PlainMeds research, FDA and CMS files of October 8, 2026
The medicines with the most FAERS reports
Adalimumab has the most FAERS reports of any medicine on this site (712,308 through 2026-07-30); the 100 most reported account for 21,863,248 reports.
What the data shows
| Medicine | Reports | Coded death | Coded hospital stay |
|---|---|---|---|
| Adalimumab | 712,308 | 30,985 | 151,145 |
| Etanercept | 595,129 | 17,154 | 66,514 |
| Aspirin | 534,208 | 48,992 | 208,873 |
| Prednisone | 499,950 | 52,155 | 172,763 |
| Methotrexate | 489,791 | 37,720 | 133,303 |
| Dupilumab | 478,975 | 2,193 | 22,558 |
| Omeprazole | 446,179 | 39,203 | 150,196 |
| Acetaminophen | 445,075 | 62,472 | 158,989 |
| Lenalidomide | 420,082 | 53,763 | 109,169 |
| Metformin | 410,076 | 33,853 | 144,551 |
| Amlodipine | 409,186 | 42,260 | 159,402 |
| Furosemide | 398,354 | 61,850 | 195,229 |
| Ergocalciferol | 382,573 | 22,811 | 102,586 |
| Gabapentin | 362,654 | 34,219 | 106,727 |
| Metoprolol | 353,609 | 38,371 | 136,050 |
| Omeprazole and sodium bicarbonate | 342,964 | 31,161 | 125,920 |
| Pantoprazole | 330,183 | 36,440 | 139,578 |
| Oxycodone | 311,625 | 74,855 | 71,489 |
| Lisinopril | 304,309 | 25,263 | 97,537 |
| Dexamethasone | 304,163 | 49,353 | 117,148 |
| Levothyroxine | 300,456 | 19,275 | 85,074 |
| Albuterol | 292,136 | 18,583 | 84,002 |
| Pregabalin | 270,624 | 22,084 | 77,266 |
| Ibuprofen | 270,516 | 18,314 | 84,360 |
| Simvastatin | 248,728 | 22,213 | 95,730 |
| Folic acid | 247,883 | 23,149 | 89,888 |
| Atorvastatin | 245,894 | 18,672 | 70,054 |
| Insulin glargine | 245,619 | 13,523 | 64,727 |
| Infliximab | 243,740 | 14,395 | 70,690 |
| Esomeprazole | 235,202 | 19,686 | 73,131 |
| Ranitidine | 230,803 | 17,888 | 29,264 |
| Rituximab | 219,890 | 37,918 | 70,125 |
| Sertraline | 218,311 | 18,962 | 68,336 |
| Clopidogrel | 211,001 | 23,381 | 97,375 |
| Rivaroxaban | 206,938 | 27,139 | 103,514 |
| Alprazolam | 204,916 | 33,446 | 65,648 |
| Denosumab | 201,378 | 25,734 | 31,434 |
| Losartan | 200,566 | 14,810 | 60,827 |
| Levonorgestrel | 200,218 | 268 | 10,843 |
| Interferon beta 1a | 192,061 | 9,782 | 61,393 |
| Quetiapine | 191,480 | 28,195 | 70,149 |
| Prednisolone | 191,407 | 29,606 | 84,722 |
| Tofacitinib | 186,746 | 9,652 | 26,629 |
| Adapalene | 181,062 | 33 | 359 |
| Natalizumab | 180,844 | 5,103 | 34,611 |
| Lorazepam | 178,731 | 25,768 | 74,535 |
| Lansoprazole | 177,061 | 19,914 | 64,598 |
| Cyclophosphamide | 176,005 | 35,641 | 63,677 |
| Montelukast | 174,997 | 7,487 | 47,569 |
| Cetirizine | 171,713 | 11,154 | 39,923 |
| Methylprednisolone | 170,232 | 27,470 | 70,067 |
| Diphenhydramine | 164,832 | 22,785 | 47,567 |
| Evolocumab | 161,222 | 2,035 | 8,504 |
| Tirzepatide | 160,663 | 889 | 10,233 |
| Secukinumab | 160,421 | 8,611 | 21,920 |
| Clonazepam | 159,283 | 18,605 | 47,308 |
| Diclofenac | 158,675 | 13,957 | 43,208 |
| Tacrolimus | 156,020 | 25,784 | 62,864 |
| Allopurinol | 155,998 | 21,961 | 76,437 |
| Hydroxychloroquine | 151,392 | 11,802 | 39,120 |
The table shows the first 60 of 100 rows.
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, read October 8, 2026
How it was measured
openFDA drug/event: reports that list one of the medicine's FDA generic names among the drugs taken (suspect or concomitant), counted per medicine.
What it cannot show
A report does not show the medicine caused anything; counts follow how widely a medicine is used and how closely it is watched. A report can name several medicines and count for each.