenone and ethinyl estradiol	adverse reactions	671
Lisdexamfetamine	adverse reactions	658
Glimepiride	adverse reactions	640
Dexlansoprazole	adverse reactions	599
Valproic acid	adverse reactions	598
Vortioxetine	adverse reactions	597
Insulin degludec	adverse reactions	568
Glyburide	adverse reactions	547
Progesterone	adverse reactions	536
Deflazacort	adverse reactions	531
Pomalidomide	adverse reactions	515
Cariprazine	adverse reactions	477
Glatiramer	adverse reactions	438
Ethinyl estradiol and etonogestrel	adverse reactions	418
Methadone	adverse reactions	416
Lorlatinib	adverse reactions	399
Eszopiclone	adverse reactions	372
Zoledronic acid	adverse reactions	370
Carbidopa and levodopa	adverse reactions	361
Imatinib	adverse reactions	354
Testosterone	adverse reactions (transdermal label)	353
Amitriptyline	adverse reactions	334
Naltrexone	adverse reactions	333
Nilotinib	adverse reactions	326
Trazodone	adverse reactions	319
Indomethacin	adverse reactions	315
Exemestane	adverse reactions	304
Vilazodone	adverse reactions	298
Buspirone	adverse reactions	292
Doxepin	adverse reactions	288
Pramipexole	adverse reactions	277
Tretinoin	adverse reactions (oral label)	255
Vamorolone	adverse reactions	254
Raloxifene	adverse reactions	242
Prochlorperazine	adverse reactions	233
Valbenazine	adverse reactions	222
Aripiprazole lauroxil	adverse reactions	215
Cholestyramine	adverse reactions	214
Linagliptin	adverse reactions	213
Loxapine	adverse reactions	209
Alectinib	adverse reactions	208
Guanfacine	adverse reactions	203
Insulin glulisine	adverse reactions	196
Baricitinib	adverse reactions	187
Hydrochlorothiazide and lisinopril	adverse reactions	178
Norethindrone	adverse reactions	178
Bicalutamide	adverse reactions	175
Goserelin	adverse reactions	173
Thalidomide	adverse reactions	173
Doxorubicin	adverse reactions	163
Zonisamide	adverse reactions	159
Canakinumab	adverse reactions	155
Lubiprostone	adverse reactions	154
Oxaliplatin	adverse reactions	154
Nadolol	adverse reactions	153
Nortriptyline	adverse reactions	153
Ketoprofen	adverse reactions	148
Perampanel	adverse reactions	147
Betamethasone	adverse reactions (intra-articular/intralesional/intramuscular label)	136
Tamoxifen	adverse reactions	132
Interferon beta 1b	adverse reactions	131
Terazosin	adverse reactions	125
Phenelzine	adverse reactions	122
Vigabatrin	adverse reactions	122
Methotrexate	patient leaflet	11,971
Adalimumab	patient leaflet	10,521

Source: FDA drug labels via openFDA, read October 8, 2026; FAERS via openFDA, reports through July 30, 2026

Which of them have the most weight gain reports in FAERS?

Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.

Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026; MedDRA preferred term “Weight Increased”

What next?

Side effects across medicines: every reaction on PlainMeds
Report a side effect to the FDA: MedWatch