Omeprazole and sodium bicarbonate Brand names: Zegerid, Konvomep

What is omeprazole and sodium bicarbonate used for?

From the label: indications and usage

treats frequent heartburn (occurs 2 or more days a week) not intended for immediate relief of heartburn. This drug may take 1 to 4 days for full effect.

Conditions named in the indications of omeprazole and sodium bicarbonate's FDA labels, with every medicine labeled for each:

• Acid reflux and ulcers

From other omeprazole and sodium bicarbonate labels

Acid reflux and ulcers: Use treats frequent heartburn (occurs 2 or more days a week) not intended for immediate relief of heartburn.

FDA pharmacologic class: Osmotic Laxative and Proton Pump Inhibitor.

What does the patient leaflet for omeprazole and sodium bicarbonate say first?

The FDA-approved Medication Guide or Patient Information that comes with the medicine, in its own words.

From the patient leaflet: What is the most important information I should know about Omeprazole and Sodium Bicarbonate capsules?

Omeprazole and Sodium Bicarbonate capsules may help your acid-related symptoms, but you could still have serious stomach problems. Talk with your doctor. Omeprazole and Sodium Bicarbonate capsules can cause serious side effects, including: A type of kidney problem (acute tubulointerstitial nephritis). Some people who take proton pump inhibitor (PPI) medicines, including Omeprazole and Sodium Bicarbonate capsules, may develop a kidney problem called acute tubulointerstitial nephritis that can happen at any time during treatment with Omeprazole and Sodium Bicarbonate capsules. Call your doctor right away if you have a decrease in the amount that you urinate or if you have blood in your urine. Omeprazole and Sodium Bicarbonate capsules contains sodium bicarbonate. Long-term use of bicarbonate with calcium or milk can cause a condition called “milk-alkali syndrome”. Long-term use of sodium bicarbonate can cause a condition called “systemic alkalosis”. Talk to your doctor about any questions you may have. Too much sodium can cause swelling and weight gain. Tell your doctor if you are on a low-sodium diet or if you have Bartter’s Syndrome (a rare kidney disorder). Tell your doctor right away if you have confusion, shaking hands, dizziness, muscle twitching, nausea, vomiting, and numbness or tingling in the face, arms, or legs. Diarrhea caused by an infection (Clostridium difficile) in your intestines. Call your doctor right away if you have watery stools or stomach pain that does not go away. You may or may not have a fever. Bone fractures (hip, wrist, or spine). Bone fractures in the hip, wrist or spine may happen in people who take multiple daily doses of PPI medicines and for a long period of time (a year or longer). […]

From the patient leaflet: How should I store Omeprazole and Sodium Bicarbonate capsules?

Omeprazole and Sodium Bicarbonate capsules comes in child resistant package. Store Omeprazole and Sodium Bicarbonate capsules at room temperature between 68°F to 77°F (20°C to 25°C). Keep Omeprazole and Sodium Bicarbonate capsules in a tightly closed container. Keep Omeprazole and Sodium Bicarbonate capsules in a dry place and out of light. Keep Omeprazole and Sodium Bicarbonate capsules and all medicines out of reach of children.

Is there a generic for omeprazole and sodium bicarbonate (Zegerid)?

The FDA approved the first generic omeprazole and sodium bicarbonate on May 25, 2010. 16 generic applications are approved; 13 of them carry a current (not discontinued) marketing status in Drugs@FDA; that status is not evidence that the generic is on sale.

FDA's NDC Directory lists omeprazole and sodium bicarbonate from 20 labelers under a generic (ANDA) application and from 3 brand labelers. A listing means the company has registered the product for sale; it does not show that every pharmacy stocks it.

The Orange Book lists no patent for Zegerid Otc capsules; a patent listed only for Konvomep for oral suspension runs to March 1, 2040. A patent or exclusivity date is not the date a generic goes on sale: court cases and settlements move it either way.

What do pharmacies pay for omeprazole and sodium bicarbonate (Zegerid)?

In CMS's NADAC survey of October 7, 2026, pharmacies paid $7.90 per packet (Omeprazole-bicarb 40-1,680 packet), down 22% from $10.15 on October 8, 2025. The chart's scale runs from the lowest to the highest price shown, not from zero. NADAC is what retail pharmacies paid their wholesalers, per unit, in CMS's monthly survey; what a patient pays depends on insurance and the pharmacy.

Has omeprazole and sodium bicarbonate been recalled?

The FDA's Enforcement Report lists 5 recalls naming omeprazole and sodium bicarbonate since 2013: 0 Class I (the most serious), 5 Class II, 0 Class III; 0 still ongoing. A recall names products and lots, not every product of the medicine.

What does the omeprazole and sodium bicarbonate label say about other medicines?

The omeprazole and sodium bicarbonate label names 24 other medicines in its interaction, contraindication or warning sections. The sentences are the labels' own; a label lists what its studies and reports found, not every interaction.

Every other medicine the omeprazole and sodium bicarbonate label names

Check omeprazole and sodium bicarbonate against other medicines

What do FAERS reports show for omeprazole and sodium bicarbonate?

The FDA Adverse Event Reporting System holds 342,964 reports that list omeprazole and sodium bicarbonate among the medicines taken, through July 30, 2026, each a report of something that happened, not proof the medicine caused it; 31,161 are coded as a death and 125,920 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.

Reports received each year

• 23,452
• 22,089
• 28,383
• 31,790
• 25,587
• 22,244
• 21,166
• 20,071
• 19,397
• 19,733
• 9,531

• 2016
• 2017
• 2018
• 2019
• 2020
• 2021
• 2022
• 2023
• 2024
• 2025
• 2026

The most reported reactions

• Fatigue20,662
• Nausea (named in the label)20,591
• Diarrhoea (named in the label)20,382
• Dyspnoea16,952
• Drug Ineffective (a use or a product term, not a reaction)16,217
• Headache (named in the label)15,271
• Pain14,269
• Vomiting (named in the label)13,763

What else is labeled for the same conditions as omeprazole and sodium bicarbonate?

19 other medicines are given the same way (oral) and in the same FDA class as omeprazole and sodium bicarbonate or labeled mainly for the same use (acid reflux and ulcers), the same class first. Acid reflux and ulcers lists all 27 medicines labeled for it, by any route. The first 8 are below. They are listed as records, not as substitutes: whether one can replace another is a prescriber's decision.

Every medicine labeled for the same conditions as omeprazole and sodium bicarbonate

What next?

Alternatives to omeprazole and sodium bicarbonate

19 medicines for the same use

Other osmotic laxatives

the pharmacologic class, with prices and generics

Omeprazole and sodium bicarbonate side effects

the label's list beside FAERS reports

Check an interaction

what two or more labels say about each other